PFS possible reason.

[Blugrass]

Maybe that's why TEI is giving me so much copper, I have high aluminum. Who knows

 

[shivgeorge]

Protective effects of copper against aluminum toxicity on acetylcholinesterase and catecholamine contents of different regions of rat’s brain


there is so much confusing info on this topic.

ALS is caused by aluminum and treated with L serine.

L serine increases acetylcholinsterase

Wow! That's incredible. Thanks for the clarification. That pretty much goes contrary to all the other studies I have read where AchE activity is induced by aluminium.

Activation of acetylcholinesterase by aluminium(III): the relevance of the metal species. - PubMed - NCBI

Effect of long-term exposure to aluminum on the acetylcholinesterase activity in the central nervous system and erythrocytes. - PubMed - NCBI

In vivo and in vitro effects of aluminum on the activity of mouse brain acetylcholinesterase. - PubMed - NCBI

But just to confirm, while doing the reading for the above articles, I also came across two other studies that quoted the opposite. Lol.

Cholinergic System Under Aluminium Toxicity in Rat Brain

Effect of long-term exposure to aluminum on the acetylcholinesterase activity in the central nervous system and erythrocytes. - PubMed - NCBI

 

[Helen]

Wow! That's incredible. Thanks for the clarification. That pretty much goes contrary to all the other studies I have read where AchE activity is induced by aluminium.

Activation of acetylcholinesterase by aluminium(III): the relevance of the metal species. - PubMed - NCBI

Effect of long-term exposure to aluminum on the acetylcholinesterase activity in the central nervous system and erythrocytes. - PubMed - NCBI

In vivo and in vitro effects of aluminum on the activity of mouse brain acetylcholinesterase. - PubMed - NCBI

But just to confirm, while doing the reading for the above articles, I also came across two other studies that quoted the opposite. Lol.

Cholinergic System Under Aluminium Toxicity in Rat Brain

Effect of long-term exposure to aluminum on the acetylcholinesterase activity in the central nervous system and erythrocytes. - PubMed - NCBI

Yes, I agree i read all those studies also, it is very confusing , one says increases and another decreases.


I read that serine get oxidized , and this causes lower acetylcholine activity. Protein levels could be high but may be it is not working


usually neurotransmitters are controlled by amino acids involved in breakdown of neurotrasmitter

Like you give acetylcholine,. the levels go up, now to break it down, you need serine, tryptophan, tyrosine in acetylcholinsterase

So serotonin, dopamine go down.


I wish I could test for sure what aluminum does.


Acetylcholine by raising cortisol usually lowers testosterone.


But cortisol could lower acetycholine release. If cortisol levels are high for some reason.