POTENTIAL explanation for PFS.

[sanka]

Astaxanthin cant help us @Helen ? I read that is 50 times more potent than vitamin E

 

[BeLikeWater]

Regarding the immune system; how come most PFS sufferers don't get sick? I haven't got the flu in years.

I havent had flue also in years, 7 years to be exact, I suspect is high parasympatic dominance, with very low cortisol, look at article I recently post on Tubzy Blog lately.

 

[brix]

I havent had flue also in years, 7 years to be exact, I suspect is high parasympatic dominance, with very low cortisol, look at article I recently post on Tubzy Blog lately.

A lot of people including myself started getting flues and other sicknesses last year after starting to fix their PFS by using ella and RU. I got the flu like 4x last winter.

 

[talkingant]

Thinking about how to increase UGT activity, particularly UGT2B15 and 2B17, as those metabolize androgens most heavily.

• UGT enzymes use UDP-glucuronic acid to attach it's glucuronic acid to another compound, like an androgen
  • UDP-glucuronic acid is made by enzyme UDP-glucose 6-dehydrogenase from UDP-glucose and NAD+
    • How to boost NAD+
    • UDP-glucose is synthesized from glucose 1-phosphate and uridine triphosphate (UTP) in a reaction catalyzed by UDP-glucose pyrophosphorylase
      • Glucose 1-phosphate is made with glucose and ATP
        • L-cartinine increases glucose uptake
        • Some CoQ10 supplements were tested to increase ATP synthesis. Here is one but it's expensive.

So here is my guess at a protocol to increase UGT enzyme activity, by providing substrates:

• Sufficient carbs in diet for glucose
• L-cartinine for glucose uptake
• NADH and CoQ10 for ATP
• Uridine for UDP-glucose
• Nicotinamide Riboside for NAD+

Also, avoid this for more UGT activity:
Green and white teas suppress UDP-glucuronosyltransferase UGT2B17 mediated testosterone glucuronidation

 

[bruschi11]

Thinking about how to increase UGT activity, particularly UGT2B15 and 2B17, as those metabolize androgens most heavily.

• UGT enzymes use UDP-glucuronic acid to attach it's glucuronic acid to another compound, like an androgen
  • UDP-glucuronic acid is made by enzyme UDP-glucose 6-dehydrogenase from UDP-glucose and NAD+
    • How to boost NAD+
    • UDP-glucose is synthesized from glucose 1-phosphate and uridine triphosphate (UTP) in a reaction catalyzed by UDP-glucose pyrophosphorylase
      • Glucose 1-phosphate is made with glucose and ATP
        • L-cartinine increases glucose uptake
        • Some CoQ10 supplements weretested to increase ATP synthesis. Here is one but it's expensive.

So here is my guess at a protocol to increase UGT enzyme activity, by providing substrates:

• Sufficient carbs in diet for glucose
• L-cartinine for glucose uptake
• NADH and CoQ10 for ATP
• Uridine for UDP-glucose
• Nicotinamide Riboside for NAD+

Also, avoid this for more UGT activity:
Green and white teas suppress UDP-glucuronosyltransferase UGT2B17 mediated testosterone glucuronidation

I was using an injectible form of L-carnitine during a time period I was doing well- Sept/Oct 2017. I’d love to supp with powder or capsule form but I’ve heard you need to load up on it to have major effects.

 

[Gumbo]

Jeepers, it’s all TEI now! Am I the only one here doing ARL?

I didn't get the memo either, just finished 2 months worth a few weeks ago. Worked well though. Might give TEI a shot next time to see how they compare.

 

[tallglass13]

I've always know that Carnitine increases fatty acid oxidation. that is why the sports enhancing drug Mildronate, block or inhibits carnitine.

 

[BeLikeWater]

A lot of people including myself started getting flues and other sicknesses last year after starting to fix their PFS by using ella and RU. I got the flu like 4x last winter.

I have taken Ella, it helped me after my progesterone cycles that I felt femenin for no reason, I look at males different no homo just femenin was nightmare, it corrected that fortunatly. Also give me a very nice booze from 2 beers after it, it was like drink beer for the first timw, it disnt stayed lile that.

 

[BeLikeWater]

Following above post who took only Ella and have started having flue again? Can you direct me to him? Thank you

 

[RebelWithACause]

Yes also got the flu after Ella but after that not anymore

 

[RebelWithACause]

Thinking about how to increase UGT activity, particularly UGT2B15 and 2B17, as those metabolize androgens most heavily.

• UGT enzymes use UDP-glucuronic acid to attach it's glucuronic acid to another compound, like an androgen
  • UDP-glucuronic acid is made by enzyme UDP-glucose 6-dehydrogenase from UDP-glucose and NAD+
    • How to boost NAD+
    • UDP-glucose is synthesized from glucose 1-phosphate and uridine triphosphate (UTP) in a reaction catalyzed by UDP-glucose pyrophosphorylase
      • Glucose 1-phosphate is made with glucose and ATP
        • L-cartinine increases glucose uptake
        • Some CoQ10 supplements weretested to increase ATP synthesis. Here is one but it's expensive.

So here is my guess at a protocol to increase UGT enzyme activity, by providing substrates:

• Sufficient carbs in diet for glucose
• L-cartinine for glucose uptake
• NADH and CoQ10 for ATP
• Uridine for UDP-glucose
• Nicotinamide Riboside for NAD+

Also, avoid this for more UGT activity:
Green and white teas suppress UDP-glucuronosyltransferase UGT2B17 mediated testosterone glucuronidation

Creatine can increase ATP synthesis I think.

 

[bruschi11]

Creatine can increase ATP synthesis I think.

Yup... How Creatine Improves ATP Synthesis for Both Brain and Body .

I use an electrolyte drink from seeking health that actually has creatine in it. Shawn Bean loves it.

 

[hairsuit]

Yup... How Creatine Improves ATP Synthesis for Both Brain and Body .

I use an electrolyte drink from seeking health that actually has creatine in it. Shawn Bean loves it.

I took creative several months ago, trying to see if it had a benefit with the PFS. Never felt worse. Pre PFS I took it all the time, no issues. Much different this time around.

 

[RebelWithACause]

I took creative several months ago, trying to see if it had a benefit with the PFS. Never felt worse. Pre PFS I took it all the time, no issues. Much different this time around.

@hairsuit

What negative effects die you notice on creatine.

I have used creatine for 2 months or so did not feel great on it. Not like I used to. Creatine used to give me great mood + confidence. Worked really well as an antidepressant and muscle gains. My face also looked fuller/healthier on creatine back then.

Creatine raises 5AR activity which means creatine lowers metabolism (indirectly)? Just like l-carnitine.

For me when I use it I get more nervous and unable to rest. Probably rise in aldosterone. Maybe for someone with low NA it could help them. Not sure. Or it is just PFS problem that causes creatine not to have same effect.

I might try creatine low dose in the future again after I have done TEI cycles.

 

[Niles]

Astaxanthin cant help us @Helen ? I read that is 50 times more potent than vitamin E

It is also a 5-AR inhibitor:
A preliminary investigation of the enzymatic inhibition of 5alpha-reduction and growth of prostatic carcinoma cell line LNCap-FGC by natural astaxa... - PubMed - NCBI

It seems like most things listed on this page that increase glucuronidation are also 5-ARIs - @Helen is there a particular reason for this?

 

[sanka]

Which one else?

 

[Helen]

@sanka are you still taking electrolytes protocoL?

 

[sanka]

Yes. Im taking b 2 instead of b1 now, i think im feeling better, with b1 i feel very tired. Now with the protocol with just 100 mg of b1( this frim the b 100 complex) and 1 gr b2. I dont know maybe i try later raising the dose again

 

[Helen]

Yes. Im taking b 2 instead of b1 now, i think im feeling better, with b1 i feel very tired. Now with the protocol with just 100 mg of b1( this frim the b 100 complex) and 1 gr b2. I dont know maybe i try later raising the dose again

Yeah, good job. Orion is also doing higher b2 than b1 with all other ingridients.

 

[sanka]

Yes, i remember to saw one of your post saying that high dose b1 you will feel like shit and some people will feel better with b2. I will continue like this and im planning a liver flush.