PSSD and beta-1 adrenergic receptor

[Helen]

https://www.onlinelibrary.wiley.com/doi/abs/10.1002/ddr.430030502

A pilot study of the pharmacodynamic impact of SSRI drug selection and beta-1 receptor genotype (ADRB1) on cardiac vital signs in depressed patient... - PubMed - NCBI


Beta-1 adrenergic receptor - Wikipedia



https://www.sciencedirect.com/science/article/abs/pii/S0197018618301748



Beta -1 receptor is activated mainly by noradrenaline. So this is why imbalance of PSSD is similar as with PFS in some cases.


@talkingant @Jaxx @barbaar

 

[Helen]

Glucocorticoids down-regulate beta 1-adrenergic-receptor expression by suppressing transcription of the receptor gene. Cortisol downregulates Beta-1

 

[barbaar]

Glucocorticoids down-regulate beta 1-adrenergic-receptor expression by suppressing transcription of the receptor gene. Cortisol downregulates Beta-1

These guys say antidepressants also downregulate beta-1 Sci-Hub | Treatment with antidepressants and down regulation of beta-adrenergic receptors. Drug Development Research, 3(5), 393–406 | 10.1002/ddr.430030502

Among these pharmacological actions of antidepressant drugs, down regulation of beta-adrenergic receptors after chronic, but not acute, treatment is of particular interest.

Althought these guys A Pilot Study of the Pharmacodynamic Impact of SSRI Drug Selection and Beta-1 Receptor Genotype (ADRB1) on Cardiac Vital Signs in Depressed Patients: A Novel Pharmacogenetic Approach say SSRI has beta blocking action, which I would assume to upregulate beta-1 receptors.

Maybe the first study is wrong?

Also alpha-1 is involved in sodium reabsorbtion by the kidneys Alpha-1 adrenergic receptor - Wikipedia, maybe that could explain my huge sodium loss?

Also beta-1 upregulation might be involved in post SSRI hypertension I guess

 

[Helen]

@barbaar No , you are losing sodium, since progesterone is HIGH. and it is wasting sodium and retaining potassium. thus potassium is low in the urine, and sodium is high

 

[barbaar]

@barbaar No , you are losing sodium, since progesterone is HIGH. and it is wasting sodium and retaining potassium. thus potassium is low in the urine, and sodium is high

I see. I just saw it in the list on the wiki page and thought it might be worth mentioning.