PSSD Discussions

[fablecloth]

I think PSSD is connected to deficiencies in magnesium and manganese and possible copper.

As I saw on the blood tests, people with PSSD have high aldosterone, and high progesterone. We could try to lower aldo with magnesium and kill 3 beta hsd with manganese.

Hi @gdolduev - for what it's worth, I have PSSD, but I have low progesterone. My testosterone levels are very low.

 

[Canari]

Probably for every issue we will find 2 opposite cases...

 

[Sam90]

I was just doing some searching of old posts in the PSSD Forum and found one guy named gatogordito who saw improvements when supplementing Zinc, magnesium and copper.

When taking zinc picolinate and zinc monomethionine he saw improvements the next day whilst zinc gluconate helped whilst on it. The improvements came and went but I think became more consistent once he added copper. I've posted links to two of the threads he detailed his experience. I don't think he had zinc levels tested which is a shame because I guess its possible he was low or high.

PSSD Collaborative Research • View topic - Zinc
PSSD Collaborative Research • View topic - Copper binds to serotonin

 

[namaste]

@gbolduev I appreciate you looking into this. I'm ready and willing to be a lab rat for some of this stuff, although I need to establish a baseline over the next few months before beginning. I'm currently trying to get my diet, exercise regimen, sleep schedule, and stress levels straight. Perhaps I'll get some mineral and/or blood tests done.

 

[barbaar]

@gbolduev I appreciate you looking into this. I'm ready and willing to be a lab rat for some of this stuff, although I need to establish a baseline over the next few months before beginning. I'm currently trying to get my diet, exercise regimen, sleep schedule, and stress levels straight. Perhaps I'll get some mineral and/or blood tests done.

+1

I have a hair test on the way, still no bloods though.

 

[Jaxx]

Would be great to have some pssd trials going! I am especially curious of the effects on anhedonia.

 

[Ghost]

Has anyone with PSSD actually tried Manganese? I'd be willing to add it eventually probably. I just don't want to add too much to my current stack:

900mg Ashwagandha
5mg Cialis
50mg Zinc
4x Fish Oil
500mg Magnesium
4000 IU Vitamin D
1200mg Lecithin
200mg r-andro

Thoughts, @gbolduev ???

I think this is all masking the decrease I had coming off of Ginkgo, which I was on for like 3 months. Might add it back in again too at some point. I'm feeling a bit of hopelessness atm and am going ALL IN on fixing this. If I see nothing I'll be doing a week long fast in a month or so, and then a 30+ day one this summer. I'm getting better, or I'm dying trying.

 

[Helen]

@Ghost Have you tried Apocynin. I suspect NADPH oxidase is activated too much in PSSD, since there is too much free zinc available.

Do you have high insulin also? just like Shadow?

 

[Ghost]

@Ghost Have you tried Apocynin. I suspect NADPH is activated too much in PSSD, since there is too much free zinc available.

Do you have high insulin also? just like Shadow?

I haven't gotten my insulin tested before. I agree with the NADPH possibility. I know of a PSSD-er (Brooks Witzke) who researched NADPH Oxidase and discovered that the use of Apocynin cured his PSSD for a few days at a time, but after a while it stopped working the same. Seems to him and I that NADPH is secondary to increased Serotonin, and eventually NAPDH oxidase must up-regulate to fight the Apocynin. I'll see if I can get him on here to share his work and experience from the past few months - he collected quite a bit and I think people would learn a lot from it.

 

[Helen]

I haven't gotten my insulin tested before. I agree with the NADPH possibility. I know of a PSSD-er who was cured on Apocynin, but after a while it stopped working. Seems to me to be secondary to increased Serotonin, and eventually NAPDH oxidase must up-regulate to fight the Apocynin.

Good, I just wanted to see the reaction to apocynin, I am not suggesting it as a cure, it cant be a cure. I am taking on one person with PSSD this week into my skype. And I will try to fix him and then I will post how I did it.

 

[Ghost]

Good, I just wanted to see the reaction to apocynin, I am not suggesting it as a cure, it cant be a cure. I am taking on one person with PSSD this week into my skype. And I will try to fix him and then I will post how I did it.

Awesome, man! Will be interesting to see how it works.

Do you think that SSRIs could induce some form of Diabetes or insulin problems? Is this something that I might want to get a test done for?

 

[Helen]

Awesome, man! Will be interesting to see how it works.

Do you think that SSRIs could induce some form of Diabetes or insulin problems? Is this something that I might want to get a test done for?

yes if you could also help me and get some tests done it would be nice. i need insulin , and electrolytes.

Do you have any blood tests for people with PSSD I can look at . Did people test insulin on your forum?

 

[Ghost]

yes if you could also help me and get some tests done it would be nice. i need insulin , and electrolytes.

Do you have any blood tests for people with PSSD I can look at . Did people test insulin on your forum?

I think Insulin would be pretty easy, but where do I get the electrolytes? Yea PM me (My PM doesn't let me start convos), and I'll send them to you.

 

[Shadow]

My insulin was high even before PSSD(during ssri usage), my diet is terrible, so I dont know if in my case it has something to do.

@Ghost its been some time since I talked with Brooks, hes still researching?

 

[Ghost]

My insulin was high even before PSSD(during ssri usage), my diet is terrible, so I dont know if in my case it has something to do.

@Ghost its been some time since I talked with Brooks, hes still researching?

Yea, he still is. I'm hoping that he'll get on here soon and share some of his stuff.

 

[Crushed]

yes if you could also help me and get some tests done it would be nice. i need insulin , and electrolytes.

Do you have any blood tests for people with PSSD I can look at . Did people test insulin on your forum?

I am willing to get any test needed as well.

 

[Shadow]

@Ghost I was thinking about the hypothesis of us being stuck in SSRI state, them I remebered that some sufferers used MAOIs, correct me if Im wrong, but if we are in ssri state, a MAOI shoundt make us sick leading to a possible serotonin syndrome, or at the best, make our symptoms worse?

 

[Helen]

@Ghost I was thinking about the hypothesis of us being stuck in SSRI state, them I remebered that some sufferers used MAOIs, correct me if Im wrong, but if we are in ssri state, a MAOI shoundt make us sick leading to a possible serotonin syndrome, or at the best, make our symptoms worse?

NO. since metabolism went even lower, and body lowered serotonin even more than before, so MAOI inhibitor will be like going on low dose SRRI. which will make you feel better with your brain , but worse with metabolism.


Serotonin needs potassium copper and chloride. otherwise it will cause harm. Gaba A receptor will use up chloride. Serotonin will use up copper, and potassium is needed to even secrete it. since serotonin should be secreted in fast metabolism. ACTH goes up only if potassium is high in the cell. in low potassium medium cortisol should be kept low.

 

[raskolnikov]

There's a lab results topic at PSSD Forum. Numbers are quite different between one and other person, but low FSH and low LH are almost aways there. I do have very low testosterone (9 nmol/L). I thought testosterone would be the answer, but other people there have double or triple my T levels and still feel all the PSSD symptoms.

Anyway, as long as we dont have a protocol for cure, what would you recommend me to take/do in order to raise my testosterone levels naturally, @gbolduev ? Is aswagandha a good try? My focus is on testosterone now. I'm going 5x/week to the gym, but it's not enough to raise testosterone to decent levels for my age (I'm 27)

 

[Miguel29]

In a very similar situation as raskolnikov (low t after ssri).

I've spoken to dozens of doctors now about pssd. Only two of them have said that ssri's do decrease testosterone, lh, fsh, etc... Neither one of them had any suggestions of how it is causes or if it will be permanent (altered hormonal homeostasis).

The only treatments offered have been trt and clomid, neither is a cure, only management of a condition.

It would be interesting to hear from @gbolduev or anyone else whether they believe low-t after ssri is permanent.