PSSD explanation( high ZINC)

[Helen]

PSSD is possible zinc toxicity( or copper in some cases may be more for PFS)


mechanism goes like this.

and in this case, ZINC increases GABA B.

that is ALL.


zinc blocks gaba a , this increases glutamate to gaba conversion. so total GABA level goes up.

this total GABA level acts on GABA B receptor. GABA B thru inositol phos phate increases intracelluar CALCIUM


progesterone goes up, cortisol is inhibited. histamine inhibited, estrogen inhibited,( low cannabinoids, low anandamide) low opiods - these are your emotions.

this is PSSD.



SSRIs put zinc into the brain. and most people needed magnesium not zinc.


SSRI acts on CRF , CRF increases ACTH, ACTH puts ZINC into the cell. This is the mechanism of SSRI.


when calcium is high in the cell. metabolism is SLOW, progesterone goes up, and CORTISOL stays down. and that is CORRECT


Cortisol and Estrogen go up in fast metabolism. estorgen increases anandamide which gives you emotions, estrogen increases histamine, which gives you libido.

and estrogen increases acetycholine. which gives you sensitivity.


@talkingant @Jaxx @barbaar @Area-1255 @Astral kid

 

[Nina]

"zinc blocks gaba a , this increases glutamate to gaba conversion. so total GABA level goes up."

If it blocks Gaba-a, then how would it increase total Gaba levels?

 

[Helen]

"zinc blocks gaba a , this increases glutamate to gaba conversion. so total GABA level goes up."

If it blocks Gaba-a, then how would it increase total Gaba levels?

what ? it blocks GABA A receptor, and increases production of GABA> by converting glutamate to gaba. So now you have gaba A receptor |BLOCKED

and levels of GABA high. this high level acts on GABA B receptor. increasing intracellular calcium by inositol triphosphate

 

[Helen]

@Ingeno some people get PSSD and PFS type of symptoms after taking zinc. it is not a joke. and not a candy.

 

[Helen]

Copper actually could act similar, since it also blocks gaba A

 

[Ingeno]

@Ingeno some people get PSSD and PFS type of symptoms after taking zinc. it is not a joke. and not a candy.

I understand that now. Also in my teens at first I felt great on zinc, greater libido and more power in the gym. Now on TEI I feed bad on zinc, no libido at all and a lot of apathy.

 

[Helen]

Activation of mTOR dependent signaling pathway is a necessary mechanism of antidepressant-like activity of zinc. - PubMed - NCBI
GABA B receptors increase intracellular calcium concentrations in chromaffin cells through two different pathways: Their role in catecholamine secretion, Journal of Neuroscience Research | DeepDyve

 

[Ergogenic Health]

@Ingeno some people get PSSD and PFS type of symptoms after taking zinc. it is not a joke. and not a candy.

ME!

I can't tolerate Zinc. Makes me feel horrible. 3 years ago, this was never an issue (ZMA Every night).

 

[Ergogenic Health]

Why is there no talk of HOMOTAURINE gor GABA-B actvity.

 

[Nina]

ME!

I can't tolerate Zinc. Makes me feel horrible. 3 years ago, this was never an issue (ZMA Every night).

Me aswell, horrible on zinc. Took 100-150mg daily for over a year which completely fucked me up. Lost emotions, felt apathetic 24/7 like a zombie. Also it made me pale AF

 

[Ergogenic Health]

Me aswell, horrible on zinc. Took 100-150mg daily for over a year which completely fucked me up. Lost emotions, felt apathetic 24/7 like a zombie. Also it made me pale AF

So terrible. Zinc is so toxic at high doses. We should really be careful.

How do you feel on Olive Leaf extract?

Also - We struggle with low sodium symptoms... since Licorice helps us.