RU / "Mifepristone Challenge" Log
- Thread starter jinstewart
- Start date
jinstewart
Well-Known Member
- Messages
- 189
Hmmm, maybe that's the emotional/regret feeling that creeps in. And/or the lethargy bit I'm doing. Thanks for the heads-up, braced for it...
(EDIT - can I ask a question, if you promise not to tell the others? ...Is masturbation likely to set me back any at this point or shall I got for it? I suppose I should be a good 'control' and leave it for a week or two.)
Last edited:
- Messages
- 2,795
It shouldn’t kill you just watch yourself. 3-4 times a week should be fine. I ejaculate daily for the most part.
But prolactin is spiking for you currently and ejaculation increases it further so just watch your body.
RebelWithACause
Well-Known Member
- Messages
- 2,613
Stop masturbating god damn it lol you fucking addicts
- Messages
- 2,795
I get laid lol. My pfs is doing well. Just bad gut/cfs issues.
- Messages
- 2,590
The emotions type feeling is from blocking cortisol in my experience. When cortisol is blocked it turns my emotions back on since my body isn't stuck in a constant stress type state. The regret type feeling allows you to think more clear and turn the stress off, I know the type of feeling you are referring to. Its likes a regret type feeling like damn I wasted so years in this fucked up PFS state, but you don't necessarily feel depressed about it quite the opposite actually. I get that a lot when I turn cortisol off and my brain thinks clearly again. But this comes back to just turning your emotions back on and you start realizing shit again. PFS state you feel zero emotion towards anything.
Last edited:
- Messages
- 2,795
When you block cortisol, you block serotonin. And vice versa. So RU and cyproheptadine aren’t so different.
Problem is- serotonin is like candy to the brain in terms of depression when you get it right. Like if you’re low cortisol for a long time like me in early to mid 2010s- and then you suddenly elevate it and make it right? You’re going to be happiest guy in world.
A lot of people just get used to living with low cortisol or suffer with psychiatric issues. Girl I dated last year worked in research at McCleans’s Hospital- deemed one of best mental hospitals in world. Lol that’s where I was when I was really really bad.
Anyways, she said in regards to research- “Almost ALLLLLLL of these people have low saliva cortisol. It’s really automatic each of these tests.”
So this is why you feel depressed @jinstewart . I wouldn’t say it’s more a feeling of normality and regret @Boris . Trust me lol when I turn cortisol too far down it happens every time. Sure the feelings happen to you, but I think it’s more about the low cort environment which turns off the ability to be happy in the brain.
- Messages
- 2,590
Cypro and RU are not the same feeling at all nor do they act similar. I tried both cypro I feel really weird on and brain fog. It does way more than block sertonin, but is a strong anti histamine and anti acetylcholine.
Cyproheptadine - Liquid Serotonin Antagonist For Lab/R&D
RU does nothing to that effect to my knowledge and in my experience none of any of Ray Peat's or Haidut's anti serotonin did anything that RU did. Anything that lowers cortisol I feel insanely weird and horrible with brain fog.
RU blocks the GR it doesn't just lower cortisol like many of the supplements that block serotonin (cypro for example). Blocking the GR is different from just lowering cortisol, when you block GR cortisol rises since it can't bind. Cypro does the opposite of that it lowers cortisol instead of blocking the GR. I have taken many "anti serotonin" supplements from the peaters and they did nothing in terms of the same effect of RU.
Cyproheptadine Lowers Cortisol, Endorphins, HGH, Aldosterone
Anavar also blocks GR (no clarity on if it crosses BBB well) but it has no effect on progesterone or the prog receptor...so in theory it seems to fill in for fin as a stilt
- Messages
- 5,415
- Messages
- 2,795
They don’t feel the same at all. But they both block serotonin/ cortisol potently. I get depressed on both. Different feelings of depression but depression nonetheless.
Will say RU is far more feelings of normality with the added libido. Cyproheptadine just wipes out libido, any drive at all to do anything. I took it a couple months ago for a day lol I didn’t want to move!
Last edited:
- Messages
- 2,590
I'm just going off by what you said for var, see below
https://hackstasis.com/threads/role-of-glucocorticoid-receptors.1128/#post-31363
- Messages
- 2,590
I don't get that experience on RU but didn't you take caber or other anti prolcatin supps stuff while on RU? Maybe could have altered it a bit possibly or maybe a different case. Also did you measure your prolactin while on RU? How do you know it was high. As we now know the original doses of RU we were taking were miniscule
Last edited:
Lol, don't mess with the test.. all that prep for a few sec of pleasure.. ? Discipline!
- Messages
- 2,795
Dick/erections absolutely died on RU like day 3, 4 and immediately upon adding dopamine agonist after (metergoline first cycle, L-Dopa 2nd) dick would be fine. Libido remained all along.
No testing. We had someone post some bloods here maybe a week after testing. His hormones were like crazily all over the place like HUGE changes. Including the elevated prolactin I believe.
- Messages
- 2,590
You are talking about Willy Long, he did not test prolactin - only estrogen (E2). Plus he was on big doses of test while taking RU
https://hackstasis.com/threads/got-estrogen-bloodwork-while-on-ru486.651/
Also, RU is anti androgenic, it blocks AR so your loss of libido could be from that.
- Messages
- 2,795
Wasn’t loss of libido. Erections absolutely died. Libido stayed.
Dopamine agonists brought the erections back to above baseline I’d say because of the libido I now had.
I think RU did certainly indeed have big impact on regaining sexual function no doubt in my mind.
- Messages
- 2,590
Those are also sides of anything anti androgenic as well it's not limited to just libido. Have you tried dopamine agonists alone or not while being on RU? Any dopamine agonist can increase libido anything from cocaine, caffeine, prami, bromo etc it's not just for ED issues only. I think we really are not sure if RU does raise prolactin (we have no tests) and if it actually does would taking something to counteract it be beneficial in improving baseline at all? Having a clean trial with tests are a must around here or we will have another @IHateFin lol
jinstewart
Well-Known Member
- Messages
- 189
Morning all - day 5/5 is here. Last dose tonight.
Noticing lethargy, slightly odd stomach feeling, maybe a tiny bit of unusual throat pain once or twice since last night (thyroid?) The "on-cycle" bloods were just taken now, so they'll be with us in a week or so.
I didn't masturbate, I was good. I'll leave that another week.
Slept a little better but might have been exhaustion. I am pretty tired. Hungry but no appetite really either, which is a weird one to try and explain.
Certainly "feeling" a tiny tiny little more like the old me, but it's slightly strange. Anyway, all sides I've had so far have been very tolerable. I didn't make gym last night and won't tonight (annoyingly, I'd wanted to keep that up through the week. Life-issues rather than PFS/RU issues. I'd probably be in there to diminished lifts and energy though.)
Let's hope the snapback or whatever happens after leaves us somewhere good.
Thanks for all the posts and everything. At least we'll learn something or write it off.
EDIT - FINALLY the "Pre Bloods" DHT results have come in and the retards have changed the scale. Amended the OP. Basically, DHT is higher than it was back in March, and on their previous scale would have been mid-high, but is now a bit on the low side on their new scale. Oh well.
Noticing lethargy, slightly odd stomach feeling, maybe a tiny bit of unusual throat pain once or twice since last night (thyroid?) The "on-cycle" bloods were just taken now, so they'll be with us in a week or so.
I didn't masturbate, I was good. I'll leave that another week.
Slept a little better but might have been exhaustion. I am pretty tired. Hungry but no appetite really either, which is a weird one to try and explain.
Certainly "feeling" a tiny tiny little more like the old me, but it's slightly strange. Anyway, all sides I've had so far have been very tolerable. I didn't make gym last night and won't tonight (annoyingly, I'd wanted to keep that up through the week. Life-issues rather than PFS/RU issues. I'd probably be in there to diminished lifts and energy though.)
Let's hope the snapback or whatever happens after leaves us somewhere good.
Thanks for all the posts and everything. At least we'll learn something or write it off.
EDIT - FINALLY the "Pre Bloods" DHT results have come in and the retards have changed the scale. Amended the OP. Basically, DHT is higher than it was back in March, and on their previous scale would have been mid-high, but is now a bit on the low side on their new scale. Oh well.
Last edited:
jinstewart
Well-Known Member
- Messages
- 189
Okay so last dose was last night. Sleep was better (5 hours then >1 hour,) the lethargy grows and grows. Appetite took a bit hit too. Occasional odd throat aches - I want to say thyroid but idk. The 'sour headache' is being kept firmly at bay, and that's a BIG plus for me, but romantic personal life stresses have been huge this week (who'd have thought an impotent finasteride zombie would warrant the tears and screaming?) Wish she could have picked a better week for this...
Aaanyway, personally feel a little more like my old self, but again only a little. Sexually perhaps even a little worse than usual - nocturnals went and morning wood isn't a thing again. Back to the gym later, will update on how that goes. I've been fine to drive throughout, ability to work pretty much unaffected, and in general terms felt mentally better for sure throughout, with a general trend of improvement in quality of life as it went on.
Have been on no other supps of course of any sort for over a week and I'll stay off everything until at least Monday, when my plans are just another Tribulus cycle as per Apr1989. I'll also sit on my hands and not masturbate for another week or so.
Well then - now we wait! See how the snapback is or the come-down is! I might well leave it a couple weeks to take "post-cycle bloods" and that way if anything dramatic happens (or doesn't) it's all had a little time to settle. "On-cycle bloods" should be with us piecemeal, latest next Friday I'd hope.
As always, any comments or advice or discussion or requests totally welcome.
Aaanyway, personally feel a little more like my old self, but again only a little. Sexually perhaps even a little worse than usual - nocturnals went and morning wood isn't a thing again. Back to the gym later, will update on how that goes. I've been fine to drive throughout, ability to work pretty much unaffected, and in general terms felt mentally better for sure throughout, with a general trend of improvement in quality of life as it went on.
Have been on no other supps of course of any sort for over a week and I'll stay off everything until at least Monday, when my plans are just another Tribulus cycle as per Apr1989. I'll also sit on my hands and not masturbate for another week or so.
Well then - now we wait! See how the snapback is or the come-down is! I might well leave it a couple weeks to take "post-cycle bloods" and that way if anything dramatic happens (or doesn't) it's all had a little time to settle. "On-cycle bloods" should be with us piecemeal, latest next Friday I'd hope.
As always, any comments or advice or discussion or requests totally welcome.
- Messages
- 5,415
@Boris You see this guy reacts to RU completely differently. He does not feel recovered on RU.
Since @Boris you had high cortisol and 4 highs, cortisol retains sodium, which stops 5AR
Slow oxidizers usually have low sodium , very low sodium levels. and thus 5AR and DHT usually high. So @bruschi11 and @jinstewart don't feel recovered and actually feel worse erection wise while on RU. Since RU by blocking cortisol , probably lowers their sodium even further. and the body has to convert dopamine into noradrenaline to activate the adregenic receptors more. thus their prolactin goes even higher
In your case @Boris , RU blocks cortisol, sodium retention falls. and this actually causes more 5AR.
hopefully something will happen on the snapback
Since @Boris you had high cortisol and 4 highs, cortisol retains sodium, which stops 5AR
Slow oxidizers usually have low sodium , very low sodium levels. and thus 5AR and DHT usually high. So @bruschi11 and @jinstewart don't feel recovered and actually feel worse erection wise while on RU. Since RU by blocking cortisol , probably lowers their sodium even further. and the body has to convert dopamine into noradrenaline to activate the adregenic receptors more. thus their prolactin goes even higher
In your case @Boris , RU blocks cortisol, sodium retention falls. and this actually causes more 5AR.
hopefully something will happen on the snapback