Similarities between PAS and PSSD

[MNK99]

@Flynn.
-Here's Ghost's PSSD wordpress blog: What’s Been Tried
-Also @Ghost posted this re: PSSD recoveries - Success Stories

 

[tanedout]

OK. I still think people need to try RU at higher doses.

Yeah I agree that sounds like the most promising thing at the moment. The people who've made good gains seem to be the ones who've done a cycle of RU or ella, and they've then been able to build it on it.

I'm currently focusing again on gut health which is clearly a massive issue in all these conditions. Having been getting quite bad chest pain recently, I think it's related to GERD or acid reflux which I have had previously. This ties in with low stomach acid, but I think sometimes for me taking HCL after a meal actually makes it a bit worse, so I'm cutting back for the time being. Looking into what helps people for this, and actually i was a bit surprised to see it's often seen as poor gut health is the root cause, and people have found probiotics and anti-candida protocols help a lot with resolving GERD/acid reflux issues.

So I'm now taking anti-candida sups again which usually contain things like black walnut and oregano oil, and loading up on probiotics. Don't eat any sugar or processed foods, and no/minimal gluten.

Another possible issue I think is oxalates. Unfortunately spinach is very high in oxalates, and the oxalate acid binds to minerals further reducing their availability (reduces calcium and magnesium the most) for a body which is clearly already low, so I'm going to be avoiding things like spinach, loads of tea and nuts etc which are very high in oxalates, and introducing some amino like l-lysine which help with the absorption of calcium.

Re-introducing pine pollen again has been a plus for mental clarity, and this may be down to DHEA content. I'm also re-introducing gingko biloba. These both reduce cortisol so may be partly what they tend to be positives for me;

Phosphatidylserine, DHEA, and ginkgo biloba all have been shown to reduce the amount of cortisol produced during stressful events, and these stress fighters can help retard the negative consequences of this hormone.

Report: Cortisol - page 2 | Life Extension Magazine

 

[Flynn]

Yeah I agree that sounds like the most promising thing at the moment. The people who've made good gains seem to be the ones who've done a cycle of RU or ella, and they've then been able to build it on it.

I'm currently focusing again on gut health which is clearly a massive issue in all these conditions. Having been getting quite bad chest pain recently, I think it's related to GERD or acid reflux which I have had previously. This ties in with low stomach acid, but I think sometimes for me taking HCL after a meal actually makes it a bit worse, so I'm cutting back for the time being. Looking into what helps people for this, and actually i was a bit surprised to see it's often seen as poor gut health is the root cause, and people have found probiotics and anti-candida protocols help a lot with resolving GERD/acid reflux issues.

So I'm now taking anti-candida sups again which usually contain things like black walnut and oregano oil, and loading up on probiotics. Don't eat any sugar or processed foods, and no/minimal gluten.

Another possible issue I think is oxalates. Unfortunately spinach is very high in oxalates, and the oxalate acid binds to minerals further reducing their availability (reduces calcium and magnesium the most) for a body which is clearly already low, so I'm going to be avoiding things like spinach, loads of tea and nuts etc which are very high in oxalates, and introducing some amino like l-lysine which help with the absorption of calcium.

Re-introducing pine pollen again has been a plus for mental clarity, and this may be down to DHEA content. I'm also re-introducing gingko biloba. These both reduce cortisol so may be partly what they tend to be positives for me;



Report: Cortisol - page 2 | Life Extension Magazine

yeah I still think we need to focus on things which directly affect the brain.

 

[Flynn]

Has anyone tried buspirone???

 

[Ghost]

@Ghost I was just wondering man, from your forum which substances have helped reverse PSSD in people? Even if the result couldn't be replicated in everybody else.Are St johns wort? Berberine? or Inositol worth trying?

In response to the earlier question, accutane raised 5ht1a in the 5ht projection areas. I don't think they talked about the RN. You can't really tell from that study if they were presynaptic or postsynaptic receptors. I'd assume postsynaptic. It also increases SERT in some regions, which excited me. There's been disagreement in the community of what's better (agonist/antagonist). @Area-1255 and I have talked about this a lot. I think it depends on if it's pre/post synaptic or not. Also where it works in the brain.

I'd look through the recovery stories on my PSSDlab site. Also there is a section of things we've tried or talked about.

Of those listed, I think Inositol is best, SJW second, Berb third. I've seen recoveries on the first 2.

 

[vicecaz]

@Ghost

By verb you mean berberine ? that's interesting as it surpasses androgen receptor
I've seen recovery with licorice in passed forum too

 

[Flynn]

@Ghost

By verb you mean berberine ? that's interesting as it surpasses androgen receptor
I've seen recovery with licorice in passed forum too

Most things seem to surpass the androgen receptor. Dopamine agonists don't seem to do much. They act beyond the androgen receptor.

I'm very interested in buspirone and maybe even bupropion. If serotonin overactivity is inhibiting dopamine activity. Buspirone may help.

 

[Jaxx]

SJW actually gave alot of PSSD people a clear "w indow" with a feeling of full recovery (including myself). It only lasted a week unfortunately, still not sure what the cause is of this. Recoveries with it are rare though it seems.
Gingko helped me for the anhedonia, not so much for libido. Inositol didnt help me personally, maybe i didnt do it long enough though. If anything it made things slightly worse.
Bupropion didnt help my libido, although it did for others, major insomnia in the first 2 weeks and much energy. Buspirone didnt do that much for me, helped a bit with energy but no negatives either.
Surprisingly Nortrilen (Noradrenalin & minor serotonine activity) increased my libido for 1-2 days, but also caused the numbness you'd expect from a serotonine drug.

 

[IHateFin]

@Ghost I was just wondering man, from your forum which substances have helped reverse PSSD in people? Even if the result couldn't be replicated in everybody else.Are St johns wort? Berberine? or Inositol worth trying?

i think there are a few guys whom have cured their PSSD with just inositol no? i read a few blogs on it. they were at 18g doses a day. i have taken 20g doses a day and it helped my mood a shit ton, but libido wasnt as much of a snap back as those with PSSD. i have PFS so i figured it wouldnt cure me alone, but my mood was hugely upregulated so to speak to a much better baseline. definitely corrected any D2 down reg from D2 agonsit use.

you ever consider LDN for PSSD? read it up-regulates GABA and Dopamine. haven't read anything about serotonin, but i figure that would be indirectly positively affected.

 

[Flynn]

SJW actually gave alot of PSSD people a clear "w indow" with a feeling of full recovery (including myself). It only lasted a week unfortunately, still not sure what the cause is of this. Recoveries with it are rare though it seems.
Gingko helped me for the anhedonia, not so much for libido. Inositol didnt help me personally, maybe i didnt do it long enough though. If anything it made things slightly worse.
Bupropion didnt help my libido, although it did for others, major insomnia in the first 2 weeks and much energy. Buspirone didnt do that much for me, helped a bit with energy but no negatives either.
Surprisingly Nortrilen (Noradrenalin & minor serotonine activity) increased my libido for 1-2 days, but also caused the numbness you'd expect from a serotonine drug.

how long did you take buspirone? It acts on the presynaptic 5HT1A receptor, so I would have thought it would help.

When you say SJW gave you a full recovery, what do you mean? Did you sexual side get completely healed temporarily. I only ask this to get an idea of PSSD. It's interesting to think that dysfunctional serotonin signalling could cause these symptoms.

 

[Flynn]

@Ghost @Jaxx @Area-1255 Have you met many people with PSSD who have tried altering their hormone levels using steroids etc.? This would be very interesting. Something which has always confused me about PAS, is that steroids had no effect on my sexual sides. If this is also true in PSSD, it could be very informative.

 

[Jaxx]

how long did you take buspirone? It acts on the presynaptic 5HT1A receptor, so I would have thought it would help.

When you say SJW gave you a full recovery, what do you mean? Did you sexual side get completely healed temporarily. I only ask this to get an idea of PSSD. It's interesting to think that dysfunctional serotonin signalling could cause these symptoms.

Yes a complete recovery, that lasted a week. More have had this exact same effect, unclear is why.
I took buspirone for about 2 months, effects wore off i felt.

 

[Jaxx]

@Ghost @Jaxx @Area-1255 Have you met many people with PSSD who have tried altering their hormone levels using steroids etc.? This would be very interesting. Something which has always confused me about PAS, is that steroids had no effect on my sexual sides. If this is also true in PSSD, it could be very informative.

There were several members with steroid therapy on the pssd forum, with no success as far as i can recall

 

[Flynn]

There were several members with steroid therapy on the pssd forum, with no success as far as i can recall

OK so you have had complete remission of sexual symptoms? This indicates that there is no permanent damage but that serotonin signalling is dysfunctional in some way.


PSSD and steroids is very interesting. With PAS, steroids have little to no effect. I know accutane can affect dopamine receptor expression. So I assumed steroids had no effect in a way which was related accutanes effect on the dopamine system. However as far as I know SSRI's have no direct impact on dopamine receptor expression. This is interesting as it shows that SSRI's can also make a person resistant to the effects of steroids. Providing more support for a cause of PAS being related to serotonin.