jinstewart
Well-Known Member
- Messages
- 189
Hello all,
Right, made my mind up. Next experiment will be St John's Wort and/or Inositol. Having read a few of the PSSD recoveries here and feeling like laying off the "proper" pharmaceuticals for a while this seems like it'll be worth a stab. My thinking is just fiddling with 5HTA receptors for six weeks or so then stopping, see what it does. I wonder if my chronic use of hayfever medicine (fexofenadine - took 90mg/day for about three years pre-PFS) screwed up these receptors for me, and something to do with that has led to either PFS or aspects of it.
Putting together something vaguely like Beetlebum and PharmD did, it looks to be a toss up between SJW and Inositol. Maybe both can be run together? Alternate weeks even? Idk. Let's find out.
Thinking it could be:
wk1 - SJW 900mg/day
wk2 - SJW 900mg/day (but 4 day break)
wk3 - Inositol 18g/day, Monday single Berberine tablet, Friday 1.5g Choline
wk4 - SJW 1350mg/day
wk5 - Inositol 18g/day, Monday single Berberine tablet, Friday 1.5g Choline
wk6 - SJW 1350mg/day
wk7 - Inositol 18g/day, Monday single Berberine tablet, Friday 1.5g Choline
... [continue until feeling like benefits taper off then stop dead, max 8 weeks.]
Anyone fancy having a think? I'm not sure if I do improve any from cipro (or even fexofenadine) but I know I've had no allergies since the start of the year, and I used to be fiercely allergic to my cat. Would this also go any way to explaining temporary cipro recoveries?
Of course any and all suggestions welcome. Alongside this I'll be running Gillian Hamer's diet and probiotics, the gut protocol, paleo diet and gym 4-5 days/week plus 2x30-60 minute runs/week.
Thinking also of running the following bloods towards the end of the cycle:
DHEA-S
FSH
LH
Test
Free Test
SHBG
FAI
Oestradiol
Prolactin
Albumin
Cheers everybody!
EDIT - I'll try and limit masturbation throughout, have been indulging recently. Have done a LOT of reading on SJW, but not a lot of understanding with it. Wish I had Helen or Boris on speed-dial...
It does look like it increases prolactin, so I'll not do any more to that with excessive masturbation. In my SMALL/probably wrong understanding it works by a different mechanism to upregulate 5HT-x receptors by blocking seratonin recycling and also levels out GABA. I'd imagine some feeling like Beta Blockers? I never took them, but a friend described them as "feeling like always being at 30% and you never move"
I mean, there's more research on SJW than I could read in a year I think, but that's my summary. Have a little dump:
5HT2A Receptors: Anxiety, Fatigue, Sleep Problems & CIRS - SelfHacked
5-HT1A Receptor: The "Single" & "Self-Transcendent" Receptor - SelfHacked
5-HT2C Explains Anxiety, Depression, Weight Gain & More - SelfHacked
Beta-2 adrenergic receptor - Wikipedia
I'm *thinking* SJW primarily affects 5HT2C and Beta-Andrenergic receptors. I'm totally not done researching what Inositol is supposed to do, best I have is "similar but more to do with signalling between things" so I'm not yet sure if alternate weeks is best, if just running SJW 6 weeks then trying inosotol 6 weeks after (or vice versa) might do, but I gotta start somewhere I suppose.
Sod it, I'm feeling brave, I'll prod @Helen and @Boris for an ask.
Recoveries (PSSD) I'm looking at are:
kramdrol (St. John’s Wort)
Beetlebum (St. John’s Wort)
PSSD (Inositol)
PharmD (Inositol)
Hopefully this is worth a gander. SJW and those two types of receptors seem to touch and account for SO much. I'm also so so suspicious my chronic use of fexofenadine over a few years has screwed with this a bit, but there have been recoveries with Trazodone (or at least one) which I think does similar to SSRIs at high doses, and antihistamines at lower ones.
Oh god if only I had one of you guys' brains for a day seriously...
EDIT - Pre-bloods are here for reference:
### Pre-SJW/Inositol bloods ###
Test - 25 nmol/L (8.64-29) high range
Cortisol - 525 nmol/L (166-507) over range
Test/Cort ratio 0.05
Albumin - 45.2g/L (35-50) ok ish
SHBG - 57.4 nmol/L (18.3-54.1) over range
FSH - 4.85 IU/L (1.5-12.4) low-mid
LH - 5.16 IU/L (1.7-8.6) perfectly mid-range
Oestradiol - 67.6 pmol/L (41-159) in range, tad low
Test - 25 nmol/L (8.64-29) high range
Free Test calc 0.38 nmol/L (0.2-0.62) mid range
FAI 43.55 ratio (24-104) low ish
Prolactin - 262 mU/L (86-324) slighty high
DHEA Sulphate - 6.23 umol/L (2.41-11.6) low/mid
Progesterone - 0.17 nmol/L ( < 0.474) NORMAL!!!
DHT - ??? nmol/L (1.14-4.13) -awaiting results-
#########################
Right, made my mind up. Next experiment will be St John's Wort and/or Inositol. Having read a few of the PSSD recoveries here and feeling like laying off the "proper" pharmaceuticals for a while this seems like it'll be worth a stab. My thinking is just fiddling with 5HTA receptors for six weeks or so then stopping, see what it does. I wonder if my chronic use of hayfever medicine (fexofenadine - took 90mg/day for about three years pre-PFS) screwed up these receptors for me, and something to do with that has led to either PFS or aspects of it.
Putting together something vaguely like Beetlebum and PharmD did, it looks to be a toss up between SJW and Inositol. Maybe both can be run together? Alternate weeks even? Idk. Let's find out.
Thinking it could be:
wk1 - SJW 900mg/day
wk2 - SJW 900mg/day (but 4 day break)
wk3 - Inositol 18g/day, Monday single Berberine tablet, Friday 1.5g Choline
wk4 - SJW 1350mg/day
wk5 - Inositol 18g/day, Monday single Berberine tablet, Friday 1.5g Choline
wk6 - SJW 1350mg/day
wk7 - Inositol 18g/day, Monday single Berberine tablet, Friday 1.5g Choline
... [continue until feeling like benefits taper off then stop dead, max 8 weeks.]
Anyone fancy having a think? I'm not sure if I do improve any from cipro (or even fexofenadine) but I know I've had no allergies since the start of the year, and I used to be fiercely allergic to my cat. Would this also go any way to explaining temporary cipro recoveries?
Of course any and all suggestions welcome. Alongside this I'll be running Gillian Hamer's diet and probiotics, the gut protocol, paleo diet and gym 4-5 days/week plus 2x30-60 minute runs/week.
Thinking also of running the following bloods towards the end of the cycle:
DHEA-S
FSH
LH
Test
Free Test
SHBG
FAI
Oestradiol
Prolactin
Albumin
Cheers everybody!
EDIT - I'll try and limit masturbation throughout, have been indulging recently. Have done a LOT of reading on SJW, but not a lot of understanding with it. Wish I had Helen or Boris on speed-dial...
It does look like it increases prolactin, so I'll not do any more to that with excessive masturbation. In my SMALL/probably wrong understanding it works by a different mechanism to upregulate 5HT-x receptors by blocking seratonin recycling and also levels out GABA. I'd imagine some feeling like Beta Blockers? I never took them, but a friend described them as "feeling like always being at 30% and you never move"
I mean, there's more research on SJW than I could read in a year I think, but that's my summary. Have a little dump:
5HT2A Receptors: Anxiety, Fatigue, Sleep Problems & CIRS - SelfHacked
5-HT1A Receptor: The "Single" & "Self-Transcendent" Receptor - SelfHacked
5-HT2C Explains Anxiety, Depression, Weight Gain & More - SelfHacked
Beta-2 adrenergic receptor - Wikipedia
I'm *thinking* SJW primarily affects 5HT2C and Beta-Andrenergic receptors. I'm totally not done researching what Inositol is supposed to do, best I have is "similar but more to do with signalling between things" so I'm not yet sure if alternate weeks is best, if just running SJW 6 weeks then trying inosotol 6 weeks after (or vice versa) might do, but I gotta start somewhere I suppose.
Sod it, I'm feeling brave, I'll prod @Helen and @Boris for an ask.
Recoveries (PSSD) I'm looking at are:
kramdrol (St. John’s Wort)
Beetlebum (St. John’s Wort)
PSSD (Inositol)
PharmD (Inositol)
Hopefully this is worth a gander. SJW and those two types of receptors seem to touch and account for SO much. I'm also so so suspicious my chronic use of fexofenadine over a few years has screwed with this a bit, but there have been recoveries with Trazodone (or at least one) which I think does similar to SSRIs at high doses, and antihistamines at lower ones.
Oh god if only I had one of you guys' brains for a day seriously...
EDIT - Pre-bloods are here for reference:
### Pre-SJW/Inositol bloods ###
Test - 25 nmol/L (8.64-29) high range
Cortisol - 525 nmol/L (166-507) over range
Test/Cort ratio 0.05
Albumin - 45.2g/L (35-50) ok ish
SHBG - 57.4 nmol/L (18.3-54.1) over range
FSH - 4.85 IU/L (1.5-12.4) low-mid
LH - 5.16 IU/L (1.7-8.6) perfectly mid-range
Oestradiol - 67.6 pmol/L (41-159) in range, tad low
Test - 25 nmol/L (8.64-29) high range
Free Test calc 0.38 nmol/L (0.2-0.62) mid range
FAI 43.55 ratio (24-104) low ish
Prolactin - 262 mU/L (86-324) slighty high
DHEA Sulphate - 6.23 umol/L (2.41-11.6) low/mid
Progesterone - 0.17 nmol/L ( < 0.474) NORMAL!!!
DHT - ??? nmol/L (1.14-4.13) -awaiting results-
#########################
Last edited: