@stupidfreak
" feel defective,pathetic as a man(i would even prefer beqing a eunuch rather than this)and i want to start MtF HRT and have sex reassigment surgery.This seems to me the only way to live a semi-pleasant life and the other option is only suicide.However,im afraid that my endocrine system is so fucked up that i wont be able to respond to it."
This is an extremely drastic option. As a genetically born male... If we think PFS is bad... think about the side effects of spironolactone and estrogen-therapy. And top and bottom surgeries. We've been feminized to a degree. Further feminization is unlikely the answer. We went against our biological nature, and correcting it back to homeostasis is a more direct answer. Fasting has helped me a lot (I feel more human again), and the other things in my plan will too (discussed in hackstasis).
It's HARD man, it really is. I've gone through two major adverse drug reactions - one of them I was 20 years old. I nearly lost my life and was too crazy to actually see it (I don't like admitting this, but its true). "Solving" your issues by transitioning would necessitate more and more endocrine drugs (and psyche drugs). Suicide rates as mentioned by someone else here are HIGH in the transgender community. Possibly higher than bipolar.
Drugs are tools. But the wrong drugs lead to more and more drugs, and more and more side effects, and more and more identity crises. If you truly want to do it, then I can kind of understand. I'm not judgemental in that respect. But, you're 23 man. I didn't really know who I was (kind of) till I was like 26 or 27.
I survived one horrific adverse drug event, setting off months-long mania (Effexor XR). So as demoralizing and depressing as PFS is -- I have the balls to solve it. You can too. Trust me you don't want 3 and 4 and 5 psychiatric diagnosis in addition to gender reassignment + PFS. These additional diagnoses though caused situationally, would likely follow.
It's harder than it seems. People who know at 15 or 16 years old might be happier. Keep in mind, people have de-transitioned too. People who were dead-set on getting it.
W.r.t. RU. Drugs are used everyday everywhere in the world for other reasons than the original patent/purpose (which can cause a lot of issues). Sometimes it's worth it though. Did you know that cocaine was used as a surgical anesthetic in the past? Or that there used to be prescription methamphetamine for ADHD (desoxyn)? "Crystal meth" (street grade) is obviously used for other things now (getting people hooked to drugs). High dose caffeine can stop some allergic reactions?
By the way there is someone who transitioned supposedly because of PFS. "Mandi McKee", you mentioned them.
We all need to learn to live with regrets.