Sulphoraphane as an inducer of 3 alpha hsd.( DHT to metabolites conversion) HAIRLOSS, PFS, COPD, CANCER PSSD

[tallglass13]

My dad's color in his face is more pink, I mentioned to him last night at my son's basketball practice. He said he has been taking 2 sulphoraphane's daily. Been about 3 weeks or more. He is 65. he does a breathing treatment at night. He still works. We go to the river 3 times a year to ride our Seadoo's. So he is somewhat active. He is always blowing out C02. I used to tell him to not do that and do Butenko's technique. But after learning from Gbold, I now know my dad HAS to breath out through his mouth, to blow out the C02 he is retaining since his body is in low oxygenation d/t his free radicals from cigarette smoking all his life. I now have direction in how to treat him to help reverse COPD.

 

[Helen]

My dad's color in his face is more pink, I mentioned to him last night at my son's basketball practice. He said he has been taking 2 sulphoraphane's daily. Been about 3 weeks or more. He is 65. he does a breathing treatment at night. He still works. We go to the river 3 times a year to ride our Seadoo's. So he is somewhat active. He is always blowing out C02. I used to tell him to not do that and do Butenko's technique. But after learning from Gbold, I now know my dad HAS to breath out through his mouth, to blow out the C02 he is retaining since his body is in low oxygenation d/t his free radicals from cigarette smoking all his life. I now have direction in how to treat him to help reverse COPD.

As oxygen gets in , CO2 will be out on its own. If your dad is getting pink, that is excellent. I hope he recovers completely

 

[Helen]

Modulation of Experimental Herpes Encephalitis-Associated Neurotoxicity through Sulforaphane... - Europe PMC Article - Europe PMC Many people with PFS and POIS , since their glutathione goes down get mono or EBV . This can cause chronic activation of NADPH oxidase. And thus inflammation. As you can see they are using sulphoraphane to get rid of inflammation and upregulate glutathione enzymes

 

[brongfogboy]

Man, crazy, there is a recovery on propeciahelp from years ago with sulforaphane. He used this product and he also made a very long explanation why it helped. BroccoProtect™

I bought the same product 1-2 years ago but did not dare to try it, now its time to use it, lol.

If you still have the link would you mind sharing it? I cannot find this account anywhere

 

[freeflow]

If you still have the link would you mind sharing it? I cannot find this account anywhere

The link works for me, try again.

 

[bruschi11]

The link works for me, try again.

He’s looking for the story not the product I think.

 

[freeflow]

Ah ok. I was looking for it to link it but I could not find it either. It was a very interesting recovery though, he was explaining his recovery from the epigenetic point of view which is true because with any recovery protocol you change your gene and protein experssion, enzymes.

 

[TubZy]

Someone really needs to give this a go, its pretty cheap and easy, would be interesting to see

 

[MNK99]

Can someone take it while on PCT or while on R-Andro/4-Andro?
While on RU solo?

 

[freeflow]

Someone really needs to give this a go, its pretty cheap and easy, would be interesting to see

Im using it the last 3--4 days and feeling good. Definitely better than usual pfs. But u also take 1 capsule of r andro every 3-4 days, dont feel too well on those days but have some minor snap backs.

 

[Trump_1776]

Sulphoraphane was found to decrease AR protein signaling in LNCAP cell. In other words it reduces androgen receptors - especially in the prostate. Which is why it was looked at for treatment of cancer.

So yes it would aid in male pattern baldness but it still falls under the androgen angle.

As far as PFS, there is an undeniable trend that by re-exposing ourselves to a similar product (progesterone, licorice, etc)othat effects AR signaling, and by proxy running a PCT, that people get better.

Its like stopping finasteride was an electrical shock to a car which drained a car battery, and only by shocking it again with a jump start do we get up and running again.

But anyways, you can find many articles explaining it, just search sulf. With LNCAP and read

 

[TubZy]

Sulphoraphane was found to decrease AR protein signaling in LNCAP cell. In other words it reduces androgen receptors - especially in the prostate. Which is why it was looked at for treatment of cancer.

So yes it would aid in male pattern baldness but it still falls under the androgen angle.

As far as PFS, there is an undeniable trend that by re-exposing ourselves to a similar product (progesterone, licorice, etc)othat effects AR signaling, and by proxy running a PCT, that people get better.

Its like stopping finasteride was an electrical shock to a car which drained a car battery, and only by shocking it again with a jump start do we get up and running again.

But anyways, you can find many articles explaining it, just search sulf. With LNCAP and read

I found the opposite. It wasn't due to sulforaphane suppressing AR signalling which made it beneficial for prostate cancer, it was the inhibition of the enzyme prior to that called histone deacetylase 6 (HDAC6) which is up-regulated in cancer. Inibiting that enzyme influences the AR, not the other way around. Prostate cancer is very complicated anyways, that is why T, DHT and estrogen all play a role.

Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6. - PubMed - NCBI

High consumption of cruciferous vegetables is associated with a reduced risk of prostate cancer in epidemiological studies. There is preliminary evidence that sulforaphane, derived from glucoraphanin found in a number of crucifers, may prevent and induce regression of prostate cancer and other malignancies in preclinical models, but the mechanisms that may explain these effects are not fully defined. Recent reports show that sulforaphane may impair prostate cancer growth through inhibition of histone deacetylases, which are up-regulated in cancer. Indeed, one of these enzymes, histone deacetylase 6 (HDAC6), influences the acetylation state of a key androgen receptor (AR) chaperone, HSP90. AR is the central signaling pathway in prostate cancer, and its inhibition is used for both prevention and treatment of this disease. However, it is not known whether the effects of sulforaphane involve suppression of AR. We hypothesized that sulforaphane treatment would lead to hyperacetylation of HSP90 and that this would destabilize AR and attenuate AR signaling. We confirmed this by demonstrating that sulforaphane enhances HSP90 acetylation, thereby inhibiting its association with AR. Moreover, AR is subsequently degraded in the proteasome, which leads to reduced AR target gene expression and reduced AR occupancy at its target genes. Finally, sulforaphane inhibits HDAC6 deacetylase activity, and the effects of sulforaphane on AR protein are abrogated by overexpression of HDAC6 and mimicked by HDAC6 siRNA. The inactivation by sulforaphane of HDAC6-mediated HSP90 deacetylation and consequent attenuation of AR signaling represents a newly defined mechanism that may help explain this agent's effects in prostate cancer.

 

[TubZy]

Sulphoraphane was found to decrease AR protein signaling in LNCAP cell. In other words it reduces androgen receptors - especially in the prostate. Which is why it was looked at for treatment of cancer.

So yes it would aid in male pattern baldness but it still falls under the androgen angle.

As far as PFS, there is an undeniable trend that by re-exposing ourselves to a similar product (progesterone, licorice, etc)othat effects AR signaling, and by proxy running a PCT, that people get better.

Its like stopping finasteride was an electrical shock to a car which drained a car battery, and only by shocking it again with a jump start do we get up and running again.

But anyways, you can find many articles explaining it, just search sulf. With LNCAP and read

IDK about a snap back from sulf, would be interesting, if even possible though. Not sure just by reducing reducing AR expression would cause it a snap back type effect, but it seems to work on other angles discussed earlier in this thread like increasing DHT metabolites. That is why someone should try it and the proper one that actually gets absorbed (the one/form linked in this thread).

The "proxy PCT" you are referring to is called a "snap back" here. This is what most of us talk about when ceasing use of things like ella, RU486, licorice root, progesterone etc. and getting better when coming off. You can just search the term "snap back" in the search bar there is loads of info on it or check the links in my sig.

 

[Trump_1776]

I found the opposite. It wasn't due to sulforaphane suppressing AR signalling which made it beneficial for prostate cancer, it was the inhibition of the enzyme prior to that called histone deacetylase 6 (HDAC6) which is up-regulated in cancer. Inibiting that enzyme influences the AR, not the other way around. Prostate cancer is very complicated anyways, that is why T, DHT and estrogen all play a role.

Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6. - PubMed - NCBI

High consumption of cruciferous vegetables is associated with a reduced risk of prostate cancer in epidemiological studies. There is preliminary evidence that sulforaphane, derived from glucoraphanin found in a number of crucifers, may prevent and induce regression of prostate cancer and other malignancies in preclinical models, but the mechanisms that may explain these effects are not fully defined. Recent reports show that sulforaphane may impair prostate cancer growth through inhibition of histone deacetylases, which are up-regulated in cancer. Indeed, one of these enzymes, histone deacetylase 6 (HDAC6), influences the acetylation state of a key androgen receptor (AR) chaperone, HSP90. AR is the central signaling pathway in prostate cancer, and its inhibition is used for both prevention and treatment of this disease. However, it is not known whether the effects of sulforaphane involve suppression of AR. We hypothesized that sulforaphane treatment would lead to hyperacetylation of HSP90 and that this would destabilize AR and attenuate AR signaling. We confirmed this by demonstrating that sulforaphane enhances HSP90 acetylation, thereby inhibiting its association with AR. Moreover, AR is subsequently degraded in the proteasome, which leads to reduced AR target gene expression and reduced AR occupancy at its target genes. Finally, sulforaphane inhibits HDAC6 deacetylase activity, and the effects of sulforaphane on AR protein are abrogated by overexpression of HDAC6 and mimicked by HDAC6 siRNA. The inactivation by sulforaphane of HDAC6-mediated HSP90 deacetylation and consequent attenuation of AR signaling represents a newly defined mechanism that may help explain this agent's effects in prostate cancer.

The inactivation by sulforaphane of HDAC6-mediated HSP90 deacetylation and consequent attenuation of AR signaling represents a newly defined mechanism that may help explain this agent's effects in prostate cancer.

Cool, but attenuation of AR signaling is attenuation of AR signaling. There is still a reduction. And we know very well now that when it comes to AR there is no strict local application. Systemically it just gets affected. Unless there is something I'm missing

 

[TubZy]

The inactivation by sulforaphane of HDAC6-mediated HSP90 deacetylation and consequent attenuation of AR signaling represents a newly defined mechanism that may help explain this agent's effects in prostate cancer.

Cool, but attenuation of AR signaling is attenuation of AR signaling. There is still a reduction. And we know very well now that when it comes to AR there is no strict local application. Systemically it just gets affected. Unless there is something I'm missing

Right...but what I'm saying is that sulf reduces AR in prostate cancer cells since HDAC6 is upregulated in cancer cells. So in this case of the study, inhibiting HDAC6/AR in prostate cancer cells could actually be a good thing since they are upregulated in the first place. HDAC6 is upregulated because the cell is cancerous, you see what I'm saying?

Do you have any studies that just focus on regular human prostate cells not cancerous ones? All I found were prostate cancer cells studies in regards to sulf, which unless someone here had prostate cancer, not sure that would be all that accurate since certain enzymes would be upregulated....

Sulforaphane increases the efficacy of anti-androgens by rapidly decreasing androgen receptor levels in prostate cancer cells. - PubMed - NCBI
D,L-sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells

 

[Trump_1776]

Right...but what I'm saying is that sulf reduces AR in prostate cancer cells since HDAC6 is upregulated in cancer cells. So in this case of the study, inhibiting AR in prostate cancer cells could actually be a good thing. HDAC6 is upregulated because the cell is cancerous, you see what I'm saying?

Do you have any studies that just focus on regular human prostate cells not cancerous ones? All I found were prostate cancer cells studies in regards to sulf, which unless someone here had prostate cancer, not sure that would be all that accurate....

Sulforaphane increases the efficacy of anti-androgens by rapidly decreasing androgen receptor levels in prostate cancer cells. - PubMed - NCBI
D,L-sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells

Yeah I got what you're saying. But medication/herbs/minerals that effect AR signaling in the prostate aren't strictly limited to cancerous cells.

 

[Trump_1776]

Right...but what I'm saying is that sulf reduces AR in prostate cancer cells since HDAC6 is upregulated in cancer cells. So in this case of the study, inhibiting HDAC6/AR in prostate cancer cells could actually be a good thing since they are upregulated in the first place. HDAC6 is upregulated because the cell is cancerous, you see what I'm saying?

Do you have any studies that just focus on regular human prostate cells not cancerous ones? All I found were prostate cancer cells studies in regards to sulf, which unless someone here had prostate cancer, not sure that would be all that accurate since certain enzymes would be upregulated....

Sulforaphane increases the efficacy of anti-androgens by rapidly decreasing androgen receptor levels in prostate cancer cells. - PubMed - NCBI
D,L-sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells

Im trying to explain myself but im on my phone snd platform via mobile is absolute trash.

 

[TubZy]

Yeah I got what you're saying. But medication/herbs/minerals that effect AR signaling in the prostate aren't strictly limited to cancerous cells.

OK, so like I said do you have a study on sulf affecting the AR that are not cancerous prostate cells with already upregulated enzymes and receptors? I'm only asking since you made the claim pretty firmly

 

[TubZy]

Im trying to explain myself but im on my phone snd platform via mobile is absolute trash.

What's wrong with it? Only issue right now is the edit button only appears on landscape mode. You know you can use the desktop mobile version by just selecting it on your browser options and it's identical to the PC version site.

 

[Maxin]

Is this the same as DIM? I remember reading a pass guy that was cured of pass from dim a while back. Can’t remember where?