Testosterone decreases brain 5AR1 and lowers allopregnenolone.

[Helen]

Changes in brain testosterone and allopregnanolone biosynthesis elicit aggressive behavior


this seems exactly what finasteride does.


this is why @Cdsnuts steered people away from TRT and rec'd LH and FSH increasing herbs.

big difference to increase LH with herbs and decrease LH with testosterone.

LH does not only secrete testosterone but progesterone also.



Notice that they used estrogen plus progesterone to recover brain 5AR1 and allopregnenolone.

 

[TubZy]

Changes in brain testosterone and allopregnanolone biosynthesis elicit aggressive behavior


this seems exactly what finasteride does.


this is why @Cdsnuts steered people away from TRT and rec'd LH and FSH increasing herbs.

big difference to increase LH with herbs and decrease LH with testosterone.

LH does not only secrete testosterone but progesterone also.



Notice that they used estrogen plus progesterone to recover brain 5AR1 and allopregnenolone.

What could mimic estrogen and prog from a herb perspective to verify if it works? Japanese knotweed and vitex maybe?

 

[Helen]

What could mimic estrogen and prog from a herb perspective to verify if it works? Japanese knotweed and vitex maybe?

tribulus increases FSH and LH> I think tribulus might be estrogenic. estrogen actually increases LH.

but I have to think about it. for cases. everything gets to complicated with all these cases.

may be just brain is fucked up in the same way for everyone, and metabolisms are just different on hair

since I mean we see slow oxidizers fast oxidizers, with zero problems like PFS>

some have calcification, others high cortisols. but not PFS.

I mean they are not optimal for sure, I mean people.

but they dont have PFS,


So this tells me that PFS is def neurosteroids related. and we cant just look at metabolisms

TEI is great at it. since they look at what brain tells them.

and they just force force until brain lets go.

but it is slow, may be we can force the same with hormones.


I mean a person gets crushed on fin from one pill.

same as PSSD people.

there are not many changes done there. it should be as easy to get him out, as he got himself in. really.


there is no calcification from one pill, there is no copper retention, there is just something happening in the brain, I think

Unless those who crashed from one pill all had low DHT to begin with, and may be just crashed their NADPH system and thus glutathione and redox and methylation just went off line. and can't get back on may be something got oxidized hard like b12 or something

 

[TubZy]

tribulus increases FSH and LH> I think tribulus might be estrogenic. estrogen actually increases LH.

but I have to think about it. for cases. everything gets to complicated with all these cases.

may be just brain is fucked up in the same way for everyone, and metabolisms are just different on hair

since I mean we see slow oxidizers fast oxidizers, with zero problems like PFS>

some have calcification, others high cortisols. but not PFS.

I mean they are not optimal for sure, I mean people.

but they dont have PFS,


So this tells me that PFS is def neurosteroids related. and we cant just look at metabolisms

TEI is great at it. since they look at what brain tells them.

and they just force force until brain lets go.

but it is slow, may be we can force the same with hormones.


I mean a person gets crushed on fin from one pill.

same as PSSD people.

there are not many changes done there. it should be as easy to get him out, as he got himself in. really.


there is no calcification from one pill, there is no copper retention, there is just something happening in the brain, I think

Unless those who crashed from one pill all had low DHT to begin with, and may be just crashed their NADPH system and thus glutathione and redox and methylation just went off line. and can't get back on may be something got oxidized hard like b12 or something

Right, I think we did talk about that from the beginning I think it was @Admiral who kept saying non PFS and PFS people are no different on hair tests

 

[TubZy]

Or also GR gets upregulated or downregulated in brain

 

[joekool]

tribulus increases FSH and LH> I think tribulus might be estrogenic. estrogen actually increases LH.

Where do you see estrogen increases LH?

 

[D4n]

Think this is a promising route with 5ar inhibition causing HPA Axis dysfunction Central 5-alpha reduction of testosterone is required for testosterone's inhibition of the hypothalamo-pituitary-adrenal axis response to restraint s... - PubMed - NCBI

 

[HerrFisch]

Manganese increases both Lh and FSH

 

[TubZy]

For GR you can try two things. Prednisone or RU. One blocks GR the other will act as an agonist. See how you feel during and after. @Helen

 

[freeflow]

tribulus increases FSH and LH> I think tribulus might be estrogenic. estrogen actually increases LH.

but I have to think about it. for cases. everything gets to complicated with all these cases.

may be just brain is fucked up in the same way for everyone, and metabolisms are just different on hair

since I mean we see slow oxidizers fast oxidizers, with zero problems like PFS>

some have calcification, others high cortisols. but not PFS.

I mean they are not optimal for sure, I mean people.

but they dont have PFS,


So this tells me that PFS is def neurosteroids related. and we cant just look at metabolisms

TEI is great at it. since they look at what brain tells them.

and they just force force until brain lets go.

but it is slow, may be we can force the same with hormones.


I mean a person gets crushed on fin from one pill.

same as PSSD people.

there are not many changes done there. it should be as easy to get him out, as he got himself in. really.


there is no calcification from one pill, there is no copper retention, there is just something happening in the brain, I think

Unless those who crashed from one pill all had low DHT to begin with, and may be just crashed their NADPH system and thus glutathione and redox and methylation just went off line. and can't get back on may be something got oxidized hard like b12 or something

In the end the protocol will be to cure PFS first with cdnuts method, then cure your other problems with mineral balancing

 

[Helen]

In the end the protocol will be to cure PFS first with cdnuts method, then cure your other problems with mineral balancing

cdnuts protocol is approved here. and it makes sense.

 

[bruschi11]

In the end the protocol will be to cure PFS first with cdnuts method, then cure your other problems with mineral balancing

There’s going to be a collection of things for guys to look at and go after including nutritional balance (not just minerals, but aminos, fats, vitamins), pathogens, fungus/mold, toxicities, immune system/beneficial bacteria and really not much else.

CDS’s herbs affect immune system, beneficial bacteria and nutritional balance which also mitigates the negatives like pathogens and fungus.

I think his method just isn’t strong enough to make major differences very quickly though unless you do a lot of fasting and “priming” the body for it.

 

[TubZy]

tribulus increases FSH and LH> I think tribulus might be estrogenic. estrogen actually increases LH.

but I have to think about it. for cases. everything gets to complicated with all these cases.

may be just brain is fucked up in the same way for everyone, and metabolisms are just different on hair

since I mean we see slow oxidizers fast oxidizers, with zero problems like PFS>

some have calcification, others high cortisols. but not PFS.

I mean they are not optimal for sure, I mean people.

but they dont have PFS,


So this tells me that PFS is def neurosteroids related. and we cant just look at metabolisms

TEI is great at it. since they look at what brain tells them.

and they just force force until brain lets go.

but it is slow, may be we can force the same with hormones.


I mean a person gets crushed on fin from one pill.

same as PSSD people.

there are not many changes done there. it should be as easy to get him out, as he got himself in. really.


there is no calcification from one pill, there is no copper retention, there is just something happening in the brain, I think

Unless those who crashed from one pill all had low DHT to begin with, and may be just crashed their NADPH system and thus glutathione and redox and methylation just went off line. and can't get back on may be something got oxidized hard like b12 or something

I mean if it was just LH you could just take HCG which was tried before on PH

 

[joekool]

LH is a topic because I mentioned it in my log thread about how I planned to use low dose HCG and I posted this link:

Penile Growth in Response to Human Chorionic Gonadotropin (hCG) Treatment in Patients with Idiopathic Hypogonadotrophic Hypogonadism

I'll be doing 250iu 3 days a week for 24 weeks for my PCT

 

[Helen]

LH is a topic because I mentioned it in my log thread about how I planned to use low dose HCG and I posted this link:

Penile Growth in Response to Human Chorionic Gonadotropin (hCG) Treatment in Patients with Idiopathic Hypogonadotrophic Hypogonadism

I'll be doing 250iu 3 days a week for 24 weeks for my PCT

LH is a topic because you are going to take HCG ? what?

LH was mentioned since you are taking testosterone and suppress it with it.

and LH secretes not only testosterone but also progesterone.

Do you even read the topic of this thread.

 

[Aflac94]

tribulus increases FSH and LH> I think tribulus might be estrogenic. estrogen actually increases LH.

but I have to think about it. for cases. everything gets to complicated with all these cases.

may be just brain is fucked up in the same way for everyone, and metabolisms are just different on hair

since I mean we see slow oxidizers fast oxidizers, with zero problems like PFS>

some have calcification, others high cortisols. but not PFS.

I mean they are not optimal for sure, I mean people.

but they dont have PFS,


So this tells me that PFS is def neurosteroids related. and we cant just look at metabolisms

TEI is great at it. since they look at what brain tells them.

and they just force force until brain lets go.

but it is slow, may be we can force the same with hormones.


I mean a person gets crushed on fin from one pill.

same as PSSD people.

there are not many changes done there. it should be as easy to get him out, as he got himself in. really.


there is no calcification from one pill, there is no copper retention, there is just something happening in the brain, I think

Unless those who crashed from one pill all had low DHT to begin with, and may be just crashed their NADPH system and thus glutathione and redox and methylation just went off line. and can't get back on may be something got oxidized hard like b12 or something

Keep going!

 

[Ocguy]

I mean if it was just LH you could just take HCG which was tried before on PH

Hcg didnt do dick for me.. my balls got heavy and full but zero effect on libido.. totally fucked up.. brain was just as disconnected as always

 

[joekool]

@Ocguy what was your dosage and timeframe? Every try HMG or triptorelin ?

 

[K8668B]

tribulus increases FSH and LH> I think tribulus might be estrogenic. estrogen actually increases LH.

but I have to think about it. for cases. everything gets to complicated with all these cases.

may be just brain is fucked up in the same way for everyone, and metabolisms are just different on hair

since I mean we see slow oxidizers fast oxidizers, with zero problems like PFS>

some have calcification, others high cortisols. but not PFS.

I mean they are not optimal for sure, I mean people.

but they dont have PFS,


So this tells me that PFS is def neurosteroids related. and we cant just look at metabolisms

TEI is great at it. since they look at what brain tells them.

and they just force force until brain lets go.

but it is slow, may be we can force the same with hormones.


I mean a person gets crushed on fin from one pill.

same as PSSD people.

there are not many changes done there. it should be as easy to get him out, as he got himself in. really.


there is no calcification from one pill, there is no copper retention, there is just something happening in the brain, I think

Unless those who crashed from one pill all had low DHT to begin with, and may be just crashed their NADPH system and thus glutathione and redox and methylation just went off line. and can't get back on may be something got oxidized hard like b12 or something

I remember the day I took my first pill of propecia, a few hours later I couldn't get it up when I tried fantasizing sexual things in my head. I was fine later on and the next day and for on after that... Up until roughly 12+ months later when it permanently fucked me up. Could very well be neurosteorid related.

 

[MCurtone]

This is certainly a factor. The problem is it's so hard to test neurosteroids on live subjects. You're playing in the dark. This is what a lot of people from raypeat forums are talking about.

For myself, I have a libido, dick works fine, although my sex drive is not as high as it used to be, it could simply be because I've been with the same person for 3 years and its less exciting. When I am around other girls I can become very aroused.

My issues are seemingly cognitive, brain fog, energy issues, etc. I found overall that reducing inflammation helped a lot. Something regarding inflammation plays a role on neurosteroids and brain 5ar.

Taking 5a-dhp helped me quite a bit, but especially GHB. I'm not 100%, but I megadosed it to finally get good sleep and my stress response has been magnitudes better ever since. GHB is also known to increase allo and progesterone by 3-5 fold. Study below.

GABA(B) receptor-mediated increase of neurosteroids by gamma-hydroxybutyric acid. - PubMed - NCBI

For some reason 5ar in the brain is messed up from taking finasteride. I also did TRT and even took things like Dianabol. My sex drive was CRAZY high but my cognitive health was TERRIBLE. Zero focus, brain fog, no ability to think clear. Seems to be that the higher blood T and DHT is, the worse the neurosteroids are.

Things that help with brain 5ar are:

Caffeine
Glycine
GHB (potentially)
Anything that acts on the GABA A receptors really...

Currently my routine involves clearing the gut, cleaning the liver and nutrient density from raw animal products.

5a-dhp once in a while
GHB to sleep once in a while
Coffee enemas
MMS/ Chlorine Dioxide
Activated Charcoal
Raw Milk & Colostrum
Liver, etc.

I've made big improvments