Ulcerative Colitis / IBD

[Helen]

I am pro chelation, fasting, and eating well. I am not pro supplements or hormones.

For anyone sick with anything

1) fasting, juice fasting
2) zeolite or other chelators

3) my diet that I outlined

@gbolduev where is your diet outlined? I cant find it anywhere.

Can you please share the brands/products of chelators u use(d)?

Is PUFA bad in sea foods(fish, kelp etc.)?

What about the tzar vodka you take? From where do u order the ingredients to make the tzar vodka? I guess the tzsar vodka helps u stay balanced A LOT, by helping u to actually digest and absorb nutrients from food.

According to russian researchers sodium thiosulphate(combined with ascorbic acid) is the best chelator, this will take EVERYTHING out of you, heavy metals, minerals, probiotics, everything )))

More on sodium thiosulphate: https://www.youtube.com/watch?v=9EKXbeLK36o

I took STS, and I like it, but I found it be weak.

https://www.sciencedirect.com/science/article/pii/S0045653512005437

 

[Legna88]

I am pro chelation, fasting, and eating well. I am not pro supplements or hormones.

For anyone sick with anything

1) fasting, juice fasting
2) zeolite or other chelators

3) my diet that I outlined

@gbolduev where is your diet outlined? I cant find it anywhere.

Can you please share the brands/products of chelators u use(d)?

Is PUFA bad in sea foods(fish, kelp etc.)?

What about the tzar vodka you take? From where do u order the ingredients to make the tzar vodka? I guess the tzsar vodka helps u stay balanced A LOT, by helping u to actually digest and absorb nutrients from food.

According to russian researchers sodium thiosulphate(combined with ascorbic acid) is the best chelator, this will take EVERYTHING out of you, heavy metals, minerals, probiotics, everything )))

More on sodium thiosulphate: https://www.youtube.com/watch?v=9EKXbeLK36o

I took STS, and I like it, but I found it be weak.

https://www.sciencedirect.com/science/article/pii/S0045653512005437

@gbolduev where is your diet outlined? I cant find it anywhere.

Can you please share the brands/products of chelators u use(d)?
where is your diet outlined? I cant find it anywhere.

Can you please share the brands/products of chelators u use(d)?

Is PUFA bad in sea foods(fish, kelp etc.)?

What about the tzar vodka you take? From where do u order the ingredients to make the tzar vodka? I guess the tzsar vodka helps u stay balanced A LOT, by helping u to actually digest and absorb nutrients from food.

 

[Aleksandr]

EDTA is that the stuff used to kill candida?

 

[HerrFisch]

EDTA is that the stuff used to kill candida?

EDTA is a powerfull chelator.
Im not sure if it was Gbold or someone else but if you chelate your copper, candida will go too.

 

[Aleksandr]

EDTA is that the stuff used to kill candida?

EDTA is a powerfull chelator.
Im not sure if it was Gbold or someone else but if you chelate your copper, candida will go too.

Wow interesting. I might have to try this and zeolite


Something else too. Ccws: https://blog.candidacleanser.com/candida-cleanser-protocol

 

[dante]

EDTA is that the stuff used to kill candida?

EDTA is a powerfull chelator.
Im not sure if it was Gbold or someone else but if you chelate your copper, candida will go too.

Wait, i thought copper being a potent anti-fungal will kill candida. I think he said that copper bio-unavailability causes candida since copper is kept in liver due to lack of ceruloplasmin and other carrier proteins. If you chelate copper too much, you might get myelin related issues.

 

[Canari]

EDTA is that the stuff used to kill candida?

EDTA is a powerfull chelator.
Im not sure if it was Gbold or someone else but if you chelate your copper, candida will go too.

Wait, i thought copper being a potent anti-fungal will kill candida. I think he said that copper bio-unavailability causes candida since copper is kept in liver due to lack of ceruloplasmin and other carrier proteins. If you chelate copper too much, you might get myelin related issues.

I guess is you chelate copper, it goes out of the organs where it was stocked, and then kills candida?
And then we should also eat food high in copper, which is not that difficult.

About myelin, what do you mean by chelating too much? Too much at a time and have toxicity? Or chelate up to the point to become depleted?

 

[dante]

About myelin, what do you mean by chelating too much? Too much at a time and have toxicity? Or chelate up to the point to become depleted?

Chelating up to the point to become depleted. Long term copper deficiency starts causing neurological issues in animals. Also, copper bound ferroxidase proteins like ceruloplasmin is what protects against iron toxicity and accumulation in organs(gbold has already written about it many times I guess).

 

[Canari]

About myelin, what do you mean by chelating too much? Too much at a time and have toxicity? Or chelate up to the point to become depleted?

Chelating up to the point to become depleted. Long term copper deficiency starts causing neurological issues in animals. Also, copper bound ferroxidase proteins like ceruloplasmin is what protects against iron toxicity and accumulation in organs(gbold has already written about it many times I guess).

That makes sense with my hair analysis result too... My iron is high and my copper low. As this is not my topic, well if you want to have a look at the results in my threat through my signature... I was surprised by my results!

 

[HerrFisch]

Very interesting article about Riboflavin. [mention]mattyb[/mention]

"It was surprisingly found that orally administered riboflavin, also known as vitamin B2, is capable of increasing the absolute and relative number of concentration of F. prausnitzii in human volunteers. Butyrate production was also enhanced. Furthermore, a synbiotic formulation was developed to stabilize F. prausnitzii under aerobic conditions, thus allowing the use of this highly oxygen-sensitive organism as probiotic."

https://www.google.com/patents/WO2014070014A1?cl=en

might be a reason for [mention]gbolduev[/mention] to come to the conclusion of missing b2 in UC.

It was found that selective stimulation of Faecalibacterium prausnitzii by riboflavin can be achieved using an amount of at least 0.01 to 2 mg per kg body weight per day to ensure that enough riboflavin reaches the large intestine/colon and not all is absorbed in the small intestine. The riboflavin dose found to be effective for the purpose of the present invention is about 50 times higher than the recommended daily intake (1.5 mg/day for adult men) and at least 10 times higher than the 6-10 mg/day for treating riboflavin deficiency

Very good survival rates after exposure of the bacteria to ambient air were obtained when riboflavin and cystein were supplemented with inulin- type oligosacchararides, resistant starch and wheat bran.

"A significant underrepresentation of F. prausnitzii was observed in UC patients when
compared to healthy controls. We also observed an inverse correlation between the amount
of F. prausnitzii and the disease activity. Our findings persisted, even after correcting for
fecal water content. These results suggest that dysbiosis plays also a role in UC pathogenesis,
and in particular points to the protective effects of F. prausnitzii against inflammation."

https://www.ncbi.nlm.nih.gov/pubmed/6106826
The colonic epithelium in ulcerative colitis: an energy-deficiency disease?

 

[HerrFisch]

Article about "How Mitochondria Regulate the Gut Microbiota"

Connections between high ROS - H2s - butyrate

Gut microbiota molecules, such as N-butyrate, are essential for controlling mitochondrial
oxidative stress and inflammatory responses, pathogen growth and adherence as well as in
improving metabolism and energy expenditure during exercise.


! N-butyrate can reduce colonic H2O2 levels and thus diminish oxidative damage
by increasing COX-2 activity. In summary, SCFA can
improve mitochondrial function by reducing ROS levels through various possible
mechanisms which can damage DNA and shorten telomeres which are both associated
with aging and mitochondrial dysfunction.

https://www.frontiersin.org/articles/10.3389/fphys.2017.00319/full

 

[mattyb]

Herr, have you tried out even doing some intermittent fasting with high quality high fat dairy? If you can find good butter like KiwiPure it will provide a ton of butyrate.

Those riboflavin dosages are insane. Sounds like you have to eat a ton to override urinary excretion of B2 to force it into colon.

You've been doing lots of reading - what's your current strategy?

 

[HerrFisch]

Herr, have you tried out even doing some intermittent fasting with high quality high fat dairy? If you can find good butter like KiwiPure it will provide a ton of butyrate.

Those riboflavin dosages are insane. Sounds like you have to eat a ton to override urinary excretion of B2 to force it into colon.

You've been doing lots of reading - what's your current strategy?

No fasting yet.

And my goal right now is to make sure my body can produce enough butyrate on its own. I dont think supplementing / 5% of butter butyrate can work as good and as long as if the body can produce it on its own.

Yeah those b2 dosages are pretty high. Its just one way of increasing its count though. In combination with others, 100mg might be better than nothing

Current strategy is getting rid of copper. (chelation / increasing ceruloplasmin)
With manganese 15 zinc 40, molybdenum 150 & b2 100, carnosine 1000, artichoke extract, milk thistle.
And Im testing my hair again. Just to be sure.

For UC I lowered my Mesalamine dosage with the thought of getting some space to let the good ones grow.
Apparently it works similar to antibiotics as in modulating the gut microbiome.
+ Im trying my best to increase butyrate producers and the good ones in general.
With Inuline, isomalto-oligosaccharides, pectin, FOS, xylitol, sorbitol.


Its funny that everything I avoided for long times, I'm using now to increase butyrateproducers.

I had problems after eating chocolate with milk in it, lactose in general, apples, sorbitol gums.
But it was gas only. So I stopped everything the last 3-4 years but ate some dark chocolate without milk (85%). [But high in copper ]

And now I eat 3 apples, 10 sorbitol gums, pure milk chocolate and there is nothing . Im pretty sure lactose intolerance is often just bad mucosa and bacterial disbiosis.


I had a flare last year when I didnt know anything about problems in UC and gut bacteria. Back then I was using a Pre-workout.
And oddly enough, after every workout with this pre workout supplement, my flare seemed to be lowered. I could have blood and diarrhea all day. But after the workout with this pre workout supplement, it got noticeably better.

Guess what is in there for the taste and sweetness. vitafiber -> isomalto-oligosaccharides. Its only ~2g. But made a noticeably difference back then!

And now this year another flare which I stopped completely with this time high dose inuline.

And now I read a lot about that topic and its not only a good coincidence. Even in connection with your input on the mitochondria it makes even more sense. (Or just because of your input!)

 

[HerrFisch]

[mention]mattyb[/mention] what do you think about L+ Lactic acid in my case? (kefir etc)

 

[mattyb]

Huh, could have sworn I replied to your last post. Oh well. Anyway, I really like the current strategy! Sounds like a good plan.

I think Kefir could be worth experimenting with. I've certainly heard some good things about it from a few people with Crohn's that I've talked to. More consistent BMs seem to be the most common comment I hear, and that's always a good sign.

 

[HerrFisch]

Ha no problem You dont need to answer my questions if you dont have time. I will find the answer on my own, its just going to be faster with you and you probably got some good input too [mention]mattyb[/mention]

With lots of reading I got this big picture about UC now in my mind, though now I'm searching for references, quotes, articles, studies to prove my thoughts

Do you think its possible that if butyrate for CoA / CoA from butyrate is missing, the mitochondria changes to produce more lactate to lower the intestinal ph with that lactate? Therefore improving the circumstances for butyrate producing bacteria to grow? As l-lactate is precoursor to butyrate.

Because butyrate acts in colon cells as down and upstream of acetyl-CoA synthesis. And maybe my pyruvate is that high because of missing acetyl coA? So that the way to produce lactate is much more easy.

And with me testing palmitic acid, which acts as a energy source / acetly coA, but not lowering the intestinal pH for bacteria.

I remember Gbold saying that cancer is a state in which the body does not know if to go into acid / alkalosis.
(http://www.sciencedirect.com/science/article/pii/S0306987701913350)

If you take this quote out of that article :
"It has been known for decades that cancer cells produce excessive amounts of lactic acid. "

So dysfunctional mitochondria because of missing SCFA for CoA, high pyruvate, increased lactic acid production.

Gbold said "for cancer you need to change between the two. From Acidosis in alkalosis, into acidosis and back. Until everything is done.
But in cancer the body is in a conflict of those two options.
(And in cancer lactate gets burned via Oxphos driving the growth of tumors)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478457/

UC is maybe only one site of this whole mess. And butyrate is know for anti colon cancer.

Thus, increased mitochondrial fission is sufficient to induce oxidative stress in the tumor microenvironment and defects in oxidative mitochondrial metabolism (OXPHOS, as seen by immuno-blot analysis), thereby promoting a catabolic phenotype, which results in the over-production of the onco-metabolite, L-lactate.

In UC the body does 1 thing. Increase Lactic acid production to lower intestinal ph.
That happens on its own because of missing coA. In favor of SCFA producers.

After acidification of the gut, restored gut homeostasis, normal working krebs cycle, the lactic acidosis will be gone.

+Mitochondrial fission will be fixed as butyrate induces DRP-1 mitochondrial fusion & apoptosis in human cancer cells.

http://www.sciencedirect.com/science/article/pii/S1567724913002559

In the long term, the FOS-induced increase in intestinal lactic acid-producing bacteria was lost, but the butyrogenic properties of FOS were maintained. (http://jn.nutrition.org/content/129/12/2231.short)

"However, when two E. hallii strains and one A. caccae strain were grown in separate cocultures with a starch-utilizing Bifidobacterium adolescentis isolate, with starch as the carbohydrate energy source, the L-lactate produced by B. adolescentis became undetectable and butyrate was formed."
(http://aem.asm.org/content/70/10/5810.short)

"In this respect, it is noteworthy that higher proportions of butyrate are synthesized by the same microfloras when carbon flux is increased through modulation of the dilution rate (in vitro; Sharp and Macfarlane 2000) or of the transit time (in vivo; El Oufir et al. 1999) or when the continuous culture of faeces is slightly acidified."


For me thats continuously going in circles in UC. And medications just act like a break for some actions.

[mention]mattyb[/mention] Do you agree?

 

[Goose12]

My father had UC and passed away from colon cancer. I wish I knew what I know now, 10 years ago maybe I could have helped him.

5 or so years ago I read a story about a guy who cured himself by doing a juice fast on just cabbage juice. The theory was the cabbage juice lined the intestines and the fast gave them a chance to heal.

Also read about a recovery where someone fasted and drank sauerkraut juice on a water fast. The theory was the Probiotics and lactic acid allowed your colon to heal.

I don't know if this has been mentioned yet I just thought I would put it out there.

 

[opiath]

How high have you tried going with methylb12?

Doses of 5mg-20mg ramp up methylation a lot.
This heals epithelial tissues very fast and puts a lot of potassium into the cells.
It will also improve your glutathione recycling.
When you take b2 with it, you don't need huge doses of methyl-folate because the folate is recycled by FAD.

You also chelate a lot of copper while methylating because of increased synthesis of adrenaline and acetylcholine (as long as you have manganese).
When adrenaline and acetylcholine are up, ceruloplasmin can go up.

I suggest you read this summary. It is very informative:
http://howirecovered.wpengine.com/active-b12-therapy-faq/

 

[HerrFisch]

My father had UC and passed away from colon cancer. I wish I knew what I know now, 10 years ago maybe I could have helped him.

5 or so years ago I read a story about a guy who cured himself by doing a juice fast on just cabbage juice. The theory was the cabbage juice lined the intestines and the fast gave them a chance to heal.

Also read about a recovery where someone fasted and drank sauerkraut juice on a water fast. The theory was the Probiotics and lactic acid allowed your colon to heal.

I don't know if this has been mentioned yet I just thought I would put it out there.

Sorry to hear that.

Yes I think cabbage juice and fasting could really go well hand in hand. I think thats something that [mention]mattyb[/mention] would agree on.

Thank you!

 

[HerrFisch]

How high have you tried going with methylb12?

Doses of 5mg-20mg ramp up methylation a lot.
This heals epithelial tissues very fast and puts a lot of potassium into the cells.
It will also improve your glutathione recycling.
When you take b2 with it, you don't need huge doses of methyl-folate because the folate is recycled by FAD.

You also chelate a lot of copper while methylating because of increased synthesis of adrenaline and acetylcholine (as long as you have manganese).
When adrenaline and acetylcholine are up, ceruloplasmin can go up.

I suggest you read this summary. It is very informative:
http://howirecovered.wpengine.com/active-b12-therapy-faq/

Hey opiath, nice to see you here

I only went up to 0,5mg of b12.
I get acne on my neck if I increase my b12 dosage or take b12 without folate.

Nice find, Im going to read it.

How are your problems ?