Re: Mitochondrial problems.
<r><QUOTE author="HerrFisch" post_id="895" time="1507651229" user_id="114"><s>
HerrFisch post_id=895 time=1507651229 user_id=114 said:
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And whats with B1, intracellular Ph balancing, PFK, high ratio of NAD/NADH,high chance of disrupted TPP/PFK ? Drop all that? <br/>
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I know that UC people often do have urgency. I had this too. But only in flare ups. And I even had several years without any urgency. I just dont think that urgency has something to do with UC. Maybe rather consequential damages triggered from UC.<br/>
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Or something like you told me at first with TPP/PFK but together with my UC leads to my problems.<br/>
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"The palmitate is working because it promotes mitochondrial apoptosis by enhancing oxidative stress on the mitochondria"<br/>
Is there any other way to help this? <br/>
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From my doc I got that I have damaged mitochondria. So thats right but paired with over-replicating "bad" mitochondrias? -> the body tries to lower metabolism to stop the bad mitoch.?
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Yes, you get bad and incorrect information when you don't give a thorough and accurate history - that's what happens. History is everything.<br/>
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All that stuff about B1, B2, intracellular pH, PFK, NAD/NADH, ect. will have to be addressed once you fix the underlying issue of excessive mitochondrial fission. Luckily fasting is good for things like pH, NAD/NADH and chelating calcium and copper, and good for decreasing mito fission. So it will address a few things at once.<br/>
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Fixing the fission will still leave all the other issues to be corrected later, but decreasing mito fission has to happen first or all of that work will be in vain. So don't write off all that other stuff, it will be important in the future. But for now it's all about reducing fission. If I have to guess, your UC symptoms have improved while everything else has worsened specifically because your body has done a good job reducing mitochondrial fission and therefore metabolism. Do not fight against what your body is trying to do, it's trying to help things out. Help your body do it's thing by decreasing mito fission more and promoting mito fusion, fasting is the easiest path to make this happen.<br/>
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Fasting will help the most, as it will promote mitochondrial fusion, inhibit fission, and induce autophagy. I am not sure of other therapies that could help. I will do some more reading on this subject and figure it out for you. Fission is regulated by DRP1, but I am not sure of it's regulation - it's transcription and promotion is not incredibly well studied but it's being researched more and more. There are also genes that promote fusion that we would want to upregulate. But the easiest and most natural way to accomplish both is through fasting/autophagy.<br/>
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Avoid red light, nicotine and caffeine like the plague. They all promote mito fission and inhibit fusion, it will make your gut issues worse. They will make you feel better temporarily but they will cause UC to get worse and eventually make you feel worse in the long run. I have suspicions that palmitate may not be good either in the long run, but I am not sure yet, I will read more. Palmitate can promote fission, but it can also kill mitochondria. It may depend on the tissue and the conditions of the mitochondria prior to administration.<br/>
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Just to clarify things:<br/>
In most inflammatory diseases there is excessive mitochondrial fission. This means the mitochondria replicate within the effected cells to an excessive amount. Mitochondria produce many reactive oxygen species as a natural part of ATP synthesis which need to be cleaned up by things like CuZnSOD, MnSOD, glutathione, thioredoxin, etc. When there are too many mitochondria, those ROS neutralizing molecules can't be produced/recycled fast enough, and those ROS go on to create more complex and larger peroxides, often reacting with heavy metals, that damage tissues. In response to this, the body decreases metabolism to help decrease fission in the tissues that are overproducing ROS, and as a side-effect the whole body's metabolism is lowered. This lowered metabolic state creates other problems (like bad pH, low NAD/NADH ratio, low thyroid, low adrenal), but these problems are not inherently as damaging as when tissues overproduce ROS, so it's a good trade-off to make. The body may also excrete and try to chelate heavy metals like iron and copper to minimize the damage they do when interacting with ROS and lipids (like turning PUFA into lipid peroxides). One way the body does this is by placing iron into ferritin, where it can't be oxidized - this is one reason why nearly all inflammatory diseases are characterized by high ferritin (but ferritin will be low in people who don't have a ton of iron in their system, so it's not like that for everyone).<br/>
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It's not all about regulating "bad" mitochondria, but all mitochondria. Too many mitochondria is bad, very bad. Mitochondria are also more likely to be defective when there are too many of them (because the excessive ROS damages the mitochondria as well).<br/>
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You can see how this would create a pretty horrible feedback loop to be stuck in. Metabolism in one tissue is too high, so the body lowers metabolism everywhere. But it can't lower it enough on it's own because we keep feeding it energy to consume. Low overall metabolism harms other tissues, making recovery impossible. Then we do things like eating that boost metabolism, and it makes us feels better but worsens primary symptoms. This cycles needs to be broken. Fasting can break this cycle, and then once mitochondria numbers are back to normal, we can start to do things to heal our lowered metabolism without risking relapse of primary inflammatory disease.</r>
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