I see that Betaine in powder form is the preferable option. However, it seems not every one have access to it.
I wonder if those that contain Pepsin is something to concern.
Most people here are probably taking Betaine HCl that contains Pepsin.
I once read this from
4 Common Betaine HCl Mistakes
"There’s a huge selection of Betaine HCl supplements on the market right now. The strange thing is many don’t contain Pepsin.
The above screencap is part of one of my crazy digestion mind maps. In it, you should see that a stomach that doesn’t produce enough HCl also won’t make enough pepsin.
And without pepsin… we can’t break down proteins into the peptides required for proper absorption (that’s really important).
I will say, I have read a few examples of people that were sensitive to pepsin and if that’s the case for you, taking a Betaine HCl supplement without pepsin could help. However, from what I can tell in the literature it’s extremely rare.
So, if you’re taking Betaine HCl without pepsin, you may be wasting a lot of money and not seeing the full benefit you could experience from using one that does contain pepsin."
According to them, pepsin seems like a must thing to have when supplementing Betaine HCl.
Though, I don't know what they mean by being "sensitive to pepsin"...
Also, recalling what
Tyw said about it on RPF (
Metabolic Efficiency And Metabolic Rate - Doubt):
Personally, I do not experience a difference between pepsin-containing or non-pepsin-containing Betaine HCL. 30 gram doses usually means just under 60 capsules a day of most over-the-counter supplements. This is the kind of dose that I've taken before to get rid of infections. At the longest, I've used such a dose for a month to clear up quite a serious infection (picked up during travel
).
IMO however, the active ingredient is the Betaine HCL, and addition of pepsin is not necessary, and is a potential risk factor is some individuals. eg: there are some potential contra-indications to esophageal damage with high dose Pepsin + NSAIDS (like aspirin) + pre-existing lower esophageal sphincter dysfunction.
Here, I know Betaine HCl is the main thing that we want to focus on, but I wonder if Pepsin is something to worry about or not.