Will Magnesium Citrate interfere or neutralize the effects of Mirtazapine (Remeron)

[Shellnyce]

Appologies if this question lands in the wrong area.

I'm in the midst of sever insomnia from PFS. I broke down and started taking Remeron so I could function. It has been working well until last night. I went from getting a decent nights sleep (only waking once to pee) to last night I litterally did not get 1 minute of real sleep. I took the Remeron right after taking 400mg of Magnesium Citrate which I am now wondering if that might have neutralized the drug as it is manufacturered with Magnesium. I thought maybe @Helen or one of the other science minds here might have some insight. I usually space supplements and medications out. The only other thing that was different yesterday is that I drank more coffee in the morning than I usually do. Its like I went from having the Rememron be very effect to completely ineffective in 1 night which doesnt seem possible in regards to building a tolerance, etc.... Any insight would be greatly appreciated.

 

[Area-1255]

I don't see why it would. Magnesium is a calming mineral. 'Lotta folks use it along with Melatonin to go to sleep. It helps...

For what its worth - I've used Remeron (45MG) + Magnesium together before and the Mag definitely didn't hinder my Sleep. If anything I got to sleep sooner!

There doesn't seem to be any direct interaction between the two substances either, unless I am missing something.

 

[MNK99]

Mag should help sleep.
Doubt it will hinder Remeron unless it is a calcium/Mg channel blocker or something.

It doesn't stop meth, MDMA, amps. Etc...
But that those are a completely different class of drugs (psych stimulants). Doesn't stop cocaine either. It does lower the peak.

Helped insomnia somewhat. Much more this year. With prescription stimulant use , it helped a bit (not daily use at higher doses).

Remeron is a tetracyclic antidepressant.
I think with serotonin and other effects. I highly doubt Mg cancels it. Maybe ever so slightly but Mg is used to restore dopamine receptors (perhaps). If anything Remeron could make people tired (probably not tired enough in your case).
It could also make people have more energy but definitely Mg will not completely counteract it nor anywhere close to it.

 

[Shellnyce]

I don't see why it would. Magnesium is a calming mineral. 'Lotta folks use it along with Melatonin to go to sleep. It helps...

For what its worth - I've used Remeron (45MG) + Magnesium together before and the Mag definitely didn't hinder my Sleep. If anything I got to sleep sooner!

There doesn't seem to be any direct interaction between the two substances either, unless I am missing something.

Thanks. Like I said I went from good sleep to no sleep in one night. It doesn't make sense. I'm wondering if it was all the extra caffeine I had that morning. I am going to bump the remeron from 7.5 to 15mg and hopefully things improve tonight.

 

[Shellnyce]

Mag should help sleep.
Doubt it will hinder Remeron unless it is a calcium/Mg channel blocker or something.

It doesn't stop meth, MDMA, amps. Etc...
But that those are a completely different class of drugs (psych stimulants). Doesn't stop cocaine either. It does lower the peak.

Helped insomnia somewhat. Much more this year. With prescription stimulant use , it helped a bit (not daily use at higher doses).

Remeron is a tetracyclic antidepressant.
I think with serotonin and other effects. I highly doubt Mg cancels it. Maybe ever so slightly but Mg is used to restore dopamine receptors (perhaps). If anything Remeron could make people tired (probably not tired enough in your case).
It could also make people have more energy but definitely Mg will not completely counteract it nor anywhere close to it.

Thanks. I'm gonna bump the dose tonight and hope I get some sleep. I was tapering everything down and thought my insomnia was improving and then get hit with such a horrible night.

 

[Area-1255]

Thanks. Like I said I went from good sleep to no sleep in one night. It doesn't make sense. I'm wondering if it was all the extra caffeine I had that morning. I am going to bump the remeron from 7.5 to 15mg and hopefully things improve tonight.

15 Mg is the [standard] Minimum dose of Remeron. 7.5mg probably isn't enough to give you really any major benefits.

 

[jacknap]

15 Mg is the [standard] Minimum dose of Remeron. 7.5mg probably isn't enough to give you really any major benefits.

I think remeron also increases serotonin though which can be bad for libido. this guy who crashed 4 months before me from fin now told me he's recovered now and he used remeron. though I've caught him lieing about his recovery before so take with a grain of salt. he's definitely doing way better now though

 

[Shellnyce]

I think remeron also increases serotonin though which can be bad for libido. this guy who crashed 4 months before me from fin now told me he's recovered now and he used remeron. though I've caught him lieing about his recovery before so take with a grain of salt. he's definitely doing way better now though

Recovered from sleep issues or recovered from all the PFS stuff ? I have almost no PFS sides besides head pressure and insomnia. And yes... Remeron def put a dent in my libido. I still wake up with erections but during the day I'm not as stimulated. But if I watch some pron everything works as it should.

 

[Shellnyce]

15 Mg is the [standard] Minimum dose of Remeron. 7.5mg probably isn't enough to give you really any major benefits.

A low dose apparently has more of a sedative effect than a high dose which is counter intuitive. Something to do with activating seratonin but not ephipherine ? ONce you go higher it activates both and cancels out the sedative traits.

 

[Raincoast]

I have been experiencing brutal insomnia and panic and anxiety. I have not slept more than a few hours in the last couple of months. Literally laying awake all night. I have tightness in my chest today. Emotional pain brought this on. Is there anything I can do? Mirtazapine doesn't work, my body pushes past anything sedating. I drift off and then wake with panic and pounding heart. I'm beyond desperate, I'm losing it, can't think clearly anymore. @Helen any ideas?
Things I've tried:
Tryptophan
Calcium & Mag Chloride
U-Dream
Antihistamines
Mirtazapine
Hot shower
CBD oil

Nothing is calming me

 

[Shellnyce]

I have been experiencing brutal insomnia and panic and anxiety. I have not slept more than a few hours in the last couple of months. Literally laying awake all night. I have tightness in my chest today. Emotional pain brought this on. Is there anything I can do? Mirtazapine doesn't work, my body pushes past anything sedating. I drift off and then wake with panic and pounding heart. I'm beyond desperate, I'm losing it, can't think clearly anymore. @Helen any ideas?
Things I've tried:
Tryptophan
Calcium & Mag Chloride
U-Dream
Antihistamines
Mirtazapine
Hot shower
CBD oil

Nothing is calming me

I have seen some talk of Silexan (lavendar extract) which helps. It has very good clinical trial data in germany and people say it acts like a Benzo. But what your describing sounds like you need something a little more powerful. You should really see a doctor ASAP. I found that trying to cure certain things on from the internet is bad. Get in front of a good doc. Treat the symptoms. Once things are under control... go back and decide how to proceed. It sounds like you need Klonopin or Lithium or something for the anxiety.

 

[jacknap]

Recovered from sleep issues or recovered from all the PFS stuff ? I have almost no PFS sides besides head pressure and insomnia. And yes... Remeron def put a dent in my libido. I still wake up with erections but during the day I'm not as stimulated. But if I watch some pron everything works as it should.

yeah my friend who had pfs says he's fully recovered. libido and everything and he's off remeron too. kinda a disservice he hasn't posted a recovery post. i'll ask him to write it up. I think he had pfs for 1.5-2 years? I think upregulating allopregnanonolne is huge because once sleep is fixed it's easy for the body to recover everything else I'd wager. The nights I sleep well my libido is also very close to normal.

 

[Shellnyce]

yeah my friend who had pfs says he's fully recovered. libido and everything and he's off remeron too. kinda a disservice he hasn't posted a recovery post. i'll ask him to write it up. I think he had pfs for 1.5-2 years? I think upregulating allopregnanonolne is huge because once sleep is fixed it's easy for the body to recover everything else I'd wager. The nights I sleep well my libido is also very close to normal.

I'd like to hear more about his story for sure. If my sleep was fixed I would be 90-95% . The sleep battle seems to be gettign harder and harder. The Remeron doesnt seem to really be working any more. I just got a pile of endocrinologist blood work back and there are some interesting things. Low cortisol and low 17-Hydroxyprogesterone . NOt sure what that means but it seems like a marker for something related to my sleep issues. Also my T is at the very bottom of the range.

 

[jacknap]

I'd like to hear more about his story for sure. If my sleep was fixed I would be 90-95% . The sleep battle seems to be gettign harder and harder. The Remeron doesnt seem to really be working any more. I just got a pile of endocrinologist blood work back and there are some interesting things. Low cortisol and low 17-Hydroxyprogesterone . NOt sure what that means but it seems like a marker for something related to my sleep issues. Also my T is at the very bottom of the range.

My total T is above reference range. Free T mid-high still sleep/libido not what it used to be so it's more complicated than T for me