Same question to you bro, did you notice any big difference in the effect of weed before and after accutane? Or was it pretty much the same?
ah OK. But do you enjoy/like the effect of weed like does it make you feel good? This is important.
but in this time that passed a year ago I had an improvement in libido and erections during accutane and some time later I could not have sex because I could not maintain an erection 100% it seemed that I did not feel any stimulus, nowadays I I can have sex practically when I want to, but it's not the same feeling as before, and I depend on a stronger stimulus to stay 100%, before just thinking about sex I was ready haha, I was very " the days with 100% erection, just thinking about sex or looking at some girl I already was 100%, my feelings were others, I was always a cheerful and motivated guy, with a lot of energy too ... that poison ended with me ...
so, the weed distracts me, why I think of suicide and giving up everything all the time, when I smoke weed I get to like a little of some things and think it's cool, but it's little, about 15% what it was before, but still Yes I get some feeling in things,also helps me sleep
when I took accutane I felt very well, self-esteem was 100%, a lot of motivation and excitement in everything, the feelings were very strong, I really liked the feeling of listening to songs that I liked, that strong internal feeling of well-being, I did not I have nothing more of these nowadays, my body does not respond to anything, it seems I'm dead inside ...
Well the fact that weed makes you feel good is a positive. Pretty sure Weed acts predominantly by stimulating your dopamine systems. It would be a good to get a comparison of the effect before and after accutane. Note that accutane can increase dopamine receptor production, so this may explain why things felt really good as accutane makes your dopamine system more sensitive. This is just guess work by the way.
Its also possible that your lack of enjoyment and excitement is linked to you feeling depressed about the sexual side effects etc. I can go from not really enjoying stuff very much to really enjoying music etc. but my sexual side effects don't change.
When you improved sexually from accutane? how much was the change? was it only very small. Did you libido and horniness increase generally, has the change stayed with you or have you lost it again?
Pretty much the same. The reduced sexual responsiveness is pretty much my only side. But it's very noticeable and making me hate my life at times.
I actually had social anxiety before accutane, but i've totally grown over that after accutane because i just stopped caring.
Also, i didn't feel any different on accutane except for the sexual sides
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Right thats interesting. It seems that the sexual side effects of accutane aren't necessarily linked to other mental side effects such as anhedonia, depression etc.
I only asked about the weed because I think its possible that accutane has affected our dopamine systems somehow. However drugs like weed, act largely through the dopamine system so it makes that theory less plausible as you would expect the effect of other dopamine acting drugs to change.
If you want more context on that issue;
I do use a lot of drugs. I smoked weed every day for 5 years and used xtc once a month the years before accutane.
I also get drunk about 3 times a week. After the accutane i started using cocaine weekly, which i did for about 1.5 years before quitting it all together.
So my current status is: Getting drunk about 3 times a week, no other drugs, no smoking.
I'm giving this context because my dopamine system is probably fucked up, and the start of the cocaine use could have hindered my recovery.
I'm trying to figure out how FIN could help reverse accutane's sexual side effects (thats if it even does)? There must be a plausible theory, the guy on acne.org said his doctor said something along the lines of "accutane blocks the androgen receptors, when you take FIN, it competes to block the same androgen receptors which cause the cell to produce more androgen receptors and then they get sensitive again when you stop FIN." - if true, surely you could just take ru486 which also blocks androgen receptors.
Gbol also gave a brief answer to this, which is on the first page of this forum. Again, if FIN helps sort of progesterone sensitivity issues, surely ru486 would help this.
I'm very interested now. Have any post accutane sufferers with sexual side effects, tried using RU486.
There is reason to think that RU486 would lead to increased androgen receptor expression and act as a progestin like FIN.
Gbol also gave a brief answer to this, which is on the first page of this forum. Again, if FIN helps sort of progesterone sensitivity issues, surely ru486 would help this.
I'm very interested now. Have any post accutane sufferers with sexual side effects, tried using RU486.
There is reason to think that RU486 would lead to increased androgen receptor expression and act as a progestin like FIN.
Did you ever try cocaine before accutane? again did the effect change? I know these questions sound stupid but they help build a picture. Did you get the rush/alpha/good feeling from cocaine when you took it after accutane and did you have the sexual side effects whilst using cocaine?
Lots of people take drugs more frequently than that and have normal sex drives. I'm sure it doesn't help but I don't imagine it would have made you much worse or is anything to regret doing.
I'm trying to figure out how FIN could help reverse accutane's sexual side effects (thats if it even does)? There must be a plausible theory, the guy on acne.org said his doctor said something along the lines of "accutane blocks the androgen receptors, when you take FIN, it competes to block the same androgen receptors which cause the cell to produce more androgen receptors and then they get sensitive again when you stop FIN." - if true, surely you could just take ru486 which also blocks androgen receptors.
Gbol also gave a brief answer to this, but I can't find it. I think it was something along the lines of as FIN is a progestin, it
I don't understand why accutane causing increased progesterone levels would lead to increased progesterone receptor expression. Surely there would be a decrease in progesterone expression in response to high levels of progesterone.
Gbol also gave a brief answer to this, but I can't find it. I think it was something along the lines of as FIN is a progestin, it
I don't understand why accutane causing increased progesterone levels would lead to increased progesterone receptor expression. Surely there would be a decrease in progesterone expression in response to high levels of progesterone.
Orion
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I think depending on your body chemistry you can end up with low or high sensitivities, same with PFS/PSSD, seems there could be two post case types. blood tests and hair analysis are probably the best tools to determine.
CrazyPickles
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Regarding the last guy who used Fin to treat his sexual sides (idontknow1993), does anyone know if his symptoms manifested while on Accutane, or after he stopped?
Is this related to the intracellular levels of potassium etc. at the time you take the treatment? I've seen that many of Gbols theories revolve around this. Are there any studies to back this up? I just can't find much research which states that receptors are differentially expressed depending on intracellular mineral levels.
Orion
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You will need to ingauge @gbolduev, he has mentioned that there are not really any studies showing this stuff, but he has tested with people and shown the results that he has posted. I will pm you a doc I have compiled of all gbolduev posts from RPF and here so you can read through.
EDIT: attaching PDF converted to text here(to compress size), cannot do it in PM's
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The only thing i noticed is that before accutane i would always end up extremely horny at the end of the night when i was drunk. Post tane this (almost) never happens.
Unfortunately i never used cocaine before accutane, so i can't compare before and after.
My friends tell me cocaine makes them horny as fuck, but i've never gotten horny on cocaine.
I do sometimes get very horny when drunk, but this usually happens only once in three months.
This gives me hope because that means i haven't turned asexual, and i still have hope it can be fixed in theory.
About the finasteride theory:
I've read a lot less than you guys, but on the ray peat forum some guys speculated that the 5AR-I receptor (which is found in the brain) is down-regulated post accutane.
A decrease in DHT up-regulates these receptors (type I, not type II), which is why finasteride works as a treatment for post accutane victims.
This is based on a study they quoted which found a inverse correlation between 5AR I regulation and DHT and a positive correlation between testosterone and 5AR II.
So more testosterone --> more 5AR-II, less DHT --> more 5AR-I.
This theory also supports the 5AR withdrawal theory (by Mew from propeciahelp). In some guys the DHT reduction leads to over expression of 5AR-I in the brain, causing the receptors to "fry" and become insensitive.
Fair enough, yeah well if the people who say they have recovered are telling the truth, then there is hope. Also a guy on this forum even said his sexual sides improved a lot on some steroids, not a long term solution but apparently helped for some reason. There has to be a fix.
Right I know some people say accutane is a type 1 5-alpha reductase inhibitor. I don't know if it just blocks the enzyme or actually reduces its gene expression though. An important question is whether accutane blocks 5 alpha reductase type 2 as well and we don't know about it yet. When you say causing receptors to "fry" and become insensitive, which receptors are you referring to?
The theory kind of makes sense though I guess.