FINASTERIDE: PFS MECHANISM (detailed)

[Snow1]

If you want to, def try it man. @Rid had great success with it as well, check out this log Rid's Log (return to Pre-PFS State and the final stretch)

Cheers mate, just read the thread sounds positive!

 

[Legna88]

Turmeric (ground)- Iron, Potassium - 100gr

Ginger (ground)- Manganese - 100gr

interesting, so spices/herbs work because of their mineral content... did not know ginger is almost as high in manganese as ground cloves (30mg/100g)

 

[Helen]

Here is a very good explanation. Inhibition of Human Steroid 5β-Reductase (AKR1D1) by Finasteride and Structure of the Enzyme-Inhibitor Complex

Basically finasteride stops its own metabolism. LOL nice freaking drug

If we somehow start up 5 beta, this will metabolize fin out of the body. are they saying fin is still in the body? LOL

 

[HerrFisch]

I was thinking. in the body to make xylitol you need NADPH. I'm wondering if you take xylitol , would this inhibit g6pd a little, I am not sure about this. Just throwing it out there.. this should decrease NADPH, and increase NADP and cause bile to flow. Lower cortisol and aldosterone . this can work exactly like Finasteride. Only without side effects. I remember I heard somewhere they use xylitol against candida. Well that would makes sense. Bile flow kills SIBO

Just an idea. not sure if anyone try this

There is a woman who claims she started to live on xylitol and she is ageless .

Dude she looks like michael jackson. Look at her forehead and the skin when she tries to raise her eyebrows. There is no skin which could fold to wrinkles. Her face looks clamped up.
Plus even though she has pretty little wrinkles, the wrinkles she has look very unnatural. Like the ones at her mouth.
Look at her face from the side at 2:41. That looks like a lot of surgeries to me.
I really doubt she never used botox etc.

She may be looking good for her age, but never natural.

She invested money in her face &body and now tells everybody its because of something she took or did different than others. Big profit

 

[Helen]

Dude she looks like michael jackson. Look at her forehead and the skin when she tries to raise her eyebrows. There is no skin which could fold to wrinkles. Her face looks clamped up.
Plus even though she has pretty little wrinkles, the wrinkles she has look very unnatural. Like the ones at her mouth.
Look at her face from the side at 2:41. That looks like a lot of surgeries to me.
I really doubt she never used botox etc.

She may be looking good for her age, but never natural.

She invested money in her face &body and now tells everybody its because of something she took or did different than others. Big profit

yeah, I noticed it also. Looks like she had plastic surgeries. Scam scam everywhere LOL

 

[joekool]

NADPH and NADPH Oxidase - Functions & Health Effects - Selfhacked

@gbolduev is this the nadph you're referring to?

 

[supernature]

interesting, so spices/herbs work because of their mineral content... did not know ginger is almost as high in manganese as ground cloves (30mg/100g)

...

 

[RebelWithACause]

Here is a very good explanation. Inhibition of Human Steroid 5β-Reductase (AKR1D1) by Finasteride and Structure of the Enzyme-Inhibitor Complex

Basically finasteride stops its own metabolism. LOL nice freaking drug

If we somehow start up 5 beta, this will metabolize fin out of the body. are they saying fin is still in the body? LOL

That's crazy.

 

[MNK99]

I've heard that before, never quite understood what that entails. And it's been speculated that it may still be in the body.
Nice study @gbolduev. What an "anti-health", nonsense of a drug.

 

[Slayo]

Here is a very good explanation. Inhibition of Human Steroid 5β-Reductase (AKR1D1) by Finasteride and Structure of the Enzyme-Inhibitor Complex

Basically finasteride stops its own metabolism. LOL nice freaking drug

If we somehow start up 5 beta, this will metabolize fin out of the body. are they saying fin is still in the body? LOL

Yes in propeciahelp and solvepfs years ago this theory was discussed, we knew about fin stopping its own metabolism

 

[IHateFin]

Yes in propeciahelp and solvepfs years ago this theory was discussed, we knew about fin stopping its own metabolism

I remember hearing too that it stops it's own metabolism. Odd but interesting. I also like how gbold expounded on it a bit further cuz I feel like we know more on it now due to realization that 5beta reductase is what causes us to be receptive to androgens in the first place.
Still seems to be a malfunctioned feedback loop that we are left with, but if we can somehow get 5beta back then everything else should fall in place. Promising stuff

 

[Helen]

Guys if this is the truth and fin does not get metabolized since 5 beta is down. first we can try to increase NADP. I am not sure if they sell it.

Also we can try to lower NADPH at the same time. to allow 5 beta metabolize fin faster.

5 beta's end product is NADPH. so if NADPH is high 5 beta is inhibited. So we need something that lowers NADPH which could be androsterone, or xylitol. Xylitol is made by the NADPH dependant enzyme.

So I am thinking salt loading, xylitol, and NADP ( if you can buy it) and niacin loading.( 7 gram-10 grams a day ) to increase NADP b2 b3 loading.
Basically the goal is to turn down NADPH and ram NADP. until fin is metabolized.

Copper also inhibited g6pd enzyme. which makes NADPH. this is why copper was working for some people. along with magnesium and potassium

If you get back to prefin, you will be losing hair. This is why I rec to you to go and get hair tested and then do all of this according to your metabolism. This way you wont lose any hair and you will get rid of PFS.

 

[Niles]

@gbolduev

Would this work as an NADP source?: beta-Nicotinamide Adenine Dinucleotide phosphate sodium salt hydrate 100 grams | eBay even if so, not sure about dosages and whether it would be cost effective.

 

[IHateFin]

Guys if this is the truth and fin does not get metabolized since 5 beta is down. first we can try to increase NADP. I am not sure if they sell it.

Also we can try to lower NADPH at the same time. to allow 5 beta metabolize fin faster.

5 beta's end product is NADPH. so if NADPH is high 5 beta is inhibited. So we need something that lowers NADPH which could be androsterone, or xylitol. Xylitol is made by the NADPH dependant enzyme.

So I am thinking salt loading, xylitol, and NADP ( if you can buy it) and niacin loading.( 7 gram-10 grams a day ) to increase NADP b2 b3 loading.
Basically the goal is to turn down NADPH and ram NADP. until fin is metabolized.

Copper also inhibited g6pd enzyme. which makes NADPH. this is why copper was working for some people. along with magnesium and potassium

If you get back to prefin, you will be losing hair. This is why I rec to you to go and get hair tested and then do all of this according to your metabolism. This way you wont lose any hair and you will get rid of PFS.

Would combining copper with Randro fair well?
Does estrogen play any roll in 5beta reductase?

 

[IHateFin]

@gbolduev

Would this work as an NADP source?: beta-Nicotinamide Adenine Dinucleotide phosphate sodium salt hydrate 100 grams | eBay even if so, not sure about dosages and whether it would be cost effective.

Why does this seem like exactly what we need?
Nadp - check
Sodium- check
Beta isoform- check

If gbold confirms this increases 5 beta reductase I'll buy it so fast it will make your heads spin. You guys know how I am

 

[tallglass13]

I wish we could gain hair somehow, not just "not lose hair". Plus get good erections. Any way that could be possible? Im guessing the Androsterone will block 5 alpha and NADP and Xylitol will boost 5 Beta, right? So by blocking 5 alpha, that should stop hair loss hopefully.

 

[IHateFin]

I wish we could gain hair somehow, not just "not lose hair". Plus get good erections. Any way that could be possible? Im guessing the Androsterone will block 5 alpha and NADP and Xylitol will boost 5 Beta, right? So by blocking 5 alpha, that should stop hair loss hopefully.

Low dose naltrexone will make you keep your hair too man. It's an elastase inhibitor

 

[IHateFin]

ya know coconut oil reduces 5alpha reductase with the contents of lauric-acid. if one pounded some coconut oil on the reg could this work as well? coconut oil is also said to increase cholesterol utilization and conversion to bile salts and in its self doesnt require bile to digest since a pure saturated fat.

this would be an easy and cheap way of maybe upregulating 5beta reductase. i consume a lot of coconut oil based products, but i dont think i consume enough pure coconut oil to make this happen to any crazy extent.

i will say that some times when i leave the coconut oil in my hair over night i shed more the next day with increase scalp tingles.

there was a study on pigs who consumed coconut oil vs soybean pil and the ones consuming coconut oil got shredded and i never understood why they would get shredded if their dht was being lowered, but if 5beta reductase controls our response to androgens in the first place then maybe thats what was happening to those pigs. unfortunately dht and these enzymes were not tested.

 

[Admiral]

Why does this seem like exactly what we need?
Nadp - check
Sodium- check
Beta isoform- check

If gbold confirms this increases 5 beta reductase I'll buy it so fast it will make your heads spin. You guys know how I am

You might already have. Item isn’t even available anymore.

I hope there are alternatives to NADP as it is inpossible to come by. I’ve googled thoroughly in multiple languages.

 

[IHateFin]

You might already have. Item isn’t even available anymore.

I hope there are alternatives to NADP as it is inpossible to come by. I’ve googled thoroughly in multiple languages.

yeah i bought it. the chem company that listed it on ebay may have it on their site, but i havent checked. im impulsive and nabbed it.
the site that listed it is called chemwise. i have not looked at the site myself yet