RU / "Mifepristone Challenge" Log

[bruschi11]

@jinstewart Read in another thread your rash is completely gone. So happy to hear that you’re not going through the same shit I’m going through. Just had an appointment with my dermatologist today and he has given up. Just can’t understand why my scalp is so inflamed, itchy and Acne. He wants to put me on Accutane. I said no fucking way, LOL. He ended up writing me a script for something to reduce oil production in my skin.

I think you gotta stop with these doctors man they have zero idea what they are doing with you. Medication after medication- they are ruining your life and it hurts me deeply seeing the wrong paths that you’ve been continuously led down.

So you have skin issues, hair issues, libido, body comp, amongst what else? Do you have digestive symptoms, chemical anxiety and depression, fatigue, Brian fog?

I think you need to get a deep picture of what’s going on internally. I know you’ve had a hair test, but what about organic acids testing? I think that could possibly tell you a lot about yourself. Are you in the USA?

 

[Minime]

My goodness yes, I read your thread and experience with RU a few times before deciding to roll the dice myself. It sounds like a real trial there, definitely don't envy you. Sending you my best wishes with it, hope it turns around.

My rash was noticeable on the Monday, NOTICEABLE with red face on Tuesday, BAAD on Wednesday, diminished on Thursday, almost gone Friday, barely visible Saturday, totally gone Sunday. Oily skin though returned shortly after the cycle I think, or maybe towards the end. Sleep was AWESOME when cycle finished, then a few flickers this week. I'm DEFINITELY expecting ups and downs though. Mentally, yes also been ups and downs but the trend of (I'd say) psychological improvement and feeling of wellbeing that's set in is truly significant. Like a REAL blow to the jaw for PFS.

DHT results we're STILL waiting for - I'm hoping that'll mean they're so sky high they've been kicking the machine all week, but I'm assured that's tomorrow. Tiny tiny sexual improvements too, return of very weak occasional morning wood also. But occasionally some libido too, just a little fragment.

Lots of 'character' has come back. Gym has been quite good too, although I'm not getting back again until Friday now. This might sound weird too, but I think I 'felt' low estrogen before (clicking aching joints when lifting/living) but especially from today I'd SWEAR estrogen is 'working' again.

This needs running again. I'm going to see how I feel in a month and run another set of 'pre-bloods' again, just to sanity check beforehand. That one will be 7+ days at 1.1g /day. I might also have found a reliable source of mifepristone powder, which (if this pans out) would mean you'd get a whole cycle done for <$180. I'll keep you folks posted.

Thanks everyone. No huge updates but my quality of life has certainly improved, and PFS just took a BIGGG knock! Let's hope this all sticks and we learn a few things.

Interesting comment regarding estrogen. My estrogen was very high prior to RU. After RU my estrogen levels were in range. Not sure if that’s good or bad. I read high estrogen prevents hair loss.
Glad to hear things are going well for you. Sleepless nights are awful so I’m glad to hear you’re sleeping better as a result of RU. Keep us posted and best of luck to you.

 

[Minime]

I think you gotta stop with these doctors man they have zero idea what they are doing with you. Medication after medication- they are ruining your life and it hurts me deeply seeing the wrong paths that you’ve been continuously led down.

So you have skin issues, hair issues, libido, body comp, amongst what else? Do you have digestive symptoms, chemical anxiety and depression, fatigue, Brian fog?

I think you need to get a deep picture of what’s going on internally. I know you’ve had a hair test, but what about organic acids testing? I think that could possibly tell you a lot about yourself. Are you in the USA?

Digestion is fine at the moment, despite being on an antibiotic for 4 weeks (stopped two weeks ago I believe...felt better while on the antibiotic because I was able to gain weight while on it). Depression...I definitely have that. It’s impossible not to when I look the way I do. Fatigue is unfortunately very high for me...could be part of the depression though too. I have not looked into an organic acid test yet. I will research it. A friend of mine is suggesting Ayurveda but I don’t know much about it. I guess he knows someone who successfully detoxed himself from Accutane by working with an Ayurveda specialist. I may look into that.

 

[5 alpha]

Hey there - I saw the rash pictured on a study once in fact. It's like a low-level acne on the trunk of the body, upper arms and neck and that's it (so far! Lol.) It's totally not that bad, much like acne. Here's an equivalent, but not actually "it":

Also coincides with skin feeling warmer and a little oilier than it's been during PFS. Which I'm feeling kinda good about. Iirc in the same study I read, everybody got over the rash within a couple months.

I was thinking tbh next time I'll run 1g/day for 7 days. But I'm not sure really. If the outcome of this is resetting the HPA axis, I don't think it's possible to 'reset it more' - although it might be doing any amount of magic.

Either way I'll give it AT LEAST 6 weeks before another stab, and I'll find suppliers of powder instead, way cheaper.

Any ideas or thoughts on anything? And yes good lord isn't sleep just BEAUTIFUL again now? Gone is the perpetual "tired but wired" thing and when you wake up, the world just blends back into you during those waking seconds, rather than being dropped back into ANOTHER day of PFS agony.

Where did you source your RU from that you used last? I was with the first group who tried the RU 50MG for three days and got amazing results. I felt like I was going to beat this thing. The results faded. I ran two more trials at 50MG for three days and got little to no results. More recently in January 2019 I purchased RU from the same website we have been getting it from. They screwed me. I paid for 600 MG of RU (three packs of 200MG) and only received one pack of 200MG. So I paid for 600 MG and received 200MG. They would respond to the chat every time I followed up asking about the rest of my order and they would respond by saying well how many abortions are you trying to have because the one kit you received is enough for one abortion. So they were just more or less busting my chops because I was a guy ordering RU haha... Because they did not accept the credit card I wanted to use for the purchase they let me use pay pal. This ended up working in my favor because i reported the transaction to pay pal as a drug transaction that came from oversees. Pal pal has a strict policy against its service being used for prescription drugs purchases oversees. Well the end result was I got even with them which initiated an investigation against them from Pal Pal and Pal Pal refunded me all of my money and I ended up with. 200 MG worth of RU for free in the end. So I totally got even with them.

On a side note I ran one 50 MG at 3 day run and got no results. I broke up the remaining 50 MG in ten MG dosage and also got no results.

I am curious though has anyone else had any trouble sourcing the RU through the regular site ? Also did you ever end up getting your blood work results from when you were on RU?

 

[jinstewart]

Hi @5 alpha - I stuck the link up in the other thread, these folks did accept PayPal and seemed quite decent both orders: https://hackstasis.com/threads/why-we-no-longer-discuss-ella-ru.1618/page-2#post-52722

Okay AT LONG F-ING LAST DHT results whilst on cycle came in: DHT - 1.93nmol/L (1.14-4.13) Low/mid, got higher

Amended the previous results where posted here too. So, DHT got higher for sure but didn't rise as dramatically. Then again, this was the morning of day5/5. Is DHT entirely made from test via 5ar? I guess any increase is good though.

So, a couple of weeks after, here's a little summary.

Improved things:
Sleep - ups and downs but a trend upwards. Sleep is about 80% pre-fin.
Mood - that and 'world immersion' are way better.
Skin - oily now.
Joints - not aching and creaking. Estrogen?
Sexually - okay, tentatively saying this has improved a tiny bit. Masturbation I have done every day (sorry @RebelWithACause and @bruschi11 !) Bruschi will probably especially remember my other log thread when I was breaking down pretty much after a post-masturbation crash but it's pleasurable now and I can definitely handle it on the daily. Erections are only so-so really. Actual, real sex though I had passably (once Friday and once yesterday.) I'm not fully counting that as a drastic change though, but a move in the right direction. Orgasm does no longer crash me! Multiple orgasms a day are very possible. Morning and nocturnal wood are weak, but maybe getting slightly better as time passes. Libido now comes and goes! Random erections are rubbery and weak but happen.
Sour headache - that 'tries' to creep in sometimes but there's some mental iron door in the way of it now.

Less good things:
Digestion isn't great. Have very soft stools, poop twice daily. On that front, Gillian Hamer is on the case. My latest stool test got contaminated so Genova are making me re-test that, so it'll be another three weeks at least before anything comes in. Urgh.

I'm probably hovering around 70-80% pre-fin and honestly if I got my boners back I could live life like this.

Give me a few weeks and we'll do post-bloods. Shortly after that I'll run this again at around 1g/day for 7 days.

 

[Admiral]

One of the most interesting trials to date. Hope things keep improving for you @jinstewart!

Read that you took 800mg's for 5 days straight. How many pills are that?

 

[Admiral]

One of the most interesting trials to date. Hope things keep improving for you @jinstewart!

Read that you took 800mg's for 5 days straight. How many pills are that?

Never mind; that's 4 pills a day, 20 in total. That's about 2500 Euro's. Scheisse.

 

[Helen]

@Admiral 2O pills by 200mg is 16000 rubles , which is 250 bux in here. Таблетки для прерывания беременности, мифолиан, мизопростол, медикаментозный аборт, мифипристон, мифепристон купить в Москве, мифепристон цена, мифипристон цена в аптеке

they say they deliver to other countries from russia. Not sure how good this delivery is, but I bought mife on this site with no problems before.

 

[TubZy]

Or you try RU486 powder on alibaba

 

[Admiral]

@Admiral 2O pills by 200mg is 16000 rubles , which is 250 bux in here. Таблетки для прерывания беременности, мифолиан, мизопростол, медикаментозный аборт, мифипристон, мифепристон купить в Москве, мифепристон цена, мифипристон цена в аптеке

they say they deliver to other countries from russia. Not sure how good this delivery is, but I bought mife on this site with no problems before.

Grazi. I might definitely consider this route in the near future. You just have to help me out with the language though.. :|

 

[Helen]

Grazi. I might definitely consider this route in the near future. You just have to help me out with the language though.. :|

I will, but you can just use translate to english in your browser.

 

[jinstewart]

@Admiral 2O pills by 200mg is 16000 rubles , which is 250 bux in here. Таблетки для прерывания беременности, мифолиан, мизопростол, медикаментозный аборт, мифипристон, мифепристон купить в Москве, мифепристон цена, мифипристон цена в аптеке

they say they deliver to other countries from russia. Not sure how good this delivery is, but I bought mife on this site with no problems before.

Cheers Helen. I'm also messaging them. Got powder supposedly on the way enough for the next big cycle, but I'd certainly prefer something branded.

 

[5 alpha]

jinstewart,

I caught up on your trial. You are a warrior. Your dedication and desire to beat this is outstanding. I have never seen such a well planned and organized trial. The before, during and after blood work is perfect and not to mention you stopped taking everything before you started. This is a clean trial and we need more of this. This really did take some guts. 800 MG of RU for five days!! The entire PFS community owes you for this. I know I am rambling but I am so pumped about this and admire you for doing it.

So in summary I wanted to go over a couple of things to make sure I am following and keeping track of what needs to be kept track of:

Your total T, free T and DHT were more or less in the normal range prior to starting your trial. About half way through your trial your total T, free T and DHT increased by not all that much but enough to put your free T and total T slightly over the top of your labs reference range. Your LH and FSH were on the low side before your trial and remained on the lowish side half way through your trial. So really nothing significant with changes to your total T, free T, DHT, LH and FSH during trial. However, your progesterone and cortisol which were already on the high side increased significantly during your trial. Before trying to chime in on any possible conclusions that can be made thus far I first wanted to make sure that I am correct with everything I stated in my summary.

What is your current plan on the post labs? How are you feeling now?

honestly man this is fucking awesome

cheers

 

[Ergogenic Health]

jinstewart,

I caught up on your trial. You are a warrior. Your dedication and desire to beat this is outstanding. I have never seen such a well planned and organized trial. The before, during and after blood work is perfect and not to mention you stopped taking everything before you started. This is a clean trial and we need more of this. This really did take some guts. 800 MG of RU for five days!! The entire PFS community owes you for this. I know I am rambling but I am so pumped about this and admire you for doing it.

So in summary I wanted to go over a couple of things to make sure I am following and keeping track of what needs to be kept track of:

Your total T, free T and DHT were more or less in the normal range prior to starting your trial. About half way through your trial your total T, free T and DHT increased by not all that much but enough to put your free T and total T slightly over the top of your labs reference range. Your LH and FSH were on the low side before your trial and remained on the lowish side half way through your trial. So really nothing significant with changes to your total T, free T, DHT, LH and FSH during trial. However, your progesterone and cortisol which were already on the high side increased significantly during your trial. Before trying to chime in on any possible conclusions that can be made thus far I first wanted to make sure that I am correct with everything I stated in my summary.

What is your current plan on the post labs? How are you feeling now?

honestly man this is fucking awesome

cheers

Can I just say you have legit the best username I have ever read! haha!

 

[5 alpha]

Can I just say you have legit the best username I have ever read! haha!

haha... It kinda of evolved. I started with 5 alpha victim and went from PH to solve PFS to SS before ending up at ray peat which brought me here. When I was at SS the guys on that forum were busting my chops over "coming across like I am a victim". So I guess it kinda stuck with me and when it became time to make my account here I just deleted the victim and I was like well that actually kinda looks cool as well so I am running with it.

 

[5 alpha]

Cheers Helen. I'm also messaging them. Got powder supposedly on the way enough for the next big cycle, but I'd certainly prefer something branded.

I am taking a look at the options to source RU that have been discussed:

 

[MNK99]

I used 24medline dot com or similar (medside perhaps)... whatever it's called. And goldpharma for ella. I think ali baba could work too.

 

[jinstewart]

Hi guys - sorry work is insane at the moment. Truly insane. I'll update when I can. In short, ups and downs and want to run 7 days at 1-1.2g asap.

I'll get back.

 

[Helen]

Hi guys - sorry work is insane at the moment. Truly insane. I'll update when I can. In short, ups and downs and want to run 7 days at 1-1.2g asap.

I'll get back.

please don't run anything. let it settle.

 

[jinstewart]

please don't run anything. let it settle.

OK roger that, I'll stay clean for a bit. Post-bloods I'll probably try and run next week, think that's enough time for those?

Sorry all, work really is frantic. I'm actually coping with the intense stress a little better than I normally would be but won't be near the gym etc and diet might slide a touch.

Apologies, I'll update properly when I can.