ZINC FINGER THEORY DISCUSSION for PFS - 2 cases

[Canari]

I wouldn’t consider myself even close to fixed from anything if something like occasionally drinking wine messed everything up.

I’m reporting here that for the first time in over a decade, I’m able to drink wine and not have the flushed red face. Winning, not losing. Wasn’t even a goal, just a bonus.

Also not the slightest bit interested in being pedantic about my diet. I eat ok; sometimes great, sometimes not. The minerals/aminos do things regardless of my diet.

That is super great indeed, and that is why I wanted to know if this old reaction you had was about Acetic acid transformation in the body, and if it was linked to all what gbol said about vinegar being bad... Just to understand the link with the aminos and minerals you take. I do not remember all about the pathways of wine and vinegar in the body, but this is a concern for me, because I was intoxicated by ethanol as a fetus. I am limited in alcool consuming and think it was good for me to stop apple vinegar.

So, to know more would help me...

 

[Rid]

Wanted to also add that since I was a teen I had a tendency toward flushing/blushing cheeks and general redness on my face. Not a fin related thing.

Always flush when drinking red wine. When I dabbled with testosterone I was red face all the time. Worst when exercising or alcohol.

Drank heaps over the last weekend, got horny as fk, didn’t flush once. Histidine + copper or the ghk-cu (not sure)...this stuff doing stuff.

exactly the same here... I get especially red when I binge or eat a lot of carbs, I've noticed that my redness has come back with my libido (maybe just test rising to baseline?) and my oilyness is directly related to it.

Hist + cyst might be helping that, but the biggest thing for me is control of my diet, staying away from carbs, alcohol and especially binging.

 

[B_D_Acc]

Hi there,

Is anyone able to give a brief overview of how cortisol insensitivity caused by a lack of/desensitized zinc finger (glucocorticoid receptor) could cause the sexual side effects of PFS? I sort of understand the theory and find it really interesting as there are reasons to believe that accutane may also disrupt glucocorticoid receptor function (zinc finger). But I'm struggling to find a link between this and the sexual side effects.

I don't understand how the Zinc Finger works fully but it's a protein substructure that's in loads of transcription factors, so errors could mean over or under transcription. What I do know is that as soon as there's elevated progesterone (from elevated cortisol or whatever) sexual sides can kick in. Androgen/oestrogen signalling imbalance too much either = sexual sides. Too much progesterone = sexual sides. Don't know about too little progesterone but wouldn't be surprised if also = sexual sides.

 

[Slayo]

I don't understand how the Zinc Finger works fully but it's a protein substructure that's in loads of transcription factors, so errors could mean over or under transcription. What I do know is that as soon as there's elevated progesterone (from elevated cortisol or whatever) sexual sides can kick in. Androgen/oestrogen signalling imbalance too much either = sexual sides. Too much progesterone = sexual sides. Don't know about too little progesterone but wouldn't be surprised if also = sexual sides.

But what about people that got penis shrinklage, fibrosis, soft gland during erection, loss of soft tissue around the penis almost overnight, how is zinc finger able to explain them

 

[B_D_Acc]

But what about people that got penis shrinklage, fibrosis, soft gland during erection, loss of soft tissue around the penis almost overnight, how is zinc finger able to explain them

No idea bro

 

[Ghost]

But what about people that got penis shrinklage, fibrosis, soft gland during erection, loss of soft tissue around the penis almost overnight, how is zinc finger able to explain them

I took lexapro for 4 days only, and have fibrosis. How I see it, we're in a big mess here. First of all, the SSRI increased my 5-HT levels A LOT. This can increase ROS and that could lead to fibrosis. Fibrosis in the glans penis could lead to soft glans. I've never heard of anyone with PSSD curing their soft glans, so I think that might be fibrosis. Additionally, somewhere along the line I fucked up my pelvic floor. This can lead to sensitivity issues, erection problems, soft glans, and lack of blood flow. Again...Fibrosis is a possible result. I don't think that the fibrosis came overnight, but that it's secondary like I mention above. At this point, I probably have:

A PSSD Problem
A Fibrosis Problem
A Pelvic Floor Blood Flow Problem
A Pelvic Floor Nerve Problem
A Developed Sex Anxiety Problem

So treating "PSSD" is only part of the equation for me. If I really want to get to the bottom of all this, I need to fix a lot of things, one step at a time. It's project and not just a simple solution of one hormone IMO. My opinion on this has changed a lot in the past few months since I learned of my fibrosis, and started reading a lot of threads from people with hard/flaccid, soft glans, and pelvic floor dysfunction. A hormone or a treatment might do a large chunk of getting us back to normal, but there will be other parts that will need to be completed, and I personally know I'll need years of PTSD therapy after all this.

 

[Shanks]

I took lexapro for 4 days only, and have fibrosis. How I see it, we're in a big mess here. First of all, the SSRI increased my 5-HT levels A LOT. This can increase ROS and that could lead to fibrosis. Fibrosis in the glans penis could lead to soft glans. I've never heard of anyone with PSSD curing their soft glans, so I think that might be fibrosis. Additionally, somewhere along the line I fucked up my pelvic floor. This can lead to sensitivity issues, erection problems, soft glans, and lack of blood flow. Again...Fibrosis is a possible result. I don't think that the fibrosis came overnight, but that it's secondary like I mention above. At this point, I probably have:

A PSSD Problem
A Fibrosis Problem
A Pelvic Floor Blood Flow Problem
A Pelvic Floor Nerve Problem
A Developed Sex Anxiety Problem

So treating "PSSD" is only part of the equation for me. If I really want to get to the bottom of all this, I need to fix a lot of things, one step at a time. It's project and not just a simple solution of one hormone IMO. My opinion on this has changed a lot in the past few months since I learned of my fibrosis, and started reading a lot of threads from people with hard/flaccid, soft glans, and pelvic floor dysfunction. A hormone or a treatment might do a large chunk of getting us back to normal, but there will be other parts that will need to be completed, and I personally know I'll need years of PTSD therapy after all this.

I'm on the same train..this is so depressing..jezz

 

[Slayo]

for me it happened almost overnight, i developed extreme pain in the penis and then all those things happened, i think it took no more than 3 days, i'm very severe in those issues, i think all this traumatized me too

 

[wuf]

for me it happened almost overnight, i developed extreme pain in the penis and then all those things happened, i think it took no more than 3 days, i'm very severe in those issues, i think all this traumatized me too

Guys, I know it is terrible.
I have been there.
My dick was destroied, I had plaques and scares all over.. doctor diagnosed them...and it was hurting everytime I was trying to get an erection (If I ever could)... time will repair tissues.
My dick is perfectly fine now.

 

[Helen]

I took lexapro for 4 days only, and have fibrosis. How I see it, we're in a big mess here. First of all, the SSRI increased my 5-HT levels A LOT. This can increase ROS and that could lead to fibrosis. Fibrosis in the glans penis could lead to soft glans. I've never heard of anyone with PSSD curing their soft glans, so I think that might be fibrosis. Additionally, somewhere along the line I fucked up my pelvic floor. This can lead to sensitivity issues, erection problems, soft glans, and lack of blood flow. Again...Fibrosis is a possible result. I don't think that the fibrosis came overnight, but that it's secondary like I mention above. At this point, I probably have:

A PSSD Problem
A Fibrosis Problem
A Pelvic Floor Blood Flow Problem
A Pelvic Floor Nerve Problem
A Developed Sex Anxiety Problem

So treating "PSSD" is only part of the equation for me. If I really want to get to the bottom of all this, I need to fix a lot of things, one step at a time. It's project and not just a simple solution of one hormone IMO. My opinion on this has changed a lot in the past few months since I learned of my fibrosis, and started reading a lot of threads from people with hard/flaccid, soft glans, and pelvic floor dysfunction. A hormone or a treatment might do a large chunk of getting us back to normal, but there will be other parts that will need to be completed, and I personally know I'll need years of PTSD therapy after all this.

I think this is what might be happening in PSSD.

You take SSRI, this increases serotonin, serotonin increases NADPH oxidase. this creates tons of ROS. this is why to increase serotonin you need to increase thyroid and metabolism and not take SSRIs. In slow metabolism there is no ceruloplasmin and low serotonin. Doctors give people SSRIs which is ridiculous forcing serotonin in the wrong body chemistry. Serotonin rises with potassium. and thyroid. And this causes ACTH release. which increases cortisol release in FAST metabolism. People that take SSRI in slow metabolism should never take them they should just increase the metabolism. And if you force serotonin in slow metabolism unfortunately metabolism goes even lower since serotonin will increase ACTH and this will increase cortisol and cortisol willl be getting rid of potassium IN SLOW METABOLISM which should never be the case., NADPH oxidase is activated by cortisol , and this causes ROS, but ceruloplasmin is not there since ceruloplasmin goes up only in fast metabolism and you forced cortisol in the slow oxidation with SSRI. Cortisol should be up only if you have tons of potassium in the cell and fast metabolism. . If you would have lifted metabolism , then this metabolism lift would have increased NADPH oxidase but at the same time would increase ceruloplasmin and the extra ROS would have been blocked by SODS But copper cant rise in the cell with low potassium which you caused with SSRI.

This is why feeding thyroid with copper deficiency is VERY VERY BAD. since ROS will be unopposed. And in copper deficiency you get high RT3.

So end effect of taking SSRI in slow metabolism is copper loss and potassium loss at the same time. Since serotonin activated ACTH which increased cortisol and this cortisol lost all your potassium. Thus you have high progesterone .

This is why it is so tricky, metabolism is already low so when you feed copper you feel bad, and if you feed potassium you get more ROS since raising metabolism creates ROS.

This is why you need to feed copper and potassium in a certain manner, copper always should come with electrolytes and associated aminos.



Fibrosis will be gone on its own. if you lower g6pd and using GHK-CU will totally reverse it.

Bioheal - GHK and DNA: Reverse Aging with GHK - Dr. Loren Pickart's Information for Extra Sensitive Skin Issues | NEW Book Now Available: Reverse Skin Aging | Rosacea



GHK-Cu increases decorin – an antioxidant, anti-inflammatory and anti-scarring protein, preventing skin fibrosis.


Copper is what lowers enzyme G6PD and increases insulin.

Numbness that people are experiencing after SSRI, is from Gaba blocking NDMA signaling, Since from NDMA you get supersensitivity. People even have a disease like that-- tactile supersensitivity .

 

[wuf]

I think this is what might be happening in PSSD.

You take SSRI, this increases serotonin, serotonin increases NADPH oxidase. this creates tons of ROS. this is why to increase serotonin you need to increase thyroid and metabolism and not take SSRIs. In slow metabolism there is no ceruloplasmin and low serotonin. Doctors give people SSRIs which is ridiculous forcing serotonin in the wrong body chemistry. Serotonin rises with potassium. and thyroid. And this causes ACTH release. which increases cortisol release in FAST metabolism. People that take SSRI in slow metabolism should never take them they should just increase the metabolism. And if you force serotonin in slow metabolism unfortunately metabolism goes even lower since serotonin will increase ACTH and this will increase cortisol and cortisol willl be getting rid of potassium IN SLOW METABOLISM which should never be the case., NADPH oxidase is activated by cortisol , and this causes ROS, but ceruloplasmin is not there since ceruloplasmin goes up only in fast metabolism and you forced cortisol in the slow oxidation with SSRI. Cortisol should be up only if you have tons of potassium in the cell and fast metabolism. . If you would have lifted metabolism , then this metabolism lift would have increased NADPH oxidase but at the same time would increase ceruloplasmin and the extra ROS would have been blocked by SODS But copper cant rise in the cell with low potassium which you caused with SSRI.

This is why feeding thyroid with copper deficiency is VERY VERY BAD. since ROS will be unopposed. And in copper deficiency you get high RT3.

So end effect of taking SSRI in slow metabolism is copper loss and potassium loss at the same time. Since serotonin activated ACTH which increased cortisol and this cortisol lost all your potassium. Thus you have high progesterone .

This is why it is so tricky, metabolism is already low so when you feed copper you feel bad, and if you feed potassium you get more ROS since raising metabolism creates ROS.

This is why you need to feed copper and potassium in a certain manner, copper always should come with electrolytes and associated aminos.



Fibrosis will be gone on its own. if you lower g6pd and using GHK-CU will totally reverse it.

Bioheal - GHK and DNA: Reverse Aging with GHK - Dr. Loren Pickart's Information for Extra Sensitive Skin Issues | NEW Book Now Available: Reverse Skin Aging | Rosacea



GHK-Cu increases decorin – an antioxidant, anti-inflammatory and anti-scarring protein, preventing skin fibrosis.


Copper is what lowers enzyme G6PD and increases insulin.

Numbness that people are experiencing after SSRI, is from Gaba blocking NDMA signaling, Since from NDMA you get supersensitivity. People even have a disease like that-- tactile supersensitivity .

I am always surprised how you do have always so detailed replies about this stuff.
How is that possible you know all this siht when even no doctor, researcher do?

 

[jaa]

Has anyone used GHK-cu? Where do you source it? How do you administer it?

 

[Steve]

I think this is what might be happening in PSSD.

You take SSRI, this increases serotonin, serotonin increases NADPH oxidase. this creates tons of ROS. this is why to increase serotonin you need to increase thyroid and metabolism and not take SSRIs. In slow metabolism there is no ceruloplasmin and low serotonin. Doctors give people SSRIs which is ridiculous forcing serotonin in the wrong body chemistry. Serotonin rises with potassium. and thyroid. And this causes ACTH release. which increases cortisol release in FAST metabolism. People that take SSRI in slow metabolism should never take them they should just increase the metabolism. And if you force serotonin in slow metabolism unfortunately metabolism goes even lower since serotonin will increase ACTH and this will increase cortisol and cortisol willl be getting rid of potassium IN SLOW METABOLISM which should never be the case., NADPH oxidase is activated by cortisol , and this causes ROS, but ceruloplasmin is not there since ceruloplasmin goes up only in fast metabolism and you forced cortisol in the slow oxidation with SSRI. Cortisol should be up only if you have tons of potassium in the cell and fast metabolism. . If you would have lifted metabolism , then this metabolism lift would have increased NADPH oxidase but at the same time would increase ceruloplasmin and the extra ROS would have been blocked by SODS But copper cant rise in the cell with low potassium which you caused with SSRI.

This is why feeding thyroid with copper deficiency is VERY VERY BAD. since ROS will be unopposed. And in copper deficiency you get high RT3.

So end effect of taking SSRI in slow metabolism is copper loss and potassium loss at the same time. Since serotonin activated ACTH which increased cortisol and this cortisol lost all your potassium. Thus you have high progesterone .

This is why it is so tricky, metabolism is already low so when you feed copper you feel bad, and if you feed potassium you get more ROS since raising metabolism creates ROS.

This is why you need to feed copper and potassium in a certain manner, copper always should come with electrolytes and associated aminos.



Fibrosis will be gone on its own. if you lower g6pd and using GHK-CU will totally reverse it.

Bioheal - GHK and DNA: Reverse Aging with GHK - Dr. Loren Pickart's Information for Extra Sensitive Skin Issues | NEW Book Now Available: Reverse Skin Aging | Rosacea



GHK-Cu increases decorin – an antioxidant, anti-inflammatory and anti-scarring protein, preventing skin fibrosis.


Copper is what lowers enzyme G6PD and increases insulin.

Numbness that people are experiencing after SSRI, is from Gaba blocking NDMA signaling, Since from NDMA you get supersensitivity. People even have a disease like that-- tactile supersensitivity .

So for pssd, we should take copper, potassium, electrolytes and aminos.

What electrolytes and aminos should that be?

And for potassium, is it potassium chloride?

 

[bruschi11]

I am always surprised how you do have always so detailed replies about this stuff.
How is that possible you know all this siht when even no doctor, researcher do?

It’s molecular biology man. That is all.

 

[wuf]

It’s molecular biology man. That is all.

Oh cool, nice to have an answer in my mind now. Thanks!

 

[TubZy]

Has anyone used GHK-cu? Where do you source it? How do you administer it?

GHK-Cu: Hairloss, PFS, COPD, Fibromalgia Discussion

 

[Shadow]

I took lexapro for 4 days only, and have fibrosis. How I see it, we're in a big mess here. First of all, the SSRI increased my 5-HT levels A LOT. This can increase ROS and that could lead to fibrosis. Fibrosis in the glans penis could lead to soft glans. I've never heard of anyone with PSSD curing their soft glans, so I think that might be fibrosis. Additionally, somewhere along the line I fucked up my pelvic floor. This can lead to sensitivity issues, erection problems, soft glans, and lack of blood flow. Again...Fibrosis is a possible result. I don't think that the fibrosis came overnight, but that it's secondary like I mention above. At this point, I probably have:

A PSSD Problem
A Fibrosis Problem
A Pelvic Floor Blood Flow Problem
A Pelvic Floor Nerve Problem
A Developed Sex Anxiety Problem

So treating "PSSD" is only part of the equation for me. If I really want to get to the bottom of all this, I need to fix a lot of things, one step at a time. It's project and not just a simple solution of one hormone IMO. My opinion on this has changed a lot in the past few months since I learned of my fibrosis, and started reading a lot of threads from people with hard/flaccid, soft glans, and pelvic floor dysfunction. A hormone or a treatment might do a large chunk of getting us back to normal, but there will be other parts that will need to be completed, and I personally know I'll need years of PTSD therapy after all this.

I think that Bigmum from PSSDForum reversed his soft glans after a couple of months(4 if Im right) on cdsnuts protocol.

 

[Canari]

This is why you need to feed copper and potassium in a certain manner, copper always should come with electrolytes and associated aminos.

That makes sense, I have high calcium, fibrosis, low copper low K, and my inner bell said no for taking copper as a lonely supp.
Why I got worse only from taking natural progesterone then?

My issues with insuline were there BEFORE, I lack it, as my blood sugar is high.
Can insuline be one pre-requisite for fibrosis problems?

So for pssd, we should take copper, potassium, electrolytes and aminos.
What electrolytes and aminos should that be?
And for potassium, is it potassium chloride?

I agree we need to change the theory of molecular biology into practical precision.

 

[Steve]

That makes sense, I have high calcium, fibrosis, low copper low K, and my inner bell said no for taking copper as a lonely supp.
Why I got worse only from taking natural progesterone then?

My issues with insuline were there BEFORE, I lack it, as my blood sugar is high.
Can insuline be one pre-requisite for fibrosis problems?


I agree we need to change the theory of molecular biology into practical precision.

Correct. We need protocols and results with exactly what to take with dosages listed. Hopefully we will get this eventually.

 

[Ghost]

I think this is what might be happening in PSSD.

You take SSRI, this increases serotonin, serotonin increases NADPH oxidase. this creates tons of ROS. this is why to increase serotonin you need to increase thyroid and metabolism and not take SSRIs. In slow metabolism there is no ceruloplasmin and low serotonin. Doctors give people SSRIs which is ridiculous forcing serotonin in the wrong body chemistry. Serotonin rises with potassium. and thyroid. And this causes ACTH release. which increases cortisol release in FAST metabolism. People that take SSRI in slow metabolism should never take them they should just increase the metabolism. And if you force serotonin in slow metabolism unfortunately metabolism goes even lower since serotonin will increase ACTH and this will increase cortisol and cortisol willl be getting rid of potassium IN SLOW METABOLISM which should never be the case., NADPH oxidase is activated by cortisol , and this causes ROS, but ceruloplasmin is not there since ceruloplasmin goes up only in fast metabolism and you forced cortisol in the slow oxidation with SSRI. Cortisol should be up only if you have tons of potassium in the cell and fast metabolism. . If you would have lifted metabolism , then this metabolism lift would have increased NADPH oxidase but at the same time would increase ceruloplasmin and the extra ROS would have been blocked by SODS But copper cant rise in the cell with low potassium which you caused with SSRI.

This is why feeding thyroid with copper deficiency is VERY VERY BAD. since ROS will be unopposed. And in copper deficiency you get high RT3.

So end effect of taking SSRI in slow metabolism is copper loss and potassium loss at the same time. Since serotonin activated ACTH which increased cortisol and this cortisol lost all your potassium. Thus you have high progesterone .

This is why it is so tricky, metabolism is already low so when you feed copper you feel bad, and if you feed potassium you get more ROS since raising metabolism creates ROS.

This is why you need to feed copper and potassium in a certain manner, copper always should come with electrolytes and associated aminos.



Fibrosis will be gone on its own. if you lower g6pd and using GHK-CU will totally reverse it.

Bioheal - GHK and DNA: Reverse Aging with GHK - Dr. Loren Pickart's Information for Extra Sensitive Skin Issues | NEW Book Now Available: Reverse Skin Aging | Rosacea



GHK-Cu increases decorin – an antioxidant, anti-inflammatory and anti-scarring protein, preventing skin fibrosis.


Copper is what lowers enzyme G6PD and increases insulin.

Numbness that people are experiencing after SSRI, is from Gaba blocking NDMA signaling, Since from NDMA you get supersensitivity. People even have a disease like that-- tactile supersensitivity .

Interesting Theory. Gives a method of ^ Prog, or actually, a method of tanking K+ and Copper, which could be linked to Prog. After we can link this to Prog, we can link it to SERT, and therefore to a mechanism that keeps 5-HT at high levels even after the drug is removed.

The one thing I'm not sure of is the GABA blocking. I've taken various GABA supplements and Ativan while seeing no change in numbness. If you're suggesting that GABA is raised, then wouldn't it also be inhibitory or 5-HT firing?