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Yes, there is an initial disruption. In the first post, I tried to hypothesize what exactly is impaired in us and how it might happen. In principle, for those who are interested, we can discuss other pathways, using how finasteride works as a starting point. I assume that by "regulation" you...

Try to bind toxins. Coal, for example Magnesium inhibits glutamate, which lowers norepinephrine, this lowers the heart rate. My guess is that norepinephrine (or adrenaline) rises in response to histamine. And the histamine problem is probably in the gut - low dao, or inflammation (sibo). So...

Thank you for the answer and that quote. I have already thought about something similar, but in my case, it's not as he describes. He only described one of the possibilities. My crash didn't happen after discontinuation, the crash occurred during the intake itself, so considering receptor...

I apologize for the late reply, for some reason, I wasn't receiving notifications and didn't see your post earlier. I think the issue isn't that TEI isn't working, it's more likely that trying to supply minerals through it is pointless when we have serious gastrointestinal problems. All these...

https://pubmed.ncbi.nlm.nih.gov/32702725/ It seemed interesting to me, even if it's not new information. They found a way and examined in minute detail how the 5ar enzyme is structured and how finasteride acts on it. As I understood from the article, two important amino acids work in the...

When bile is conjugated at the final stage, either glycine or taurine is used, and some people have a problem with glycine, but not with taurine. I thought that might be the case for this person. It's just strange that the person's bile doesn't respond to TUDCA at all. Perhaps the issue is with...

Hi, in general, everything is fine, how are you?)

Maybe you have a problem with bile cofactors, or a problem with glycine, not taurine?

I don't know, I haven't heard that taurine somehow binds copper strongly. Perhaps through indirect pathways, through antioxidants, for example. I'm not sure that the effect of taurine has anything to do with copper.

I think that due to impaired methylation, we have problems with the distribution of cysteine. It likely doesn't go into producing taurine and is probably all diverted to glutathione. Bile doesn't conjugate normally. Taurine is also an agonist of GABA-A, and precisely of those sub-receptors that...

If the improvement occurs towards evening and improves at night, I'm guessing it's just cortisol dropping

Yes, for example, in response to inflammation, high cortisol can remove testosterone so that it doesn't get in the way. But it's not a fact that you have that, I'm just guessing. It's hard to really know if NADPH is high or low. If it's high, in theory you should be getting worse from b1.

Yes, there is, I hadn't noticed. It's not necessarily high NADPH. You have low testosterone and it's not clear what your cortisol is, I didn't see it on the labs. SHBG probably binds your test and possibly DHT (it's not on the labs either). But it's also possible that high cortisol is...

Hi man) Did you find out what kind of infection it was? Could it be a reactivation of something old? Maybe starvation was elevating your glucocorticoid receptor. Cortisol regulates the th1/th2. If it's low or GR doesn't bind to it normally, regulation goes down. You don't have any hormone...

I wanted to read your journal, but you've restricted it in your profile. Can you provide a link to it?

It's okay, bro. I described it all to make it clear why I think PFS is key here. I understand a lot of the mechanisms and basically know what I'm dealing with. The problem with hypersensitivity is no confidence in the theory. I haven't been able to have any effect on it from a practical...

Thank you for your answer and trying to help. Looks like there will be a lot of text again). I want to add that I use a translator and there may be mistakes in the text, so it's not my illiteracy. That's right, it's not only PFS, it's receptor dysregulation, but finasteride is the basis. Let...

No problem man)

Hi. Yeah, you're right, I screwed up before that. I'll try to describe the chain of events, just to give you a general idea. Initially, where it started. Tonsillitis + antibiotics -> chronic tonsillitis, pharyngitis, enlarged cervical lymph nodes and POIS. In POIS, in addition to the typical...

That's interesting, thank you. I've heard it can enlarge the liver and spleen. And can you please tell me what symptoms you've been experiencing personally?