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PSSD is possible zinc toxicity( or copper in some cases may be more for PFS) mechanism goes like this. and in this case, ZINC increases GABA B. that is ALL. zinc blocks gaba a , this increases glutamate to gaba conversion. so total GABA level goes up. this total GABA level acts on GABA...

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PFS could be an imbalances of arachidonic acid. and CB1 receptor. and phospholipase. people need to test their FFAs and supplement and see all their symptoms go away. some need to get rid of sibo, to stop activation of phospholipase. Some folks got psoriasis. in PFS...

thought this was interesting. check out the composition. https://www.cure4herpes.com/

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As we saw from bloods tests of over 10 people with PFS, all of them had the same things going on Sam-e low, and SAH high. this ratio can be impaired by 2 things. 1) GNMT enzyme which converts glycine into sarcosine. takes Sam-e makes SAH. 2)PEMT enzyme which converts...

Some people felt better on this. @joekool @Ocguy As I mentioned, for slow oxidizers high calcium people. I think gaba overexpression might be causing a problem. other gaba a inhibitors are clarithromycin and other microlides. Clarithromycin in GABA-related Hypersomnolence: A...

I wonder if people did the test for this in their stool and what results they got. E coli if high can causes choline deficiency. and creating TMAO which could transfer NAFLD into NASH. and if low it can cause vitamin K2 deficiency , folate, b12 def and choline intolerance may be...

As we look at dutasteride and finasteride cases, we see that 70% or more of people come off those and experience no side effects, no PFS . this tells us that there is some condition which has to be met to crash from those. And that condition might be a fatty liver.

I wonder what cholesterol levels you guys have.

Changes in brain testosterone and allopregnanolone biosynthesis elicit aggressive behavior this seems exactly what finasteride does. this is why @Cdsnuts steered people away from TRT and rec'd LH and FSH increasing herbs. big difference to increase LH with herbs and decrease LH...

Just wanted to mention this. As the symptoms are identical to PFS. Some people cycled this and got PFS like condition which is lasting them years now. Gents93 story - Post Aromatase Inhibitor Syndrome Lowe2sucks post anastrozole (aromatase inhibitor) "syndrome" PAS Another possible...

As you know we found very high levels of fungus malassezia restricta in POIS victims and some PFS. some people got cured from antifungals. Here is tribulus In vitro and in vivo antifungal activities of the eight steroid saponins from Tribulus terrestris L. with potent activity against...

If GABA A overexpressed , just like after surgeries, it gets stuck like that, it causes CFS after surgery, I understand that this is not a cure, but can someone try to block GABA A with artemisia ( wormwood) and see if this clears PFS. This is just to understand what is stopping...

As we know , many people slow oxidizers have very low ACTH. and cortisol levels And some of them tried to take thyroid but cortisol stays low giving tons of symptoms. thus they have to take thyroid with cortisol and testosterone as Justquitdut did which basically solves PFS. (...

Guys, if you look at Melcangi study and Wuf's blood tests and CSF values. You will clearly see, that DHT is zero in CSF. It is very low and testosterone is high in CSF Testosterone is not being converted into DHT in the brain. It is very clear. And since testosterone is already high there body...

Thought I start this thread, since a lot of people are experimenting with this on PSSD forum, and we have more and more studies for both PSSD and PFS about this. Here I found an interesting one. Does increased expression of glucocorticoid receptor support application of antagonists to...

GABAA Receptor Theory of Perioperative Neurocognitive Disorders | Anesthesiology | ASA Publications they suggest to use A-2 agonist here to reverese gaba a overexpression. interesting as I suggested a-1 antagonist in another thread. Since a-1 and a-2 go opposite of each other...

https://www.onlinelibrary.wiley.com/doi/abs/10.1002/ddr.430030502 A pilot study of the pharmacodynamic impact of SSRI drug selection and beta-1 receptor genotype (ADRB1) on cardiac vital signs in depressed patient... - PubMed - NCBI Beta-1 adrenergic receptor - Wikipedia...

I would outine 3 possibilities here, which we can test. A) The suggested reason for PFS is the discrepancy between androgens levels and α1a-adrenoceptor levels. When people get castrated or androgen deprived. a1a- andrenoceptor levels goes down. It is the thing which...