I would outine 3 possibilities here, which we can test.
A) The suggested reason for PFS is the discrepancy between androgens levels and α1a-adrenoceptor levels.
When people get castrated or androgen deprived. a1a- andrenoceptor levels goes down. It is the thing which constricts the prostate . Androgens vasodialate prostate. by releasing nitric oxide.
So when people take away androgens, A1A- receptors have to downregulate so keep prostate less constricted.
then when androgens go back up, there is no A1A -receptors to constrict it enough, and the body had to 1) stop androgen reception which is already TOO MUCH.
2) has to increase levels of NORADRENALINE since it activate sA1A receptors and since receptors are weak, noradrenaline goes up, to increase its action. Which lowers dopamine.
3) has to bind DHT with SHBG to stop vasodilation, that is why DHT does not work, the more you take it, the more body will be lowering dopamine to get to NORADRENALINE.
4) has to break down NADPH via NADPH oxidase, for that it RAISES CALCIUM, this is why people were helped by vitamin D. since vitamin D 1.25D downregulates androgen receptor transcription.
So calcium activation is not a mistake I guess. the body actually doing it to increase NOX5, to kill nitric oxide. and vasodilation.
So end effect, you get
1) Extreme ROS from 1.25D and NADPH oxidase. ( scarring, calcification , etc) fibrosis. bone loss
2) You get high prolactin. since dopamine is constantly converted into Noradrenaline, since Noradrenaline is what activates A1A and remember they are downregulated
3) You get Gaba problems.
Cure is take DHT or steroids with A1A blocker. this will do 2 things
Downregulates DHT AR proteins, which are way too much and also it will upregulate A1A , which then will allow androgens to work.
In PFS the opposite happened, receptors for DHT got upregulated , and receptors for A1A downregulated. Their balance controls the prostate health of vasoconstriction and expansion.
And it will lower Dopamine to noradrenaline conversion. your dopamine will go up and you will have the drive.
And it will restore prostate weight, And it will stop NOX5 activation.
B) P. S We can also take into account, another variant when the balance of DHT to A1A went into A1A side. since some studies, also talked about upregulation of A1A after androgen deprivation.
C) Also just to throw things in. Lets say if the cell collected too much copper, it would be constant activation of dopamine into noradrenaline. Since copper runs the enzyme which converts dopamine into noradrenaline.
Noradrenaline will activate A1A receptor. Which would effect androgen action. Since there needs to be a balance between them
SO this is another possibility.
So we have 3 variants here. with A1A
Let's discuss this.
and I will try to come up with ideas for all 3 variants
