Brainstorming & Ideas (PFS - Gbol)

[Helen]

I dont knoe what is Depo provera. I repeat the same, the first study that declared that PFS patientes had 5ar metabolites on very low ratios compared to controls was in Dr. Melcangi study, if you have another study pointing to the contrary in open to see it.

I am not saying metabolites are not low. I am saying that I knew they were low even without you telling me about some study. this study is not important to me. I based my research on depo provera which already told me that metabolites will be down.

Low metabolites does not provide you with the solution. LOL there is still no cure for depo provera after 20 year or 30 years of research, although it is researched a lot better and tons of Melcangi like studies done on it.


No one knows how to regulate 5 alpha 1. LOL

and I am telling you how. Just go take resveratrol and see your 5 alpha 1 go on. You dont even know that it is 5 alpha 1

 

[BeLikeWater]

I can make a cycle no problems, do I expect it to work like snapback? Any recommendations om how to use it?

 

[wuf]

I dont knoe what is Depo provera. I repeat the same, the first study that declared that PFS patientes had 5ar metabolites on very low ratios compared to controls was in Dr. Melcangi study, if you have another study pointing to the contrary in open to see it.

I am not saying metabolites are not low. I am saying that I knew they were low even without you telling me about some study. this study is not important to me. I based my research on depo provera which already told me that metabolites will be down.

Low metabolites does not provide you with the solution. LOL there is still no cure for depo provera after 20 year or 30 years of research, although it is researched a lot better and tons of Melcangi like studies done on it.


No one knows how to regulate 5 alpha 1. LOL

and I am telling you how. Just go take resveratrol and see your 5 alpha 1 go on. You dont even know that it is 5 alpha 1

There are pfs surfers with high estrogens and still suffering.
Resvestrol would be the cure otherwise.

 

[Helen]

I can make a cycle no problems, do I expect it to work like snapback? Any recommendations om how to use it?

I think you should be good on it. it will increase estrogen signaling. And I think it will stick if you quit

 

[Helen]

I dont knoe what is Depo provera. I repeat the same, the first study that declared that PFS patientes had 5ar metabolites on very low ratios compared to controls was in Dr. Melcangi study, if you have another study pointing to the contrary in open to see it.

I am not saying metabolites are not low. I am saying that I knew they were low even without you telling me about some study. this study is not important to me. I based my research on depo provera which already told me that metabolites will be down.

Low metabolites does not provide you with the solution. LOL there is still no cure for depo provera after 20 year or 30 years of research, although it is researched a lot better and tons of Melcangi like studies done on it.


No one knows how to regulate 5 alpha 1. LOL

and I am telling you how. Just go take resveratrol and see your 5 alpha 1 go on. You dont even know that it is 5 alpha 1

There are pfs surfers with high estrogens and still suffering.
Resvestrol would be the cure otherwise.

the ones with high estrogen needs to take care of their prolactin

If you feel bad on copper, try to increase estrogen signaling by resveratrol, it will chelate free copper and this will increase estrogen signaling

 

[Shadow]

I dont knoe what is Depo provera. I repeat the same, the first study that declared that PFS patientes had 5ar metabolites on very low ratios compared to controls was in Dr. Melcangi study, if you have another study pointing to the contrary in open to see it.

Depo provera is Medroxyprogesterone, its used for chemical castration.

What I think that gbolduev is trying to say is that yes, the metabolites are low, but making them go up will not kick the body back to a normal state since something else is keeping them low.

 

[Helen]

I dont knoe what is Depo provera. I repeat the same, the first study that declared that PFS patientes had 5ar metabolites on very low ratios compared to controls was in Dr. Melcangi study, if you have another study pointing to the contrary in open to see it.

Depo provera is Medroxyprogesterone, its used for chemical castration.

What I think that gbolduev is trying to say is that yes, the metabolites are low, but making them go up will not kick the body back to a normal state since something else is keeping them low.

You are PSSD person , right. I was thinking about PSSD. Basically , you give SRRI, you overload the system with serotonin.

What do we get when we overload it with serotonin. We increase MAO A , right ? to break down this extra serotonin.

MAO A is vitamin b2 and copper.


Did you guys measure serotonin levels? after you quit SSRI?

 

[BeLikeWater]

btw Im in a Spanish group of PFS sufferers and we all have high prolactin, I started having twice the value of the higher extreme? at that time looking at women was like looking at furniture, and during the years has come back to the higher part of the range and my libido and secondary have been getting better, I dont know if that adds slmething to the conversation or not. I will try resvetratol lets see how it goes. Thaks

 

[Shadow]

I dont knoe what is Depo provera. I repeat the same, the first study that declared that PFS patientes had 5ar metabolites on very low ratios compared to controls was in Dr. Melcangi study, if you have another study pointing to the contrary in open to see it.

Depo provera is Medroxyprogesterone, its used for chemical castration.

What I think that gbolduev is trying to say is that yes, the metabolites are low, but making them go up will not kick the body back to a normal state since something else is keeping them low.

You are PSSD person , right. I was thinking about PSSD. Basically , you give SRRI, you overload the system with serotonin.

What do we get when we overload it with serotonin. We increase MAO A , right ? to break down this extra serotonin.

MAO A is vitamin b2 and copper.


Did you guys measure serotonin levels? after you quit SSRI?

Yes PSSD. Never tested my serotonin lvls, but I dont think that serotonin is the main problem, 3a-HSD is affected too, Im more inclined to think that the problem is similar to pfs but done by messing with 3a-hsd. But I can test my serotonin, no problems.

 

[wuf]

I am not saying metabolites are not low. I am saying that I knew they were low even without you telling me about some study. this study is not important to me. I based my research on depo provera which already told me that metabolites will be down.

Low metabolites does not provide you with the solution. LOL there is still no cure for depo provera after 20 year or 30 years of research, although it is researched a lot better and tons of Melcangi like studies done on it.


No one knows how to regulate 5 alpha 1. LOL

and I am telling you how. Just go take resveratrol and see your 5 alpha 1 go on. You dont even know that it is 5 alpha 1

There are pfs surfers with high estrogens and still suffering.
Resvestrol would be the cure otherwise.

the ones with high estrogen needs to take care of their prolactin

If you feel bad on copper, try to increase estrogen signaling by resveratrol, it will chelate free copper and this will increase estrogen signaling

Will think about it. Hope it would be so simple.
Thanks.

 

[Jaxx]

I dont knoe what is Depo provera. I repeat the same, the first study that declared that PFS patientes had 5ar metabolites on very low ratios compared to controls was in Dr. Melcangi study, if you have another study pointing to the contrary in open to see it.

Depo provera is Medroxyprogesterone, its used for chemical castration.

What I think that gbolduev is trying to say is that yes, the metabolites are low, but making them go up will not kick the body back to a normal state since something else is keeping them low.

You are PSSD person , right. I was thinking about PSSD. Basically , you give SRRI, you overload the system with serotonin.

What do we get when we overload it with serotonin. We increase MAO A , right ? to break down this extra serotonin.

MAO A is vitamin b2 and copper.


Did you guys measure serotonin levels? after you quit SSRI?

As far as i know. no reliable test is really available for this. For TCA's they do test blood serum at the beginning of therapy, but never serotonine, dopamine levels. Only thing alot of PSSD sufferers report is high prog.

 

[Helen]

ok, you increase serotonin, this increases ACTH and cortisol. increased cortisol causes potassium waste and sodium retention and alkalosis with expansion. Do you have blood tests?

 

[Helen]

Depo provera is Medroxyprogesterone, its used for chemical castration.

What I think that gbolduev is trying to say is that yes, the metabolites are low, but making them go up will not kick the body back to a normal state since something else is keeping them low.

You are PSSD person , right. I was thinking about PSSD. Basically , you give SRRI, you overload the system with serotonin.

What do we get when we overload it with serotonin. We increase MAO A , right ? to break down this extra serotonin.

MAO A is vitamin b2 and copper.


Did you guys measure serotonin levels? after you quit SSRI?

As far as i know. no reliable test is really available for this. For TCA's they do test blood serum at the beginning of therapy, but never serotonine, dopamine levels. Only thing alot of PSSD sufferers report is high prog.

Progesterone is raised when you have potassium deficiency.

potassium deficiency turns off the whole axis. that is why DHEA can crash you , since it lowers whole corticosteroid pathway, by tanking iron. And this lowers potassium and thus lowers cortisol.

that is why on Ray peat forum they say DHEA lowers cortisol, they dont undertstand that it lowers potassium and that is why cortisol falls not to kill you.

 

[Shadow]

ok, you increase serotonin, this increases ACTH and cortisol. increased cortisol causes potassium waste and sodium retention and alkalosis with expansion. Do you have blood tests?

Yes, https://www.hackstasis.com/viewtopic.php?f=61&t=236&p=4343#p4343

 

[Jaxx]

You are PSSD person , right. I was thinking about PSSD. Basically , you give SRRI, you overload the system with serotonin.

What do we get when we overload it with serotonin. We increase MAO A , right ? to break down this extra serotonin.

MAO A is vitamin b2 and copper.


Did you guys measure serotonin levels? after you quit SSRI?

As far as i know. no reliable test is really available for this. For TCA's they do test blood serum at the beginning of therapy, but never serotonine, dopamine levels. Only thing alot of PSSD sufferers report is high prog.

Progesterone is raised when you have potassium deficiency.

potassium deficiency turns off the whole axis. that is why DHEA can crash you , since it lowers whole corticosteroid pathway, by tanking iron. And this lowers potassium and thus lowers cortisol.

that is why on Ray peat forum they say DHEA lowers cortisol, they dont undertstand that it lowers potassium and that is why cortisol falls not to kill you.

Building on that, there are some things that gave people with PSSD windows (feeling of 100% relieve) but only for a small week or so. Little is known why.
Examples are Saint Johns Wort, Moclobemide, Mianserin, Estrogen+DHT. Any idea why SJW for instance would help but not only for a short term?
Curious if these things have also been tried with the PFS community

 

[Shadow]

As far as i know. no reliable test is really available for this. For TCA's they do test blood serum at the beginning of therapy, but never serotonine, dopamine levels. Only thing alot of PSSD sufferers report is high prog.

Progesterone is raised when you have potassium deficiency.

potassium deficiency turns off the whole axis. that is why DHEA can crash you , since it lowers whole corticosteroid pathway, by tanking iron. And this lowers potassium and thus lowers cortisol.

that is why on Ray peat forum they say DHEA lowers cortisol, they dont undertstand that it lowers potassium and that is why cortisol falls not to kill you.

Building on that, there are some things that gave people with PSSD windows (feeling of 100% relieve) but only for a small week or so. Little is known why.
Examples are Saint Johns Wort, Moclobemide, Mianserin, Estrogen+DHT. Any idea why SJW for instance would help but not only for a short term?
Curious is these things have also been tried with the PFS community

I had a week with full recovery from sexual problems on the second week of trying to reinstate the ssri, after that, I was left with so many side effects, that I dont know how I dindt killed myself... I know of only 3 people with the same severity os symptoms like me.

SJW has so many molecules that is very hard to guess something, maybe it was the MAO inhibition effect.

 

[Helen]

ok, you increase serotonin, this increases ACTH and cortisol. increased cortisol causes potassium waste and sodium retention and alkalosis with expansion. Do you have blood tests?

Yes, https://www.hackstasis.com/viewtopic.php?f=61&t=236&p=4343#p4343

Cool I will look at your results tomorrow. interesting.

 

[wuf]

You are PSSD person , right. I was thinking about PSSD. Basically , you give SRRI, you overload the system with serotonin.

What do we get when we overload it with serotonin. We increase MAO A , right ? to break down this extra serotonin.

MAO A is vitamin b2 and copper.


Did you guys measure serotonin levels? after you quit SSRI?

As far as i know. no reliable test is really available for this. For TCA's they do test blood serum at the beginning of therapy, but never serotonine, dopamine levels. Only thing alot of PSSD sufferers report is high prog.

Progesterone is raised when you have potassium deficiency.

potassium deficiency turns off the whole axis. that is why DHEA can crash you , since it lowers whole corticosteroid pathway, by tanking iron. And this lowers potassium and thus lowers cortisol.

that is why on Ray peat forum they say DHEA lowers cortisol, they dont undertstand that it lowers potassium and that is why cortisol falls not to kill you.

Then potassium deficiency= raised progesterone and low cortisol.
BUT
I have low progesterone (blood tests) and relative low cortisol (saliva test).
Potassium in ranges (hair and blood tests)

 

[Jaxx]

Do you also see a thyroid connection here? Although difficult to explain, i always felt a pressure on my thyroid/throat when a window appeared. Furthermore i noticed several elevated TSH tests on the PSSD forum (no impact on t3/t4, so often without follow up)

 

[expendable]

wanted to throw in that I had like, a 99% window with 450mg licorice root over 2 days and 1 capsule of kudzu root (dont remember dosage), was 99% 3 days later, then declined over the next few days to baseline.