Brainstorming & Ideas (PFS - Gbol)

[aztec]

Re: Gbold's Theory

<r><QUOTE author="gbolduev" post_id="532" time="1507395570" user_id="90"><s>

</s>
<QUOTE author="TubZy" post_id="529" time="1507395142" user_id="2"><s>

</s>
<QUOTE author="gbolduev" post_id="525" time="1507394294" user_id="90"><s>

</s>
Yeah he used only one pill.
<e>

</e></QUOTE>

At high doses RU was shown to be anti androgenic, what mechanism do you think that is from? From it being a progestin at higher doses?<br/>
<br/>
Do you know if ella has anti andro properties?
<e>

</e></QUOTE>

May be it is a progestin at higher doses, when progesterone really falls.<br/>
<br/>
I have read that Ella effect cortiol and ar very weakly
<e>

</e></QUOTE>
What if ru 486 was ran identically to the successful Ella cycle? Same dose and durartion period. 5mg once daily for 6 days. No one has tried it yet but was curious about your thoughts guys.</r>

 

[Helen]

Re: Gbold's Theory

<r><QUOTE author="aztec" post_id="535" time="1507396160" user_id="52"><s>

</s>
<QUOTE author="gbolduev" post_id="532" time="1507395570" user_id="90"><s>

</s>
<QUOTE author="TubZy" post_id="529" time="1507395142" user_id="2"><s>

</s>
<br/>
<br/>
At high doses RU was shown to be anti androgenic, what mechanism do you think that is from? From it being a progestin at higher doses?<br/>
<br/>
Do you know if ella has anti andro properties?
<e>

</e></QUOTE>

May be it is a progestin at higher doses, when progesterone really falls.<br/>
<br/>
I have read that Ella effect cortiol and ar very weakly
<e>

</e></QUOTE>
What if ru 486 was ran identically to the successful Ella cycle? Same dose and durartion period. 5mg once daily for 6 days. No one has tried it yet but was curious about your thoughts guys.
<e>

</e></QUOTE>

I think first we need to see what happens after the current cycles to adjust the dosages</r>

 

[aztec]

Re: Gbold's Theory

<t>Sounds good gbolduev.</t>

 

[joekool]

Re: Gbold's Theory

<r><QUOTE author="BeLikeWater" post_id="522" time="1507393450" user_id="112"><s>

</s>
Btw I have had extremly good results lately, maybe cycling 5dhp 3 times had an effect... first time was amazing, taste for music back, my original sexuality back, emotions back, much better sleep and less anxiety.... but improvements dissapeared with time, but I did cycled it for a week 2 times, they were not exactly cycled I just took it when I needed or I remember. Anyways this past 2 weeks I finally had libido through the roof, but Im also have beenworking on lowering Serotonin for example, and increasing 5ar activity and treating my body as it had autoinmune issues that I think we have.
<e>

</e></QUOTE>

Hey <MENTION><s>[mention]</s>BeLikeWater<e>[/mention]</e></MENTION> , what are some of the steps you're taking on lowering Serotonin, increasing 5ar , etc...<br/>
<br/>
For example, Glycine 6G before bed is decent for 5ar... etc??</r>

 

[TubZy]

Re: Gbold's Theory

<r><QUOTE author="gbolduev" post_id="536" time="1507396454" user_id="90"><s>

</s>
<QUOTE author="aztec" post_id="535" time="1507396160" user_id="52"><s>

</s>
<QUOTE author="gbolduev" post_id="532" time="1507395570" user_id="90"><s>

</s>
<br/>
<br/>
May be it is a progestin at higher doses, when progesterone really falls.<br/>
<br/>
I have read that Ella effect cortiol and ar very weakly
<e>

</e></QUOTE>
What if ru 486 was ran identically to the successful Ella cycle? Same dose and durartion period. 5mg once daily for 6 days. No one has tried it yet but was curious about your thoughts guys.
<e>

</e></QUOTE>

I think first we need to see what happens after the current cycles to adjust the dosages
<e>

</e></QUOTE>

How long does RU take to fully leave your system? I know you said 2-3 weeks is that in reference to the actual drug being cleared out of the system or is that taking into consideration receptors being restored/sensitive?</r>

 

[Helen]

Re: Gbold's Theory

<t>I am not sure about RU half life. I think it is pretty long. How long will it take to clear the system. May be the same amount of days you were on it at least</t>

 

[Helen]

Re: Gbold's Theory

<r><MENTION><s>[mention]</s>BeLikeWater<e>[/mention]</e></MENTION> <br/>
<br/>
Many people after finasteride lose potassium and low blood potassium does not allow insulin release. it is almost like steroids diabetes. Half people after finasteride have this situation and half have very high insulin.<br/>
<br/>
this happens because insulin puts potassium inside of the cell. Doctors use insulin during hyperkalemia to put potassium inside of the cell. During alkalosis from low potassium or potassium already high in the cell<br/>
<br/>
Insulin release is inhibited.<br/>
<br/>
Finasteride leaves many people with alklaosis with volume increase. that is why I recommended for those people magnesium potassium and copper , first , and then add manganese and zinc<br/>
<br/>
Progesterone is raised to retain potassium.</r>

 

[Minime]

Re: Gbold's Theory

<t>Will a blood analysis show if someone has alkalosis?</t>

 

[SunJeep]

Re: Gbold's Theory

<r><QUOTE author="gbolduev" post_id="549" time="1507400339" user_id="90"><s>

</s>
@BeLikeWater <br/>
<br/>
Many people after finasteride lose potassium and low blood potassium does not allow insulin release. it is almost like steroids diabetes. Half people after finasteride have this situation and half have very high insulin.<br/>
<br/>
this happens because insulin puts potassium inside of the cell. Doctors use insulin during hyperkalemia to put potassium inside of the cell. During alkalosis from low potassium or potassium already high in the cell<br/>
<br/>
Insulin release is inhibited.<br/>
<br/>
Finasteride leaves many people with alklaosis with volume increase. that is why I recommended for those people magnesium potassium and copper , first , and then add manganese and zinc<br/>
<br/>
Progesterone is raised to retain potassium.
<e>

</e></QUOTE>

Interesting. I think I fall in the low insulin category (given bloods show high fasting glucose but low insulin and normal A1G)<br/>
<br/>
How much magnesium potassium copper would you recommend and how long before adding the manganese and zinc? <br/>
<br/>
I also have RU but due to traveling I’d prefer to wait to do a proper trial.</r>

 

[ruprmurdoch]

Re: Gbold's Theory

<r><QUOTE author="gbolduev" post_id="549" time="1507400339" user_id="90"><s>

</s>
@BeLikeWater <br/>
<br/>
Many people after finasteride lose potassium and low blood potassium does not allow insulin release. it is almost like steroids diabetes. Half people after finasteride have this situation and half have very high insulin.<br/>
<br/>
this happens because insulin puts potassium inside of the cell. Doctors use insulin during hyperkalemia to put potassium inside of the cell. During alkalosis from low potassium or potassium already high in the cell<br/>
<br/>
Insulin release is inhibited.<br/>
<br/>
Finasteride leaves many people with alklaosis with volume increase. that is why I recommended for those people magnesium potassium and copper , first , and then add manganese and zinc<br/>
<br/>
Progesterone is raised to retain potassium.
<e>

</e></QUOTE>

<br/>
could you clarify:<br/>
1. low insulin------ take: magnesium potassium and copper<br/>
high insulin-------take: ???????<br/>
<br/>
2. what dosages of magnesium potassium (potassium chloride) and copper ?</r>

 

[freeflow]

Re: Gbold's Theory

<r><QUOTE author="gbolduev" post_id="549" time="1507400339" user_id="90"><s>

</s>
@BeLikeWater <br/>
<br/>
Many people after finasteride lose potassium and low blood potassium does not allow insulin release. it is almost like steroids diabetes. Half people after finasteride have this situation and half have very high insulin.<br/>
<br/>
this happens because insulin puts potassium inside of the cell. Doctors use insulin during hyperkalemia to put potassium inside of the cell. During alkalosis from low potassium or potassium already high in the cell<br/>
<br/>
Insulin release is inhibited.<br/>
<br/>
Finasteride leaves many people with alklaosis with volume increase. that is why I recommended for those people magnesium potassium and copper , first , and then add manganese and zinc<br/>
<br/>
Progesterone is raised to retain potassium.
<e>

</e></QUOTE>

Hey @gbolduev, nice to see you here.<br/>
My case is high potassium in the cell(1.5 times higher than upper range)<br/>
I did a blood test too and my progesterone is 1.3nmol/L (range: 0.89-3.9) <br/>
<br/>
I have high potassium, low progesterone(?), im in metabolic alkalosis. <br/>
It seems im the exact case as you were when you had pfs and you upregulated your estrogen with clomid and added zinc when coming off.<br/>
My questions: <br/>
1, High progesterone protocol will also work for me?<br/>
2, any natural methylation protocol to cure this? Like thorne, exercise or something, multivitamin<br/>
3, pine pollen makes me feel worse but when i go off of it in some days my old libido feeling appears then it stays for some days and i crash naturally. By crash i mean head pressure appears, i develop diarrhea etc.Then in 1-2 weeks i get back to basic pfs baseline. This crash is induced by either orgasm or it comes naturally. Thorne extra should prevent this crash?<br/>
4, in a topic i just saw you wrote serotonin causes diarrhoea. Whenever i crash after achieving a partial recovery i always have diarrhoea!! Then it leaves after some days when im back to baseline. What the hell is this really serotonin, how could i prevent this??<br/>
<br/>
<br/>
Thank you for your help, really appreciated because the comments you wrote on ray peat were describing my situation all the time, matchig all my experience.<br/>
<br/>
@gbolduev</r>

 

[TeslaFan]

Re: Gbold's Theory

<r><QUOTE author="gbolduev" post_id="549" time="1507400339" user_id="90"><s>

</s>
<br/>
Finasteride leaves many people with alklaosis with volume increase. that is why I recommended for those people <B><s></s>magnesium potassium and copper , first <e></e></B>, and then add manganese and zinc<br/>
<br/>
Progesterone is raised to retain potassium.
<e>

</e></QUOTE>

I think this is the real long term cure for both PFS and PSSD. <br/>
All PFS/PSSD people should place the words above as a desktop background on their computers, and/or meditate daily on it <E></E></r>

 

[5 alpha]

Re: Gbold's Theory

<r><QUOTE author="gbolduev" post_id="549" time="1507400339" user_id="90"><s>

</s>
<br/>
Many people after finasteride lose potassium and low blood potassium does not allow insulin release. it is almost like steroids diabetes. Half people after finasteride have this situation and half have very high insulin.<br/>
<br/>
this happens because insulin puts potassium inside of the cell. Doctors use insulin during hyperkalemia to put potassium inside of the cell. During alkalosis from low potassium or potassium already high in the cell<br/>
<br/>
Insulin release is inhibited.<br/>
<br/>
Finasteride leaves many people with alklaosis with volume increase. that is why I recommended for those people magnesium potassium and copper , first , and then add manganese and zinc<br/>
<br/>
Progesterone is raised to retain potassium.
<e>

</e></QUOTE>

Gbold, good to see you here. I hope all is well.<br/>
<br/>
This point about some people having low and some people having high insulin after coming off is interesting. I had low blood sugar for several months confirmed by more than one set of labs after getting PFS.<br/>
<br/>
So obviously my unexplained low blood sugar after getting PFS probable means my insulin was too high right?<br/>
<br/>
if my insulin was high what conclusions can be drawn regarding potassium?</r>

 

[5 alpha]

Re: Gbold's Theory

<r><QUOTE author="gbolduev" post_id="536" time="1507396454" user_id="90"><s>

</s>
<QUOTE author="aztec" post_id="535" time="1507396160" user_id="52"><s>

</s>
<QUOTE author="gbolduev" post_id="532" time="1507395570" user_id="90"><s>

</s>
<br/>
<br/>
May be it is a progestin at higher doses, when progesterone really falls.<br/>
<br/>
I have read that Ella effect cortiol and ar very weakly
<e>

</e></QUOTE>
What if ru 486 was ran identically to the successful Ella cycle? Same dose and durartion period. 5mg once daily for 6 days. No one has tried it yet but was curious about your thoughts guys.
<e>

</e></QUOTE>

I think first we need to see what happens after the current cycles to adjust the dosages
<e>

</e></QUOTE>

I have my RU ready to go. If you can think of any particular way that you think I should run mine so that we can compare my results to Ihatefin, Jkool and Tubz's results please let me know.</r>

 

[TubZy]

Re: Gbold's Theory

<r><QUOTE author="5 alpha" post_id="594" time="1507415907" user_id="57"><s>[quote="5 alpha" post_id=594 time=1507415907 user_id=57]</s>
<QUOTE author="gbolduev" post_id="536" time="1507396454" user_id="90"><s>

</s>
<QUOTE author="aztec" post_id="535" time="1507396160" user_id="52"><s>

</s>
<br/>
What if ru 486 was ran identically to the successful Ella cycle? Same dose and durartion period. 5mg once daily for 6 days. No one has tried it yet but was curious about your thoughts guys.
<e>

</e></QUOTE>

I think first we need to see what happens after the current cycles to adjust the dosages
<e>

</e></QUOTE>

I have my RU ready to go. If you can think of any particular way that you think I should run mine so that we can compare my results to Ihatefin, Jkool and Tubz's results please let me know.
<e>[/quote]</e></QUOTE>

Don't do what we did. I would say 3 days maximum and keep the dose lower like <MENTION><s>[mention]</s>IHateFin<e>[/mention]</e></MENTION> 's first cycle. I think 7 days may be too long, which is what we did the second time around and towards day 6-7 started to feel like crap.<br/>
<br/>
I think if you try the 3 day cycle at first that could give us great insight. If it does work and you feel better post RU, then I think we can differentiate RU's anti andro and progestin like effects.</r>

 

[aztec]

Re: Gbold's Theory

<r><QUOTE author="TubZy" post_id="596" time="1507416344" user_id="2"><s>

</s>
<QUOTE author="5 alpha" post_id="594" time="1507415907" user_id="57"><s>[quote="5 alpha" post_id=594 time=1507415907 user_id=57]</s>
<QUOTE author="gbolduev" post_id="536" time="1507396454" user_id="90"><s>

</s>
<br/>
<br/>
I think first we need to see what happens after the current cycles to adjust the dosages
<e>

</e></QUOTE>

I have my RU ready to go. If you can think of any particular way that you think I should run mine so that we can compare my results to Ihatefin, Jkool and Tubz's results please let me know.
<e>

</e></QUOTE>

Don't do what we did. I would say 3 days maximum and keep the dose lower like @IHateFin 's first cycle. I think 7 days may be too long, which is what we did the second time around and towards day 6-7 started to feel like crap.<br/>
<br/>
I think if you try the 3 day cycle at first that could give us great insight. If it does work and you feel better post RU, then I think we can differentiate RU's anti andro and progestin like effects.
<e>[/quote]</e></QUOTE>
TubZy, a 3 day cycle at 25 mg once daily sound good?</r>

 

[TubZy]

Re: Gbold's Theory

<r><QUOTE author="aztec" post_id="597" time="1507416716" user_id="52"><s>

</s>
<QUOTE author="TubZy" post_id="596" time="1507416344" user_id="2"><s>

</s>
<QUOTE author="5 alpha" post_id="594" time="1507415907" user_id="57"><s>[quote="5 alpha" post_id=594 time=1507415907 user_id=57]</s>
<br/>
<br/>
I have my RU ready to go. If you can think of any particular way that you think I should run mine so that we can compare my results to Ihatefin, Jkool and Tubz's results please let me know.
<e>

</e></QUOTE>

Don't do what we did. I would say 3 days maximum and keep the dose lower like @IHateFin 's first cycle. I think 7 days may be too long, which is what we did the second time around and towards day 6-7 started to feel like crap.<br/>
<br/>
I think if you try the 3 day cycle at first that could give us great insight. If it does work and you feel better post RU, then I think we can differentiate RU's anti andro and progestin like effects.
<e>

</e></QUOTE>
TubZy, a 3 day cycle at 25 mg once daily sound good?
<e>[/quote]</e></QUOTE>

I would say 25mg or 50mg. I wouldn't go anything over 50mg for sure though. I haven't personally tried 25mg, but maybe what you can try is 25mg or so 3 days in a row then stop it and wait like a week and see how you feel. If nothing do another 3 day cycle at 50mg and wait a week and see how you feel. <br/>
<br/>
I think that would a good way to experiment.</r>

 

[aztec]

Re: Gbold's Theory

<t>Sounds good TubZy. I feel like the small dosage and short cycle could be very effective considering my progesterone levels are slightly elevated by 0.1.</t>

 

[TubZy]

Re: Gbold's Theory

<r><QUOTE author="aztec" post_id="599" time="1507417823" user_id="52"><s>

</s>
Sounds good TubZy. I feel like the small dosage and short cycle could be very effective considering my progesterone levels are slightly elevated by 0.1.
<e>

</e></QUOTE>

Sweet. If you and @5 alpha try this method we should have some good results.</r>

 

[aztec]

Re: Gbold's Theory

<r><QUOTE author="TubZy" post_id="600" time="1507419173" user_id="2"><s>

</s>
<QUOTE author="aztec" post_id="599" time="1507417823" user_id="52"><s>

</s>
Sounds good TubZy. I feel like the small dosage and short cycle could be very effective considering my progesterone levels are slightly elevated by 0.1.
<e>

</e></QUOTE>

Sweet. If you and @5 alpha try this method we should have some good results.
<e>

</e></QUOTE>
Good stuff TubZy! I will get my ru 486 shortly. 5 alpha has it on hand. This will be helpful to track.</r>