I've been focused soley on androgen receptors which I believe is the source of PFS. I've researched and found some things to increase them.
L Carnitine L Tartrate at 2g a day
No orgasms help build them back up, which is why ppl claim nofap helps. Fasting does this too, upregulate the receptors I mean.
Mucuna Pruriens supposedly lowers prolactin if you want to try natural. One of the B's too but B6 has a negative effect on our penile sensitivity so, if it's that one, I'd avoid it
Pramipexole is a dopamine agonist that is pharma strength... That's one way to prove if it's prolactin.
If it's prolactin, going two to 3 weeks between sex despite the urge can help it, if you had a lower refractory period as you described. Say only a couple days...
Let us know what you experiment with
Carnitine lowers thyroid. when thyroid hormones are blocked. This asks for more progesterone. So conversion of progesterone to things stops. This lowers 5AR. so you get less DHT. And methylation increases to express more AR receptors. That is how carnitine increases methylation .
You neeed to understand that all substances do 2 things, if they upregulate methylation to express more of the receptor they kill DHT.
This is why carnitine is used for a fast oxidizer. carnitine carries fatty acids for oxidation. This increases methylation. and slows down the thyroid. which kills 5AR
Methylation expresses the receptors and keeps them expressed. This is why folinc acid gets rid of PFS for tallglass completely.
But people are already overmethylating. meaning overexpressing the receptor. This is what was found in italian study. SO PFS is not about insensitive receptor.
Testosterone downregulates methylation so it stops AR receptor overexpression.
In PFS people have low 5AR. that causes low testosterone to DHT conversion, and this causes methylation to go up huge and express extra receptors for the AR.
This is why increasing methylation even further helps PFS. You go on methylation supps, you express even more AR receptors and you start converting DHT into 3 adiol.
In Italian study they studied many people with PFS. and found that the expression of AR was high in all cases. You need to understand there is no magical receptor of the AR. the receptors are constantly expressed , it is an ongoing process. This is done with methylation. So if you are not methylating you are not expressing the AR, if you are overmethylating you are overexpressing the AR.
Since they found that expression of AR was high in all cases in PFS. Then we have 2 cases.
In one case expression of AR is a stilt, meaning there is not enough DHT since 5AR is not working.
In another case, overexpression of AR is the whole problem. and this causes 5AR to stop and high progesterone. which blocks aldo and cortisol reception.
When I took finasteride. I tested my blood. FIN totally suppressed my own progesterone. since fin is a progestin. but progestin does not convert into cortisol or allopregnenolone. and since progestin blocks your own progesterone. it stop 5AR this way.
So when you are on progestin. you get zero 5AR, and you have zero access to cortisol. And the body has to upregulate AR and GR which always go together up and down, since it is methylation,
When you quit fin, progesterone goes up, but progestin is still in blood for 2 weeks. This causes high 5ar , and still high methylation. so expression of AR. you feel androgenic.
But when progestin leave your body in 2 weeks. now you have to run on your own progesterone. But the receptor is downregulated big time, so progesterone does not convert into allopregnenolone, and stays high . and 5AR is closed down.
This forces teh body to upregulate methylation. It takes your copper and b vitamins and starts methylating like crazy. This is why if you test your urine , you will see zero copper there and high zinc.
Since the body is overmethylating , this spends all your b vitamins especically b1 and b2. This is why all pFS people have low reduced glutathione.
Low reduced glutathione decreases thyroid and increases reverse t3. and metabolism is lowered.
This is what deca dick is. Deca is DHT with a progestin. Fin= only progestin.
this is why they use testosterone with DECA, test does not allow 5AR to downregulate much.
This is why using test for deca dick downregulates the AR expression, Since it increases 5AR. Test pushes 5AR. This kills progesterone , this is why people feel lethargic on test, on any test 500, or 100. both lethargic, since test pushes 5AR, so increases DHT, and decreases Progesterone, but progestreone is already insensitive remember.
This is how test upregulates progesterone if you keep at it. this is why I suggested pinepollen and test from the beginning as a way to upregulate progesterone.
I think ella or ru can do this faster. but no one cycled it often or longer.
The reason some people have normal test and normal DHT is that test does not convert much into dht and the body downregulates 3 alpha hsd. This is why all pfs people have low 3 adiol.
If the problem laid in insensitive AR , then taking DHT would make people better. Same as if there is insensitive GR, taking dexamethasone makes people better,
But in case of PFS it does not. Why? since taking DHT will decrease 5AR. and in one case 5AR is already not working.
Bottom line, in both cases AR is overexpressed in PFS IMO. and it is proven in the offical study. SO it is silly to talk differently.
AR expression is not static. It is methylation. So stops and goes immediately. it does not stay . It can go from overexpression to under expression in a heart beat.
I think in one case AR is overexpressed and that is a problems , I think extra copper causes methylation to keep going. This is why some people cycle androsterone. which converts to DHT and this downregulates methylation so downregulates the expression of AR.
and in some cases overexpressed AR is the stilt , it is the outcome of very low 5AR. And in this case expression of the AR even higher makes you feel better. but it is not a good way to fix it.