Experimental Hair Loss Options

JonnyCraig

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"In a paper regarding evidence based guidelines in the treatment of alopecia for both women and men (Blumeyer et al.), various amino acids are mentioned with a special mention for cysteine. Cysteine is considered to be one of the main factors involved in hair growth.

The group that also followed the dietary supplement had a 50% increase in hair growth.

The paper cites a study (Morganti et al.) where there was a significant mean change of total hair count in both male and female patients after a treatment containing cysteine.
The participants had to take an oral supplement that contained cysteine, copper, zinc and histidine 4 times a day for 50 weeks and the treatment group had remarkable results with their anagen rate."

"The amount of cysteine in a hair fibre is an indicator of the hairs health. (J Cell Biol. 1990) In various animals, cysteine, along with other amino-acids and proteins, can protect hair and feathers and help them establish mechanical resilience. (Strasser et al., 2015)"

"Another study suggests that l-cysteine prevents the reduction in keratin synthesis induced by iron deficiency in human keratinocytes. It seems that l-cysteine promotes an important up regulation of keratins expression in the de novo protein synthesis and it counteracts the adverse effect of iron deficiency in keratin expression. (Miniaci et al., 2016)"

"The groups of mice received three dose levels of l-cysteine and vitamin B6 daily. Vitamin B6 was used due to its important role in incorporating l-cysteine in hair cells. After 6 months of exposure, the results showed that mice receiving the most l-cysteine/vitamin B6 doses had less hair loss, concluding that oral administration of vitamin B6 and l-cysteine may be an effective preventive treatment in alopecia. (D’Agostini et al., 2007)"
 

JonnyCraig

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Alanine seems to be super important as well (not to be confused with Beta-Alanine).

Histidine, BCAA's..serum folate levels (this is huge, 91% of people with MPHL had low serum folate levels in this study)..copper, also.

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Aleksandr

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Alanine seems to be super important as well (not to be confused with Beta-Alanine).

Histidine, BCAA's..serum folate levels (this is huge, 91% of people with MPHL had low serum folate levels in this study)..copper, also.

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Wow thats interesting. Female hair loss looks to require much greater deficits than male hair loss which seems to relate to reality too.
 

Helen

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Cysteine is 50/50 here. Beta alanine= alanine. Some people already took it in form of b5 and lowered their histidine levels even lower. Alanine is lost in urine in histidine deficiency . Folate is lost in histidine deficiency since there is no stomach acid. And also folate is what breaks down histidine.

Follow zinc finger , it is all there
 

JonnyCraig

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Cysteine is 50/50 here. Beta alanine= alanine. Some people already took it in form of b5 and lowered their histidine levels even lower. Alanine is lost in urine in histidine deficiency . Folate is lost in histidine deficiency since there is no stomach acid. And also folate is what breaks down histidine.

Follow zinc finger , it is all there

Wait... what?

Isn't L-Alanine different from Beta-Alanine????? like, very different?

I just ordered L-Alanine, 1kg.

As far as I know, they are different, and Alanine doesn't deplete Taurine.. does it??

Also you say... B5 = Cysteine?! OR you're saying B5 = alanine?

Sorry can you please confirm. Slightly confused.

I just purchased L-Cysteine, L-Histidine, L-Alanine.
 

JonnyCraig

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b5 has beta- alanine in it.

Are you sure about this claim? Look below:

"Low levels of alanine have been found in patients with hypoglycemia, diabetes, and hepatitis—it is not known at this time if alanine deficiency is the cause or result of these diseases. The body must have alanine to process the B vitamins so necessary for good health, especially vitamin B5(pantothenic acid) and vitamin B6 (pyridoxine)."

From my research, Beta-Alanine is something completely different, and not to be confused with L-Alanine.

» Difference between alanine and beta-alanine

I'm certainly not trying to fight, however I just ordered 1kg of L-Alanine, after some research. If Alanine was Beta-Alanine, I would have just ordered that (and I used to use Beta-Alanine back in the day for weight lifting).

If B5 has Alanine in it, and you can confirm this, I would be very hesitant on starting to take L-Alanine at all.
 

JDreamer

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I gave up all protein supplements about 2 months ago. I truly believe I was stressing my system out from over-consumption.

I get the protein that I need just fine from my meals, but I have been supplementing a BCAA drink two times a day - especially since protein essentially breaks down into aminos (going right to the source). Gone is the ammonia smell I was experiencing in my sweat. I've also noticed that my crown is improving and I haven't lost my gains in the gym, which I was very worried about at first. However, I'm still receding in the front. I'm curious if that's because I'm over-supplementing Zinc.
 

Helen

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Alanine was the highest deficiency in EAA's, in that study, among men with MPHL.

One of the reasons I bought some.


Read my post LOL It says b5 has beta alanine in it

Read zinc finger protocol.

Alanine is a part of the protocol

But if you have b5 overload. I would go easy on it at first.
 
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TubZy

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I gave up all protein supplements about 2 months ago. I truly believe I was stressing my system out from over-consumption.

I get the protein that I need just fine from my meals, but I have been supplementing a BCAA drink two times a day - especially since protein essentially breaks down into aminos (going right to the source). Gone is the ammonia smell I was experiencing in my sweat. I've also noticed that my crown is improving and I haven't lost my gains in the gym, which I was very worried about at first. However, I'm still receding in the front. I'm curious if that's because I'm over-supplementing Zinc.

Yeah excess protein is also harder on the kidneys while BCAAs are not and actually can support the kidneys
 

JDreamer

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Yeah excess protein is also harder on the kidneys while BCAAs are not and actually can support the kidneys

Just wish I had investigated things sooner. Once I did, the connection with the ammonia smell started making sense. My protein ratio was waaaaaaaay out of wack for far too long.

Seriously though, the protein supplement industry is such a hack.
 

Helen

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@TubZy
Leucine was also very low in hairloss.
Once histidine goes back on line. everything goes back online. No reason to oversupplement. that is why I dont like those amino acid complexes many aminos in bad ratios. aminos simply not being utilized nor digested. Especially glutamic acid, added BCAAs, etc. Garbage amino acid complexes.

Body cant choose which one to digest unfortunately. this is not a mineral

@JDreamer zinc lowers histidine. And histidine with cysteine are needed to transport biotin from the intestine into blood.

thus if you are missing sulfuric amino acids and histidine, you will be missing biotin.
 
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JDreamer

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@TubZy
Leucine was also very low in hairloss.
Once histidine goes back on line. everything goes back online. No reason to oversupplement. that is why I dont like those amino acid complexes many aminos in bad ratios. aminos simply not being utilized nor digested. Especially glutamic acid, added BCAAs, etc. Garbage amino acid complexes.

Body cant choose which one to digest unfortunately. this is not a mineral

@JDreamer zinc lowers histidine. And histidine with cysteine are neede to transport biotin from the instestine into blood.

Thus hairloss, if they are missing.

Is this the wrong mix/ratio? It's in the Modern BCAA drink I'm currently taking.

modern-bcaa-ingredients.png
 

Helen

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Is this the wrong mix/ratio? It's in the Modern BCAA drink I'm currently taking.

View attachment 161


Well you got some of the aminos in this, We posted studies with which aminos are low in hairloss. Look them up. Leucine is low, histidine is low, cysteine 50/50. alanine is low. So you got some of them. but I bet the most important one is histidine. without it NO BIOTIN


Involvement of histidine residues and sulfhydryl groups in the function of the biotin transport carrier of rabbit intestinal brush-border membrane - ScienceDirect

http://www.physiology.org/doi/10.1152/ajpcell.1999.277.4.C605
 
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TubZy

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Well you got some of the aminos in this, We posted studies with which aminos are low in hairloss. Look them up. Leucine is low, histidine is low, cysteine 50/50. alanine is low. So you got some of them. but I bet the most important one is histidine. without it NO BIOTIN


Involvement of histidine residues and sulfhydryl groups in the function of the biotin transport carrier of rabbit intestinal brush-border membrane - ScienceDirect

http://www.physiology.org/doi/10.1152/ajpcell.1999.277.4.C605

His BCAA also contains potassium too
 

Helen

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His BCAA also contains potassium too

yeah, it is good. remember that study where USSR used histidine arginine, plus lysine along with potassium to get rid of alkalosis

And we see low copper, low folate, low potassium , low histidine in hairloss.

No wonder, copper breaks down, histidine, folate breaks down histidine, Leucine causes extra need for aminos, and histidine is needed for their absorption so probably lost in the urine.

It would be interesting to see which aminos are actually lost in the urine
 
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TubZy

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Are you sure about this claim? Look below:

"Low levels of alanine have been found in patients with hypoglycemia, diabetes, and hepatitis—it is not known at this time if alanine deficiency is the cause or result of these diseases. The body must have alanine to process the B vitamins so necessary for good health, especially vitamin B5(pantothenic acid) and vitamin B6 (pyridoxine)."

From my research, Beta-Alanine is something completely different, and not to be confused with L-Alanine.

» Difference between alanine and beta-alanine

I'm certainly not trying to fight, however I just ordered 1kg of L-Alanine, after some research. If Alanine was Beta-Alanine, I would have just ordered that (and I used to use Beta-Alanine back in the day for weight lifting).

If B5 has Alanine in it, and you can confirm this, I would be very hesitant on starting to take L-Alanine at all.

Beta alanine and alanine are different. you got the right one I confirmed with @gbolduev as I also have beta alanine so wanted to confirm too