Yeah, that's the same dude I refered to heh! Helen was unhinged in the way he wrote and expressed his ideas, as if he was in an infinite hurry ))))))))
This guy is more chill, uses translator, lives in Russia. Content and ideas - that's the same, yeah.
I just checked my discord - the last I spoke to him was this exact day last year. Literally 17th of August 2024 lol, what a coincidence (and I somehow missed the message and left him on read, rip). At that time he was very fucked up and in the middle of a crash induced by rhodiola. He then mentioned that he's thinking of cycling dexamethasone.
But recently a friend told me that this guy told him on reddit that he is now recovered and that he recovered by basically cycling dexamethasone 0.5mg for half a year.
Eh, who knows, I kinda find it hard to believe because his symptoms were crazy back then. But I do hope he recovered, he was nice and proactive, experimented a lot.
You telling me this is a different guy...? :
"Why is it not clear? Probiotics do not need to be passed through the small intestine. If they are injected, then through an enema.
PFS = shitty bile, hence the rise in SIBO, inflammation and symptoms. There is no point in treating the consequence, but to maintain the symptoms, you can drink primary bile acids"
"DHEA inhibits G6PD. That's why it works. Many people with POIS will get worse on DHEA. It is not a cure, just a plug, which can make it worse if you take it for a long time. "
"Boy, you don't seem to understand the word modulation. Modulation is regulation, not upregulation/downregulation or even receptor upregulation/downregulation. Only the body modulates, all drugs and supplements bypass regulation by affecting other pathways (enzymes, receptors, minerals, etc) and throw off your chemistry eventually, some more, some less, some permanently.
GABA pushes chloride and potassium into the cell (receptor dependent). Glutamate does it with calcium. So for example, noradrenaline via a1 increases glutamate. Noradrenaline activates phospholipase C. Phospholipase breaks down inositophosphate into IP3 and DAG. IP3 is what causes calcium channels to open and calcium to enter the cell.
Same with glycine, if there is no chloride in the cell, will go to glutamate instead of GABA, increasing oxidative stress and agitation instead of the expected decrease in anxiety. That's why there are tons of people with POIS who have alkolosis with loss of chloride.
GABA and glutamate are direct antagonists and to say they have nothing to do with each other is kindergarten level nonsense.
As I said, glutathione has many pathways to modulate GABA. I'm not even talking about allopregnenolone and zinc, which goes into the urine in glutathione deficiency and is lost in the zinc finger, which disrupts receptor to dna binding. And that's your cortisol, your androgen receptor, your SOD, etc. Read what is pyroluria, it's basically the same thing.
You're taking complete bullshit and think you're going to cure POIS with this, I'm going to disappoint you. GABA, although it is the cause of POIS, it is just the end stage that causes the symptoms after orgasm. The disruption itself lies downstream and trying to play with GABA is trying to influence the symptoms. People with POIS are sick all the time and without orgasm. So people have their recovery time increase over time and then their POIS can become permanent altogether. It's not about orgasm at all, it's just that the body no longer holds the surge of chemistry that orgasm leads to.
Stop reading stupid studies, open a biochemistry textbook and study the question. And if you want to talk to me, talk in the language of biochemistry, not in the language of silly supplements"
"Good job. Yes, Gilbert's syndrome is one of the causes of POIS. The fact is that with a deficiency of G6PD, the synthesis of NADPH decreases, and the recycling of glutathione decreases. This results in high ROS (NOX) , SOD loss. methylation in this case will be disabled. The Krebs cycle will spend resources (ketoglutarate, isocitrate, malate) on NADPH production rather than NADH, there will be energy loss and additional ROS, because metabolism is faster than energy production. The bile will be thick, SIBO will grow in the small intestine, there will be problems with ammonia and histamine. "