"By the way, dexamethasone blocks cortisol receptors, causing cortisol levels to rise. This significantly reduces the sensitivity of progesterone receptors and also leads to a decrease in intracellular potassium levels. And if, for example, you gradually taper off dexamethasone—just as you would with Clomid—and in the meantime administer zinc and nicotinamide for 3-beta-HSD, then everything will start to unfold exactly as it does with progesterone or Clomid.
This post-progestin cycle is also suitable for treating post-finasteride syndrome. But it won’t be a walk in the park))
And you suffer from respiratory acidosis, since your progesterone receptors are very sensitive. It only takes a little zinc for your intracellular potassium to start fluctuating. (Progesterone raises potassium levels inside cells.) If the receptors are sensitive, potassium rises faster than necessary. The rise in intracellular potassium levels leads to an increase in CO₂ levels, since potassium accelerates metabolism. And there isn’t enough zinc to convert the CO₂ into bicarbonate, because as zinc levels rise, so do progesterone levels—which leads to an even greater increase in potassium levels. That is why, if you take zinc without manganese, respiratory problems can arise due to the high CO₂ level. Even when taking zinc together with manganese, sensitivity still decreases. The body is unable to absorb zinc, since progesterone receptor levels are high and zinc levels remain low. You see, the potassium level inside the cell should actually increase thanks to zinc, since zinc is able to raise the CO₂ level inside the cell and expel it outside the cell.
These methods likely work best for those who have taken steroids such as progestins, Propecia, asthma inhalers, and so on.
If there is a methylation abnormality, but at the same time low dopamine levels, a systemic problem will also arise, since estrogen receptors will be reduced due to prolactin, while progesterone receptors will be increased. That’s why methylation helps, in my opinion. It does the same thing as Clomid and all the other medications, except that, perhaps, it actually treats the person who specifically needs methylation. All other measures may be temporary for these individuals, since, for example, if you have low dopamine levels and have regulated your progesterone receptors with dexamethasone, the effect will fade away after a while anyway.
But the essence of POIS lies in the reduction of progesterone receptors.
Fasting works, too. If you fast, blood sugar drops, cortisol rises sharply, and the body suppresses progesterone receptors to slow down metabolism. The potassium level in the cells drops, and body temperature decreases. Eventually, you take zinc and other supplements. BOOM
No matter how you look at it, you’ll only take zinc in the event of complete failure. And it’s desirable for this failure to last a long time. That is, the longer you delay discontinuing dexamethasone or Clomid, the greater your zinc intake will be. Here, the duration itself and the gradual reduction of the dose are what really matter."
I found this on the Pois Center forum. I wanted to understand why dexamethasone would block the GRs. Doesn't it cause downregulation?
