My history is fairly typical of others except I got this shit from Avodart although I had used propecia in the past too. I first noticed a problem end of December 2016. I had just restarted Avodart and I had done this so many times in the past. Sometimes I would stop because I ran out or just didn't feel like taking it. I never had a problem for ten years. In fact when I restarted Avodart I'd usually notice an boost in libido and maybe even couple pound wt loss. Anyway, I noticed this drop in libido and I remember initially thinking could this be avodart but I actually thought it wasn't because I had been on it so long with no problem. Then about a month later (beginning of Feb) I felt great. Better than average libido and clear thinking no anxiety. Of course that didn't last and by mid February I was struggling! Very anxious, clouded thinking and no libido. Avodart has such a long half life I thought it might get better by April. Of course that didn't happen. I found Propecia help in May and started doing the Progesterone protocol as described by Light at end... So over the past year or so I have had times of feeling almost normal but then had relapses. I think for the most part my anxiety issue is better except having a racing heart rate sometimes before having sex with my wife which doesn't always work, if you know what I mean. This shit has damaged so many lives and I have seriously thought that it could cause a divorce for me. It's so hard to explain to your wife/ partner that you find them attractive and want to be with them and you struggle to get an erection! Not good!!! Anyway, my thoughts are that I think Progesterone may have an important part in the cure for some with PFS. Clearly it doesn't work for everyone and maybe can worsens symptoms for some for unclear reasons. The addition of Ella/RU may help reset something and may augment the effect of Progesterone. Interestingly in May I had been cycling Ella and Progesterone and felt like I was not getting a benefit so I stopped everything in frustration but after the 4 day snap back I was doing so close to prePFS I thought I could be cured! This lasted a good 6+weeks. But unfortunately for some reason symptoms returned. My thoughts (like otheres) are that for some undescribed reason finesteride/avodart damaged the androgen receptor. Progesterone helps paradoxically for some ppl for unclear reasons. My goal is to continue trying different things to try to fix the damaged AR. If finesteride modulated the AR, could there be something that can reset this? I think progesterone and antiprogesterones (RU/ella) can increase AR expression. I think that could be the reason for improvement. So even if they are damaged, if you have more of them maybe some additional signalling can occur. I don't think anyone knows very much about PFS with certainty. I recently tried Anavar. I have higher T and higher level of DHT and adding Testosterone injections could help for like a day, maybe. Taking Arimidex ( small dose) can also help me for like a day. I think both of these maneuvers will increase testosterone but since the AR is damaged, no signficant benefit. I think progesterone/ RU/Ella can help more because of the possible increase in AR expression. Anyway 5 days after Anavar had great libido like prePFS that dropped some but I think I am still above baseline. That trial was clouded as I also took some topical progesterone. This is all just my opinion and I definetly could be wrong.
Trump_1776
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Have we entertained the possibility trying all these drugs is setting back our recoveries?
Do you mean delaying recoveries? I'm sure that is possible but some guys have this for 10 years. I feel compelled to act and do what we can to figure it out and hopefully at some point define a curative regimen. A drug caused this, hopefully a drug/ supplement/ hormone can help fix it. IMO.
Trump_1776
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I see your reasoning. Kinda like you miss all the shots you don't take kinda deal.
Probably a little worse I have noticed more thinning but not horrible. I was only on it for 2 days though.
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Glad I didn’t miss this. @Helen @Boris
Myself and @Jack17 have both benefitted greatly cycling progesterone post RU. And we both have the low end prog in blood. Mine was same as his at 0.2.
I think there are low prog guys post fin and high prog guys post fin. And in the low, Finasteride fills that progesterone pathway rather than progesterone itself. By inflating progesterone on and off, up and down you can fix that pathway.
Don’t get me wrong I think the more precise way of going at it is through digestion, zinc finger, and possible vitamin, mineral ways such as postassium, b1 loading.
Myself and @Jack17 have both benefitted greatly cycling progesterone post RU. And we both have the low end prog in blood. Mine was same as his at 0.2.
I think there are low prog guys post fin and high prog guys post fin. And in the low, Finasteride fills that progesterone pathway rather than progesterone itself. By inflating progesterone on and off, up and down you can fix that pathway.
Don’t get me wrong I think the more precise way of going at it is through digestion, zinc finger, and possible vitamin, mineral ways such as postassium, b1 loading.
This is an update for me and some thoughts. I would prefer only helpful responses. Some back ground on my journey. One year ago after high dose Clomid was discussed, I did that for probably 7 days. Whatever was recommended, is what I did but after several days I had significant genital numbness and less than zero libido so I stopped. After about a week or so, things were great. Strong libido essentially no ED. Had strong dht scalp itch. I think this lasted about one month and then slowly faded away and symptoms came back. I considered that a short term recovery but not a cure of course. I've explained my previous trials with Progesterone and Ella/ RU. I know some say this is not a cure and it hasn't cured me so I don't argue with that but after several cycles by mid May I just stopped. I used to get a little boost in libido and less ED with the regimen and that wasn't happening any more so I just quit. About six days later I felt good. I had stronger libido and very minor Ed. I considered myself 90% recovered. From mid may until mid July I was doing really good. I had two very short relapses for like a weekend and took a half Caber. But otherwise I was good. I make notes on a calender to try to keep track of what I am doing and on July 1st I wrote I am finally 100% better. Well by late July my symptoms were coming back. I took the Anavar as above to for two days but haven't restarted it because I'm not sure about it and kinda waiting for others experience. On other boards I have read PFS occured when someone took Anavar and Propecia. However I am considering taking it maybe once a week. So I have been reading about ppl taking Decadron or methylprednisolone. You can find the stories on Propecia help. Some body was taking it for a week on and then week off. That helped him. Someone admitted to Mayo Clinic and given high dose methylprednisone for five days. I am not proposing anyone taking this. This type of steroid can mess you up. The point is, there are some medical issues were high dose steroid is given in a pulse dose regimen, meaning high dose of one day then wait a week or tow or a month and repeat. It's thought this would not suppress your own system and you wouldn't have the negative side effects. So I am considering this plan. I took 4mg of Decadron yesterday and plan to repeat weekly for several weeks, maybe. I'm not sure this pathway has very been really evaluated ( maybe it has and please no negative comments. We're all in this together to help each other!)
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@Jack17 I rec'd numerous times corticosteroids as one of the pathways, Cytochrome on propeciahelp got cured by them
If GR receptor is upregulated , corticosteroids can downregulate GR receptor.
Nice that you will try this route out.
Finasteride is a progestin, when taken, it kills your own progesterone production to zero. SO body cant get to cortisol. And it has to upregulate GR receptor.
taking dexa might be enough to fix this situation.
If GR receptor is upregulated , corticosteroids can downregulate GR receptor.
Nice that you will try this route out.
Finasteride is a progestin, when taken, it kills your own progesterone production to zero. SO body cant get to cortisol. And it has to upregulate GR receptor.
taking dexa might be enough to fix this situation.
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@Jack17 https://hackstasis.com/threads/accutane-recoveries-using-finasteride.119/page-2#post-1769
@wuf is taking dexamethasone as a part of his ulcerative colitis treatment and we discussed this about 2 weeks ago with him . He said he felt good libido and erections and was tapering,
He was given 60mg so high doses
I hope he responds here and gives us an update
I have 2 other people doing dexa cycles now.
@wuf is taking dexamethasone as a part of his ulcerative colitis treatment and we discussed this about 2 weeks ago with him . He said he felt good libido and erections and was tapering,
He was given 60mg so high doses
I hope he responds here and gives us an update
I have 2 other people doing dexa cycles now.
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The only problem with this dexa , is that all the people who cycled it got really fat))
Cytochrome cycled dexa for a year.
@Jack17 And you are right, I also read that some people got anavar dick. We argued with @Boris about it that it could be because of suppression, but it also could be because of receptor upregulation.
In any case keep us posted about your glucorticoids cycles. I think this route does have merit.
And this is why licorice root helped some people. Since licorice also raised cortisol and downregulated the GR over time.
Be careful with hypokalemia.
Cytochrome cycled dexa for a year.
@Jack17 And you are right, I also read that some people got anavar dick. We argued with @Boris about it that it could be because of suppression, but it also could be because of receptor upregulation.
In any case keep us posted about your glucorticoids cycles. I think this route does have merit.
And this is why licorice root helped some people. Since licorice also raised cortisol and downregulated the GR over time.
Be careful with hypokalemia.
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@Jack17
this route is close to how I got cured. I went on really high dose B1. This increased cortisol like crazy since b1 increases NADPH and downregulated cortisol receptor.
And this then allowed my NADPH to stay up. And got very good androgenic effects. Like I got crazy hair growth everywhere. on my hands arms, body
But B1 and raised cortisol did make me retain a lot of water and I gained like almost 10kg in a month
this route is close to how I got cured. I went on really high dose B1. This increased cortisol like crazy since b1 increases NADPH and downregulated cortisol receptor.
And this then allowed my NADPH to stay up. And got very good androgenic effects. Like I got crazy hair growth everywhere. on my hands arms, body
But B1 and raised cortisol did make me retain a lot of water and I gained like almost 10kg in a month
How much B1 were you taking??
I’ve thought this disease is like a trigger or a switch that occurs. What about taking high dose Vit B1 for couple days a week??
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dexa has half life up to 72 hours. FYI SO if you take 4mg , you will have higher dexa levels end of week then if you take o.5 a day.
But I think it is good to have a nice higher pulse curve like you are doing for receptor downregulation.
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I took really high dose of b1) 2-3 gm a day ) for a week and then went off.