Low Dose Naltrexone Experiences

[IHateFin]

Here is a VERY good paper demonstrating what naltrexone actually does. I uploaded the OP with the link as well. REBOUND = SNAP BACK


Below includes a short excerpt of the paper. I will also include the link for the full paper here.


The mechanism of action of naltrexone, in autoimmune diseases and cancer, is still being researched, but there are theories as to the mechanism of action that both explain why LDN works on both autoimmune diseases and cancers, as well as inflammatory disease. According to Mark J. Donahue’s paper on LDN that uses interviews from Dr. David, Gluck, Dr. Jacquelyn McCandless, Dr. Jarred Younger, and Dr. Ian Zagon: “LDN is an opioid antagonist that not only blocks the reception of opiates, but also the body’s own endogenous opioids – endorphins. However, because LDN is administered in such a 'low dose' it is believed that LDN only briefly (for 3-4 hours) obstructs the effects of endorphins. Sensing an endorphin deficit, the hypothalamus signals for increased production of endorphins in what is called 'the rebound effect.'

The rebound effect results in three things happening:

• Opioid receptor production increases in order to try and capture more endorphins.
• Opioid receptor sensitivity increases, also in order to try and capture more endorphins.
• Production of endorphins is increased in order to compensate for the perceived shortage.

Once LDN is metabolized by the liver and eliminated from the body (after 3-4 hours), the elevated levels of endorphins produced, as a result of the rebound effect, can now interact and bind with the more sensitive and more plentiful opioid receptors. These opioid receptors, are found throughout the body, including virtually every cell of the body’s immune system. The elevated levels of endorphins will usually last around 18-20 hours. During this time the elevated endorphins act by up-regulating vital elements of the body’s immune cells. By doing so clinical trials has been shown that elevated levels of

• Down regulating inflammatory cytokines
• Reducing inflammation and oxidative stress
• Facilitating tissue repair and wound healing
• Restoring T-helper/CD4 levels
• Restoring the balance between Th1 & Th2 lymphocytes
• Increasing cytotoxic T cells and natural killer (NK) cells
• Regulating cell growth & inhibiting tumor growth
• Reducing excitotoxicity and microglial activation
• Reducing apoptosis of the myelin-producing oligodendrocytes
• Stimulating mucosal healing (lining of bowel)” 7

I'm excited!!

 

[tfcjesse]

Has anyone ordered naltrexone to test it out? I like the anti inflammatory and anti cancer perks...

 

[brix]

I’m on day 2 of 1.5mg/day. Will report back in a few days.

 

[IHateFin]

Has anyone ordered naltrexone to test it out? I like the anti inflammatory and anti cancer perks...

I ordered quite a bit. Just made it through customs in the US I'll have it next week

 

[TubZy]

If you try it maybe start at 1mg and go up to 4.5-5mg. See what you feel the best on

 

[IHateFin]

If you try it maybe start at 1mg and go up to 4.5-5mg. See what you feel the best on

I'm probs starting at .5mg or .33mg at first cuz I'm worried about the possible sleep disturbances, but heck yeah my goal is to titrate up to 4.5mg eventually.
I hope it increases 5beta reductase especially whilst taking Randro. That will be interesting

 

[TubZy]

It also goes to show that anything that acts as an opiate agonist can be detrimental to the immune system and testosterone levels. There are already studies on opiates that show that it can lower T levels (oxy, hydrocodone etc.) so it makes total sense doing it in reverse would cause the opposite pathway (i.e. lowering/blocking receptor causing body to produce more endogenous and increase sensitivity). Same goes for the immune system.

Kratom is another opiod agonist, and the biggest complaint is that it can lower your libido (and T levels). Not surprising at all....

 

[MNK99]

Lots of bluelighters (bluelight.org) use LDN to quit and recover from all kinds of things - incl. as you said it opiates. And to repair the pathways.

Despite all its sketchiness, bluelight is the only other main forum I trust. ADDforums, Reddit/ ADD, etc, a bit too. Most are filled w/misinformation.

 

[TubZy]

Has anyone ordered naltrexone to test it out? I like the anti inflammatory and anti cancer perks...

I got mine yesterday, didn't start yet though

 

[IHateFin]

I got mine yesterday, didn't start yet though

when you planning to start?

 

[galio23]

Any natural alternatives ? I am not some anti drug hippie .. i just can not find it in my country.

 

[brix]

I like LDN a lot so far.
Mood has been great.
Libido is at an all time high post fin.
I basically have an erection from the time I pass out until I wake up. Lol.

 

[TubZy]

I like LDN a lot so far.
Mood has been great.
Libido is at an all time high post fin.
I basically have an erection from the time I pass out until I wake up. Lol.

Nice haha. You notice anything else? Increased mood when you work out now (this releases endorphins as well)? Better skin/hair etc?

 

[brix]

Nice haha. You notice anything else? Increased mood when you work out now (this releases endorphins as well)? Better skin/hair etc?

My mood is definitely more positive. Less depressed and anxious.

Hair is still shedding - few in the shower and some on my pillow. It completely stopped until I took Ella and now nothing has stopped it. Copper/calcium/mag worked well for a while but now does nothing.

 

[JDreamer]

I like LDN a lot so far.
Mood has been great.
Libido is at an all time high post fin.
I basically have an erection from the time I pass out until I wake up. Lol.

Just make sure to ditch the sweat pants. LOL

 

[Admiral]

www.buyldn.com

This site sells different dosages, even HCL form. Any suggestion which might be best? Thinking lf going for the 0.5 one myself.

 

[TubZy]

www.buyldn.com

This site sells different dosages, even HCL form. Any suggestion which might be best? Thinking lf going for the 0.5 one myself.

start at 1mg and see how you feel first. Then you can go up. So I would say try 1mg first like an hour before bed

 

[IHateFin]

i just got mine today and i mixed it in the solution and im nervous af lol

 

[IHateFin]

I like LDN a lot so far.
Mood has been great.
Libido is at an all time high post fin.
I basically have an erection from the time I pass out until I wake up. Lol.

are you taking it at night?

 

[IHateFin]

My mood is definitely more positive. Less depressed and anxious.

Hair is still shedding - few in the shower and some on my pillow. It completely stopped until I took Ella and now nothing has stopped it. Copper/calcium/mag worked well for a while but now does nothing.

well technically thats a good sign haha going back prefin usually means hairloss. my scalp is prickly af rn with some shedding.