METHYLATION PROTOCOL

[Helen]

want to point something about this threat.
From Melcangi study, we can read that the issue is the 5 alpha reductase enzyme who is missing in tissue of people.
It is missing in different quantity in liquor brain and other tissues depending from the person who got tested.
So, the issue is not about ARs but about 5alpha reductase enzyme not working properly and that is why we have suppressed DHT metabolites.
This is the issue with pfs, no other bullshit

5ar can be closed because DHT is too sensitive. 5 AR makes DHT.

if you had low 5R you would have low DHT


There is a problem in NADPH system. this is what 5AR works on.




5AR can be closed on purpose in some cases. or you can have low OR HIGH NADPH production and thus 5AR will not work and this creates oxidative stress

 

[ruprmurdoch]

you need to understand that 23 and me mutuations are just adaptation.

since I and other have seen mutation change after TEI and ARL programs. just FYI.

Helen is right. Genes can be modified (coded) just by excersising/eating certain/routine diet/enviroment. People think like Protestants that everything is set. No it's not. Most of things are UP TO YOU. This is Epigenetics.

 

[wuf]

5ar can be closed because DHT is too sensitive. 5 AR makes DHT.

if you had low 5R you would have low DHT


There is a problem in NADPH system. this is what 5AR works on.




5AR can be closed on purpose in some cases. or you can have low OR HIGH NADPH production and thus 5AR will not work and this creates oxidative stress

I fact from melcangi study we all have low DHT in the brain.
5 alpha reductase has been shut down in tissue where it is present. Mainly brain and penis, but we can see we have dht in blood but not in cerebral spinal liquor.
That means that blood is different from cerebral spinal liquor and 5 alpha had been shut down mostly in the brain where we can see Zero DHT IN PEOPLE WHO got tested in melcangi study.
So to reply your previous post, yes we don't have dht at all!!
And you also commented this about my results in melcangi tests, so you know we miss dht in the brain... Miss would be fine, the problem is that dht in the brain is ZERO

 

[Helen]

@wuf you need to understand that we know that 5AR is closed. I wrote about it many times.

we are talking about the possible reasons why

 

[wuf]

@wuf you need to understand that we know that 5AR is closed. I wrote about it many times.

we are talking about the possible reasons why

Does this make sense to try to activate NADPH again?
From a pharmacological point of view, G6PDH is inhibited in a non-competitive and fairly specific manner by the steroid dehydroepiandrosterone and its halogenated derivatives. The vanadate anion, on the other hand, inhibits the enzyme competitively. The drug metformin used in the treatment of type II diabetes is able to activate the enzyme in a way that has not yet been discovered; however, it could represent a positive secondary effect given that the pentose phosphate pathway produces NADPH which regenerates glutathione, a natural antioxidant that is lowered in diabetics.

This study says that metformin can rise NADPH.Is this a way to try?

 

[wuf]

@wuf you need to understand that we know that 5AR is closed. I wrote about it many times.

we are talking about the possible reasons why

Plus.. Is there a way to test NADPH?
I will try to search in internet, if anyone find a way to test, let's test it and we know.

 

[Helen]

Does this make sense to try to activate NADPH again?
From a pharmacological point of view, G6PDH is inhibited in a non-competitive and fairly specific manner by the steroid dehydroepiandrosterone and its halogenated derivatives. The vanadate anion, on the other hand, inhibits the enzyme competitively. The drug metformin used in the treatment of type II diabetes is able to activate the enzyme in a way that has not yet been discovered; however, it could represent a positive secondary effect given that the pentose phosphate pathway produces NADPH which regenerates glutathione, a natural antioxidant that is lowered in diabetics.

This study says that metformin can rise NADPH.Is this a way to try?

In PFS NADPH could be high or low. as I already told you.


NADPH oxidase could be also high in some people which creates oxidative stress.

 

[Helen]

In PFS NADPH could be high or low. as I already told you.


NADPH oxidase could be also high in some people which creates oxidative stress.

Wuf in your case you have zero 3 alpha HSD. your DHT does not convert further into its metabolites.


If DHT does not convert into its metabolite 3 adiol. it could be why your 5AR is closed.


3 beta adiol is also low, so that means your progesterone is low. not high.


is your progesterone low? in blood?

 

[wuf]

Wuf in your case you have zero 3 alpha HSD. your DHT does not convert further into its metabolites.


If DHT does not convert into its metabolite 3 adiol. it could be why your 5AR is closed.


3 beta adiol is also low, so that means your progesterone is low. not high.

And so, what to do?
TEI?

 

[Helen]

And so, what to do?
TEI?

answer my question from previous post.

 

[wuf]

answer my question from previous post.

FT3 2.5 pg/ml...... . 1.8_4.5
FT 4 11.1 pg/ml...... 9.2_17.00
Prolattin 9.6 ng/ml...... 4_15.2
Testosterone total 5.21ng/ml...... 2.8_11
Free testosterone 17.2 pg/ml.... 20.8_64 LOW
Estradiol 19pg/ml.....13.5_59.5
Progesterone <0.05..... <0.15
Androstenedione 0.8ng/ml......0.45_4.2
TSH 1.05 microU/ml..... 0.270_4.200
ACTH 42.1 pg/ml..... 7.2_63.3

 

[wuf]

answer my question from previous post.

low progesterone.

 

[Helen]

low progesterone.

what did Melcangi measure your testosterone levels with in plasma? LOL


your free test is low. not high.

None of the tests that he did match what people did on propeciahelp and it does not even match what you did in your blood.))

 

[wuf]

what did Melcangi measure your testosterone levels with in plasma? LOL


your free test is low. not high.

None of the tests that he did match what people did on propeciahelp

These are my last results I just took 2 weeks ago.
This is blood test I just took from hospital.

 

[Helen]

These are my last results I just took 20 weeks ago.
This is blood test I just took from hospital.

it does not match what Melcangi tested in you.

 

[wuf]

it does not match what Melcangi tested in you.

I had a different situation when melcangi tested me.
It was 3 years ago... Then I crashed with androstenolome prohormones, then I used HC so my situation has probably changed..
This is blood but I am sure in brain my dht is still the same Zero

 

[wuf]

what did Melcangi measure your testosterone levels with in plasma? LOL


your free test is low. not high.

None of the tests that he did match what people did on propeciahelp and it does not even match what you did in your blood.))

So, melcangi study has no sense in your opinion?
Or the tests he made are just weird?

 

[Helen]

So, melcangi study has no sense in your opinion?
Or the tests he made are just weird?

tests that he did dont match when people with PFS test themselves.

Thus it is very hard to go by his tests.

that is why I asked people to test free DHT. just to make sure it is the same.


but in your case. you seem to have low 3a hsd. and and 3 beta hsd according to his tests.

 

[wuf]

tests that he did dont match when people with PFS test themselves.

Thus it is very hard to go by his tests.

that is why I asked people to test free DHT. just to make sure it is the same.

Can you please provide a list of main things to test so who wants can go to test that list?
I would really like to be tested the most I can, and if a lot of us do, we can have some real data.
For example free dht, acid folic, etc..
By the way, you ask to test free dht, by blood, but are we sure that is the same we have in brain ln liquor

 

[wuf]

Here is the way to test g6pd deficiency that would mean ALSO NADP deficiency Hhttps://path.org/resources/guide-fluorescent-spot-testing-g6pd-deficiency/