Minoxidil Acts as an Antiandrogen: A Study of 5α-reductase Type 2 Gene Expression

[M_Mitchell08]

Minoxidil increases 17 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase activity of cultured human dermal papilla cells from balding scalp. - PubMed - NCBI min increases 17 beta hsd(40%) so i wonder what effect that would have if it goes systemic

Interesting that it talks about 5AR up-ticking too.

 

[D4n]

@M_Mitchell08 I think there is initial 5ar increase followed by Downregulation same with 17beta maybe

 

[M_Mitchell08]

What is the link to 17beta and hairloss?

@M_Mitchell08 I think there is initial 5ar increase followed by Downregulation same with 17beta maybe

 

[D4n]

Not sure think it effects hormone conversions 17β-Hydroxysteroid dehydrogenase - Wikipedia seen Helen mention it in another thread

 

[Helen]

NO will always cause upregulation of androgens. but since MInoxidile is NO> it is a duaretic. and in the end since you dont produce your own NO. this will cause downregulationsof all these enzymes. which use NADPH. I would assume


17 beta hsd works on NADPH. Nitric oxide is made with NADPH. Minoxil is NO.

 

[snowball]

Interesting, I had the same experience on Ella. Libido went a bit higher the minute I took Ella but it never stuck. I think there is some missing link why it does not stuck, potassium or prolactin related maybe.

Similar experience with Ella so far

 

[D4n]

Minox effects the AR and glucocorticoid systems according to studies. Anavar upregulates both of these. May be the next step for me to try

 

[Helen]

Minox effects the AR and glucocorticoid systems according to studies. Anavar upregulates both of these. May be the next step for me to try

I like anavar since it blocks DHT and upregulates zinc finger. but we never tried it yet. We have discussed it.

 

[D4n]

I like anavar since it blocks DHT and upregulates zinc finger. but we never tried it yet. We have discussed it.

I’m thinking about it, since I only need to recover libido. Also I tried high dose b1 the other day seems to greatly reduce anxiety for me

 

[Helen]

I’m thinking about it, since I only need to recover libido. Also I tried high dose b1 the other day seems to greatly reduce anxiety for me

that would be nice if you were to try it. People talk about it all the time, but no one tries

 

[tonysoprano]

I’m thinking about it, since I only need to recover libido. Also I tried high dose b1 the other day seems to greatly reduce anxiety for me

Same here with the anxiety related to b1

 

[D4n]

that would be nice if you were to try it. People talk about it all the time, but no one tries

Yeah I’m a bit worried about it causing suppression and getting a legit source. may be fine though

 

[D4n]

@BeLikeWater have you tried var yet ?

 

[Helen]

Yeah I’m a bit worried about it causing suppression and getting a legit source. may be fine though

Read this post

 

[D4n]

Read this post

have you got a link lol

 

[Helen]

have you got a link lol

sorry LOL https://hackstasis.com/threads/hopeforrecovery-log.1042/

 

[ruprmurdoch]

1.acetazolamide- Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea


Acetazolamide - DrugBank

2.The hair-loss treatment minoxidil and the anthelminticsalbendazole, flubendazole, and mebendazole feature 2-aminoimidazole substructures derived from cyanamide.[3]

Cyanamide - Wikipedia

 

[Helen]

1.acetazolamide- Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea


Acetazolamide - DrugBank

2.The hair-loss treatment minoxidil and the anthelminticsalbendazole, flubendazole, and mebendazole feature 2-aminoimidazole substructures derived from cyanamide.[3]

Cyanamide - Wikipedia

Yes, I suggested Ace in several threads and we used it. read https://hackstasis.com/threads/pssd-proposed-solution.205/

 

[Jaxx]

Yes, I suggested Ace in several threads and we used it. read https://hackstasis.com/threads/pssd-proposed-solution.205/

Didnt see clear results in the few people that tried it, was it tried in a proper manner you think?
It's a pain to get so i get there are only a few here.

 

[Helen]

Didnt see clear results in the few people that tried it, was it tried in a proper manner you think?
It's a pain to get so i get there are only a few here.

people on this forum seem to try stuff that does not work. for some reason no one tries what actually works. We have many recoveries already and all of them did the same thing. slow oxidizer Raincost. check his logs, and faster oxidizer scenes and rwac.

Plus ace treatment, plus progesterone cycling, plus testosterone plus progesterone. plus vitex and pine pollen.

by the way i found that carnosine is MAOB inhibitor. Have you tried that before. Once I used 3 grams a day , I had copper coming out so much from my brain that I was getting anemic. MY hands were all in copper.

Just imagine how much of that stuff we can have in our brains.

And now think depression. How that copper just kills serotonin there.


I think raincoast protocol is valid for PSSD people. I think I will try it with talkigand or barbaar soon. I think it will def work.

All other boostin dopaming receptors, etc. I think is temporary solution. You guys were sick before SSRI, so you cant live in that state. you need to get fixed.

TEI and ARL do it slowly. My program that i gave Raincoast does it fast. Especially if we can add extra Bs to it.