@bruschi11 @TubZy @Niles @Troy @noprop
Guys PFS is the condition where there is no nitric oxide. Arginine is broken down by arginase. This is done because the body cant handle NO, production of NO makes lot of superoxide / same as sugar metabolism. This is why sugar mebolism and NO = run parallel.
NO is made with
iron plus FAD plus NADPH, plus bh4. this gets your nitric oxide. This creates superoxide. So creations of nitric oxide, requires SOD to handle superoxide. SOD contains manganese zinc copper histidine aspartate. then the product of the SOD is hydrogen peroxide, and for that you need seleno cysteine enzyme glutathione peroxidase.
SO anyone who is trying to cure PFS should look into from the back to forward. and support these enzyme.
Aspartate in the body is made from malate enzymes. But as we know that malate enzymes are used up a lot to make NADPH when penthose pathway is down .
So basically, people can have problems in any of these FAD, NADPH, BH4 recycling, and SOD systems, glutathione peroxidase
Since we know that in PFS sugar metabolism is closed.( sorry MARIO this was posted like 8 years ago)) by TONS of people including Ray Peat.
When the body cant make NO, it does not have anything to do with arginine. So it has to stop its production and increase its breakage.
it does this with arginase and by stopping enzymes that make cirtrulline from ornitine. the enzymes that make citrulline from ornitine are on zinc and biotin. This is why we see high levels of zinc in the urine biotin and b6. Which is basically pyroluria treatment
Now our goal is to have b6 biotin and zinc working again. Since they will make arginine and this will make nitric oxide.
How do we do that. We provide the components above to make NITRIC oxide, and also we need to look at components further down the line, which provide SODS and glutathione peroxidase. since if those components are missing , then we cant make nitric oxide and cant open up sugar metabolism.
Same exact enzymes are needed to allow sugar metabolism. B1 is needed to use sugar, then SOD is needed to deal with superoxide, and then glutathione peroxidase is needed to handle the hydrogen peroxide.
YOu see that sugar metabolism goes hand and hand with NO metabolism. SO no sugar metabolism no NO metabolism
This is why PFS people feel bad on sugar. coffee, anything that kills B1.
So now we have to basically try all combinations of these things to cure people one by one.
For some it could be just B1 deficiency, then you take B1 and then you take all the minerals that B1 made you lose, like zinc biotin , b6 , etc.
Since B1 deficiency stopped those minrerals from working and you pissed those into the urine.
Second case is that B1 deficiency is since B1 is not working and this causes all those other minerals to be lost also. but it happens since B1 cant b e allowed since either SODs are missing zinc copper manganese histdine aspartate. or glutathione peroxidase is missing which is selenium cysteine. or it could be that b2 is missing along with magnesium.
SO basically all treatments will be from this list. If you look at ARL and TEI , all their stuff is from this.
But may be the levels of certains vitamins are too low.
All the bile acids deficiencies, stem from low NADPH FAD system since all bile acids are made with these and these recycle glutathione which recycles vitamin C and E and those make your bile acids , ascrobate is the cofactor to make bile acids,
When you start making bile acids, you will have all fat soluble vitamins, and you cat eat butter for them.
So lets chose people and try all these routes.
IT is basically electrolytes protocol. but may be we can try different combinations. Lets have 2-3 people and try these. with me
Also these conditions could have low or high fibrinogen levels
https://hackstasis.com/threads/high-or-low-fibrinogen-levels-pfs-cfs-me-pssd-pois.1034/
