Post Accutane - Oily skin

[Helen]

Many thanks, got it all, and found the post from @Jamie asked how much methionine he tested with as well.

I am sure it will work for you

 

[Orion]

I am sure it will work for you

methionine should arrive on wednesday, stopping everything until I have it. Will start up the stack with it, and play with Zn/Mang, will keep this thread updated.


After the Breuss fast, skin is still the best ever, best lean shape ever, so I only have my thanks to offer you @gbolduev if my hair comes back online this year along with good skin, you have saved me!

All the best to you in 2018!

 

[Jamie]

I am taking 0,5g twice a day.

 

[Orion]

I am taking 0,5g twice a day.

Thanks, still seeing the good benefits?

 

[Jamie]

Thanks, still seeing the good benefits?

I see most benefits in the term of my high undermethylation. I don't have diarrhea 4 times a day, but normal 1-2 bovel a day. In the future I will make a bigger log and describe it briefly but for now I want to see if it sticks in long run.

 

[Orion]

Renamed so it makes more sense: "Post Accutane - Oily skin - Methionine, Cu, K, Mag, Mang, Se, and Zn testing"

Interested also in seeing if it will have an affect on my tinnitus, never had issues until I did aspirin, now it won't go away, gbolduev mentioned manganese as possible treatment for this in shadows log.

I think I gave you the right protocol . May be lower a little copper in it. to 2 mg and have zinc at 15/

 

[Orion]

Methionine arrived today, so starting the oily skin and shedding post accutane protocol experiment:

4mg Mn, 1-2mg Cu, 300mg Mg, 500mg K, 100mg Se, 200-300IU Vit D and 500mg methionine and then add ~10-15mg Zn

Taking some B1/2/3, very small doses, with 1teaspoon brewers yeast. Also using 650mg Betaine HCl dissolved in water after meals.

@gbolduev would taking glycine, lysine and Vit C be beneficial with this stack?

Also found and old blood test(2010 - post accutane), showing that I had very high ferritin(500), but have donated blood many times since then.

 

[Aleksandr]

Methionine arrived today, so starting the oily skin and shedding post accutane protocol experiment:

4mg Mn, 1-2mg Cu, 300mg Mg, 500mg K, 100mg Se, 200-300IU Vit D and 500mg methionine and then add ~10-15mg Zn

Taking some B1/2/3, very small doses, with 1teaspoon brewers yeast. Also using 650mg Betaine HCl dissolved in water after meals.

@gbolduev would taking glycine, lysine and Vit C be beneficial with this stack?

Also found and old blood test(2010 - post accutane), showing that I had very high ferritin(500), but have donated blood many times since then.

Is that enough potassium to see an effect? RDIs are like 4500-5000mg. Dunno what the rest of your diet looks like. But i get 1500mg potassium in the tomato paste i put with dinner. Youd probably get more than 500 eating one potato.

 

[Orion]

Is that enough potassium to see an effect? RDIs are like 4500-5000mg. Dunno what the rest of your diet looks like. But i get 1500mg potassium in the tomato paste i put with dinner. Youd probably get more than 500 eating one potato.

Getting lots of K from diet, that 500mg is from KCl just to top off.

 

[Orion]

Started the protocol Monday, did it for two days, and know I should commit longer, but just not feeling well on Copper plus stack.

Digestion worsening, sleep is not good(hot sweaty, lots of waking, not deep), shedding and sebum seems to increase on Cu.

New plan; stopping all supplements, and will do hairtest/bloodwork in the next weeks to see where I am at and move forward. Chronometer is showing that I hit way above all the macros/micros, so hopefully even though their reported values are nominally off, I am getting everything I need.

Long Breuss fast fixed my body comp, dandruff and acne(my major issue), now only dealing with minor oily skin on face/scalp and continued shedding.

GHK-Cu could be the way forward, as hair shedding is viable thick hairs with bulb attached(connective tissue related), but will wait until I have new hair and blood test.

 

[Aleksandr]

Started the protocol Monday, did it for two days, and know I should commit longer, but just not feeling well on Copper plus stack.

Digestion worsening, sleep is not good(hot sweaty, lots of waking, not deep), shedding and sebum seems to increase on Cu.

New plan; stopping all supplements, and will do hairtest/bloodwork in the next weeks to see where I am at and move forward. Chronometer is showing that I hit way above all the macros/micros, so hopefully even though their reported values are nominally off, I am getting everything I need.

Long Breuss fast fixed my body comp, dandruff and acne(my major issue), now only dealing with minor oily skin on face/scalp and continued shedding.

GHK-Cu could be the way forward, as hair shedding is viable thick hairs with bulb attached(connective tissue related), but will wait until I have new hair and blood test.

Yeah im convinced now we should just get out minerals from a good well rounded cronometer diet. I must have been chronically deficient in potassium among other minerals for my whole life the way ive been eating! No wonder my hair test was less than ideal.

Maybe amino acids can jumpstart the digestive process too, but it still seems speculative at this point.

 

[Orion]

Maybe amino acids can jumpstart the digestive process too, but it still seems speculative at this point.

Yeah @gbolduev has mentioned that histidine can be the limiting amino, since stomach acid production is tied to it. So its a catch-22, low stomach acid from low histidine, low histidine from low stomach acid = low *all* types aminos being absorbed.

I think Betaine or @mattyb morning greens/OO/malic acid approach might be useful, with proper chronometer intake monitored to hit above daily values.

 

[Orion]

So I have never taken Benadryl before, tested 25mg last night. It did not help me sleep longer, deeper or reduce overnight nostril congestion, but did reduce sebum production overnight. Skin much drier this morning, along with dry eyes. So there is some histamine/sebum connection for sure with me.

Identification of histamine receptors and reduction of squalene levels by an antihistamine in sebocytes


@mattyb thoughts on long term low dose anti-histamine use? I think I might use 25mg once or twice a week to tone down the sebum output...

 

[mattyb]

It's not necessarily histamine. Benadryl is antimuscarinic. That's what causes the dryness.

Cyproheptadine is the best antihistamine with antimuscarinic properties to take. Safest to take long term and the doses you need for it are way smaller than other antihistamines. It dries out my scalp at 1-2mg per day. No known long term complications either.

It will affect copper and zinc metabolism though by upregulation of CuZnSOD. I had to supp with low dose zinc during it otherwise my ejaculate volume went down. But I was taking it every day.

 

[Orion]

It's not necessarily histamine. Benadryl is antimuscarinic. That's what causes the dryness.

Cyproheptadine is the best antihistamine with antimuscarinic properties to take. Safest to take long term and the doses you need for it are way smaller than other antihistamines. It dries out my scalp at 1-2mg per day. No known long term complications either.

It will affect copper and zinc metabolism though by upregulation of CuZnSOD. I had to supp with low dose zinc during it otherwise my ejaculate volume went down. But I was taking it every day.

Strange, cypro didn't have the same affect on my skin, tested with it many times in the past, and it knocks me out, 1mg makes me non-functional the next day. I will test with it again maybe, but ya it makes it so I can barely get up out of bed or off the couch...

Thanks for the extra Zn info.

 

[mattyb]

Yeah cypro is a much stronger sedative, I often only took 0.5mg when I took it. It's a safer option for long term use IMO than benadryl, but if benadryl is what works best for your skin I don't see any serious problems occurring with taking it 1-2 times per week. As long as you can get the same effects while keeping the dose as low as possible and there's not any counter-regulation that occurs over the long run it should be okay.

 

[Orion]

It's not necessarily histamine. Benadryl is antimuscarinic. That's what causes the dryness.

Are there ways naturally through diet/food to produce a antimuscarinic effect that is not detrimental? and skip the bena/cypro?

Muscarinic antagonists look more like its all drug based.

 

[Orion]

Experimented with copper 3 weeks ago on Dec 27th, took 1mg/day for 6 days total, and it brought on heavy night sweats immediately the first night.

Still haven't been able to get a nights sleep with out some type of night sweat waking event, which usually happens early, about 2-3hrs after I fall asleep. It has been waning somewhat, but would like to figure out how to make it go away.

Anyone solved night sweats?

 

[Orion]

Anyone solved night sweats?

So 25mg Zinc and 50-100IU Haiduts tocovit finally stopped the night sweats in one day.

I guess the 6mg's I took of isolated Cu over a week, was not opposed by my daily Zn amounts from food intake. Cu/Estrogen opposed related somehow?

Glad to have solved this, night sweats are annoying and f&$king gross!

 

[Aleksandr]

So 25mg Zinc and 50-100IU Haiduts tocovit finally stopped the night sweats in one day.

I guess the 6mg's I took of isolated Cu over a week, was not opposed by my daily Zn amounts from food intake. Cu/Estrogen opposed related somehow?

Glad to have solved this, night sweats are annoying and f&$king gross!

Have you retested your hair?
I could imagine a fast would lower a lot of your minerals (putting you into fast oxidation), zinc is supposed to be great for raising calcium, magnesium and potassium. It could be a balance thing. Copper raises sodium (but this can give you overactive adrenals)