POTENTIAL explanation for PFS.

[Helen]

@Walker http://www.latamjpharm.org/resumenes/36/12/LAJOP_36_12_1_28.pdf

This is why you got PFS , I think

 

[diffi]

Ver

@Walker http://www.latamjpharm.org/resumenes/36/12/LAJOP_36_12_1_28.pdf

This is why you got PFS , I think

Very intetesting! Does this explain pfs induced by nsaids?
Would adressing the liver a helpful way?
I heard that intermittent fasting could restore broken/destroyed enzymes?

 

[Walker]

@Walker http://www.latamjpharm.org/resumenes/36/12/LAJOP_36_12_1_28.pdf

This is why you got PFS , I think

Interesting. Never seen a real strong link/explanation for the two before, but I figured there had to be some form of one.

Not going to lie, this is way over my head or understanding lol.

 

[argentino1984]

how 3a-adiol into 3a-adiol G conversion can be induced

 

[Admiral]

So Dr Powers’ theory is pretty much what Helen mentioned in this specific thread. His theory as of why pfs happens is pretty much a given now. Finding the cure is his next goal. The chemical castration seems to have worked, but time and some adjustment is needed.

In the meantime, Helen’s ideas (and Talkedout’s) posted in this thread should definitely gain way more attention now.

 

[RebelWithACause]

Yes, it does make sense. Also what Helen says about finasteride not being metabolized out. I had years of low DHT after stopping finasteride. Until I didn't anymore after doing a bunch of protocols and I was back in my old situation. Which was also flawed. In some ways it was better in PFS certain things. Except for the insane anxiety and lack of emotions/libido/ability to connect. I was more levelheaded even with the anxiety. Once I got out of PFS I became more like my old self I got angry faster and even my old depression came back. PFS I was depressed for other reasons. Out of PFS I had that old hopelessness depression and nothing matters.

Now much better. I think Helen also said this as well that sometimes you will just get worse when you get out of PFS. You just go back to your old health status.

 

[MNK99]

exactly what i told pedro @Pedro melo that it inhibits its own metabolism and or its not depleted, still actively metabolized in ways.

fine maybe for test or anavar... but ya that's terrible for a terrible drug. a castration/ pseudohermamphrodite derived drug.
almost killed many of us, imagine what that and trans drugs do to kids (but all cool by the bill gates medical types, and mostly just dumb followers).

hence just proviron or any singular treatment isn't a singular cure.

and why fasting for ppl like me. carnivore or whatever meat and cooked veg and TEI (after and around actual drugs).
and the actual pathways are broken along whatever 40 possible chains, as per that image Walker posted on discord a couple yrs ago.

Who is Talkedout btw?

 

[Admiral]

Thinking about how to increase UGT activity, particularly UGT2B15 and 2B17, as those metabolize androgens most heavily.

• UGT enzymes use UDP-glucuronic acid to attach it's glucuronic acid to another compound, like an androgen
  • UDP-glucuronic acid is made by enzyme UDP-glucose 6-dehydrogenase from UDP-glucose and NAD+
    • How to boost NAD+
    • UDP-glucose is synthesized from glucose 1-phosphate and uridine triphosphate (UTP) in a reaction catalyzed by UDP-glucose pyrophosphorylase
      • Glucose 1-phosphate is made with glucose and ATP
        • L-cartinine increases glucose uptake
        • Some CoQ10 supplements were tested to increase ATP synthesis. Here is one but it's expensive.

So here is my guess at a protocol to increase UGT enzyme activity, by providing substrates:

• Sufficient carbs in diet for glucose
• L-cartinine for glucose uptake
• NADH and CoQ10 for ATP
• Uridine for UDP-glucose
• Nicotinamide Riboside for NAD+

Also, avoid this for more UGT activity:
Green and white teas suppress UDP-glucuronosyltransferase UGT2B17 mediated testosterone glucuronidation

Talkingant I mean. Sorry!

This post barely got any attention, because Helen was sprouting ideas and protocols back then. Such a shame!

Anyway, he comes up with a protocol. I think these days, with the help of AI such as Claud Science, we could come up with an even better protocol.

I really feel there’s an answer here. Hope more chime in.

 

[bruschi11]

I mean it’s pretty simple. Correcting metabolic function at its core ends up being the most simple solution after looking at talkingant’s stuff.

Hence why mineral balancing works for simple cases. Then the sicker people have to focus on glucagon insulin glycogen stuff a more diabetes type mindset. Hormone
Metabolism specifically.

Seeing what I see in those posts gives me more confidence I’m working on exactly what I should be.