RebelWithACause
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Trump_1776
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About 500mg, I just eyeball it.
Another update, after reading more about the glutathione/NO relationship, I took relatively high folate + folic + arginine and had RAGING boners. Like this morning I could not get my wood to go away after hanging out with my girl. Literal hours of hard pre-drug boners. Good signs my dudes
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@Rid In PFS in some people glutathione reductase is DOWN.( which is run on B1, b2)
This is why CYSTEINE is used up to produce glutathione DE NOVO. Instead of glutathione reductase recylcing it.
This is what electrolytes protocol was all about to restore glutathione recylcling so the body stops taking cysteine and making new gluthathione out of it.
This is why without b1 and b2 you cant make folate.
bodu closes down folate cycle. since it needs homocysteine to go into cysteine to make glutathione de novo.
And if you had glutathione reclycling, then it would not need cysteine . and it will use zinc to recycle homocysteine back to methionine and increase methylation and methylfolate
Basically when you have no glutathion recycling, the body stop methylation cycle to make glutathione.
And this undermethylates some genes.
More read for you. Hackstasis Wiki
Glad you are turning the corner. to restore and keep restoring glutathione recycling you need to stay on this for a while.
Histidine is lost into the urine, when folic acid is low. Since folic acid is needed to metabolize histidine.
Thus if you take folate. histidine is stopped from being wasted into the urine and goes up in blood.
Finasteride fucks up NADPH. NADPH( b1) is what glutathione reductase is RUN on, along with FADH.( b2)
So now your glutathione is not being recycled. and the body just has to make NEW glutathione all the time. so it spends Cysteine like crazy, and glycine, glutamate
Without NADPH and FADH, you cant make methylfolate.( research this) And if there is no methylfolate, body has to take histidine, and put it into the urine.
Since methylfolate or tetrafolate are needed to convert histidine into glutamic acid
Since glutathione reductase is down, your ferrochelatase goes down, And this give you problems of inserting iron into heme.
And this causes a condition called PYROLURIA
Zinc goes into the urine since methionine synthase is zinc enzyme, and body wants to keep homocysteine high for cysteine.
and b6 stays not active, since there is no b2 to activate it. Many people take zinc plus active b6 in this condition, where the real problem is ferrochelatase enzyme and TET which use iron, and TET demethylates some genes. and when iron is missing in usable form, because of lack of glutathione reductase then there is no demethylation or NO, or methylation. and iron can actually accumulate and precipitate.
And thus we have hypo and overmethylation of some genes in PFS and PSSD etc
I hope this makes sense to you.
This is why CYSTEINE is used up to produce glutathione DE NOVO. Instead of glutathione reductase recylcing it.
This is what electrolytes protocol was all about to restore glutathione recylcling so the body stops taking cysteine and making new gluthathione out of it.
This is why without b1 and b2 you cant make folate.
bodu closes down folate cycle. since it needs homocysteine to go into cysteine to make glutathione de novo.
And if you had glutathione reclycling, then it would not need cysteine . and it will use zinc to recycle homocysteine back to methionine and increase methylation and methylfolate
Basically when you have no glutathion recycling, the body stop methylation cycle to make glutathione.
And this undermethylates some genes.
More read for you. Hackstasis Wiki
Glad you are turning the corner. to restore and keep restoring glutathione recycling you need to stay on this for a while.
Histidine is lost into the urine, when folic acid is low. Since folic acid is needed to metabolize histidine.
Thus if you take folate. histidine is stopped from being wasted into the urine and goes up in blood.
Finasteride fucks up NADPH. NADPH( b1) is what glutathione reductase is RUN on, along with FADH.( b2)
So now your glutathione is not being recycled. and the body just has to make NEW glutathione all the time. so it spends Cysteine like crazy, and glycine, glutamate
Without NADPH and FADH, you cant make methylfolate.( research this) And if there is no methylfolate, body has to take histidine, and put it into the urine.
Since methylfolate or tetrafolate are needed to convert histidine into glutamic acid
Since glutathione reductase is down, your ferrochelatase goes down, And this give you problems of inserting iron into heme.
And this causes a condition called PYROLURIA
Zinc goes into the urine since methionine synthase is zinc enzyme, and body wants to keep homocysteine high for cysteine.
and b6 stays not active, since there is no b2 to activate it. Many people take zinc plus active b6 in this condition, where the real problem is ferrochelatase enzyme and TET which use iron, and TET demethylates some genes. and when iron is missing in usable form, because of lack of glutathione reductase then there is no demethylation or NO, or methylation. and iron can actually accumulate and precipitate.
And thus we have hypo and overmethylation of some genes in PFS and PSSD etc
I hope this makes sense to you.
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Trump_1776
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Yeah dude total sense lol jesus fucking christ
Trump_1776
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Basically cysteine and histidine will be fine right?
Trump_1776
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Why no histidine in NO protocol?
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what are you talking about. there is histidine. Look at what Orion is taking
Nitric oxide protocol is a castrated version of electrolytes protocol
Usually when you feed methylfolate histidine goes up on its own.
but electrolytes protocol has all of those.
Trump_1776
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I see, the folate raises histidine itself. I didn't see histidine exclusively on the wiki.
So its recommended to take folate instead of histidine basically?
just wanted to give a quick update. I've been continuing with 500mg+ of cysteine, arginine, b supplement and along with a healthy routine i'm feeling pretty fuckin good. my results with cyst started to taper off, I bumped up the dosage to maybe 600-750mg from ~500 and I'm responding very well again. great energy, skin looks great, able to sleep 8 hours with no issue, sexual health is good. only issue is my hair seems to be falling out like crazy. I guess I should appreciate that... but it's funny how one problem takes over the other. it's all relative.
I have some labs I'll post probably tomorrow. hormones were all over the place for a while but it'll be interesting to compare and contrast with other saw palm and pssd people who seem to have a similar profile as me. hope you all are kickin ass, keep it up boys!
I have some labs I'll post probably tomorrow. hormones were all over the place for a while but it'll be interesting to compare and contrast with other saw palm and pssd people who seem to have a similar profile as me. hope you all are kickin ass, keep it up boys!
BeLikeWater
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Guys when you say low potassium is in blood or in cells?
update:
hey, I've been pretty good, which is nice to report. sexual health has been up and down a lot, some weeks I'll have higher libido consistently with higher sensitivity/EQ, and then other times that drive and sexual health just aren't there.
I noticed after taking a single, low dose of trib, my EQ and drive have dropped dramatically. Feel pretty shit, even managed to get sick, which is quite rare for PFS it seems. definitely histamine/immune related. I remember @Helen mentioning that hist/cyst and tribulus don't work well together because of their interactions on AR. sort of cancel each other out if I remember correctly? Still taking occasional NAC/histidine and playing with things occasionally. feels good to have a good balance back in my system.
I've been interested in microdosing saw palmetto, which got me in this situation, similarly to @Jack17. it's always made sense to me that a lot of our issues were related to sensitization, and that my up and down swings directly relate to this. I very distinctly remember being the horniest in my life after stopping saw palmetto the first time, before getting to a PFS baseline of low libido and not great sexual health. I remember reading many stories of people essentially tapering off the right way after getting sides, and I feel healthy enough to try something. obviously this is dangerous and we have read reports of this going both ways, but I feel ready to do a little experimenting. I know I usually snap-back pretty well to very, very light AR-inhibs. Recently I remember reading about milk thistle having ARI properties, and feeling really good on that. Again, hair of the dog kind of situation. Feeling bold enough to try low dose saw-p finally.
Otherwise, it is good to note that all of my other symptoms, classic PFS mental/physical sides, have mostly subsided. I still don't have the drive in life I used to, but I think that might be partly mental. this whole experience chilled me out a good bit, and i'm so thankful I don't have the crippling anxiety and depression I had for a solid 1-2 years like at the beginning of this journey. Just need my sexual health back and I'll be good.
hey, I've been pretty good, which is nice to report. sexual health has been up and down a lot, some weeks I'll have higher libido consistently with higher sensitivity/EQ, and then other times that drive and sexual health just aren't there.
I noticed after taking a single, low dose of trib, my EQ and drive have dropped dramatically. Feel pretty shit, even managed to get sick, which is quite rare for PFS it seems. definitely histamine/immune related. I remember @Helen mentioning that hist/cyst and tribulus don't work well together because of their interactions on AR. sort of cancel each other out if I remember correctly? Still taking occasional NAC/histidine and playing with things occasionally. feels good to have a good balance back in my system.
I've been interested in microdosing saw palmetto, which got me in this situation, similarly to @Jack17. it's always made sense to me that a lot of our issues were related to sensitization, and that my up and down swings directly relate to this. I very distinctly remember being the horniest in my life after stopping saw palmetto the first time, before getting to a PFS baseline of low libido and not great sexual health. I remember reading many stories of people essentially tapering off the right way after getting sides, and I feel healthy enough to try something. obviously this is dangerous and we have read reports of this going both ways, but I feel ready to do a little experimenting. I know I usually snap-back pretty well to very, very light AR-inhibs. Recently I remember reading about milk thistle having ARI properties, and feeling really good on that. Again, hair of the dog kind of situation. Feeling bold enough to try low dose saw-p finally.
Otherwise, it is good to note that all of my other symptoms, classic PFS mental/physical sides, have mostly subsided. I still don't have the drive in life I used to, but I think that might be partly mental. this whole experience chilled me out a good bit, and i'm so thankful I don't have the crippling anxiety and depression I had for a solid 1-2 years like at the beginning of this journey. Just need my sexual health back and I'll be good.
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I've noticed that after taking 500mg of niacin, I flushed super, super hard, and then proceeded to lose libido. this was about 3 weeks ago. It had been consistently good until that point, and I didn't feel necessarily bad after niacin, I just completely lost my libido. I've heard high doses of niacin can stop methylation, do you think this is what happened @Helen
Trump_1776
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