Role of glucocorticoid receptors

[Helen]

Yeah, we talked about quercetin with Ihatefin. look for the discussion, it was one of the things that helped me

 

[Slayo]

Yeah, we talked about quercetin with Ihatefin. look for the discussion, it was one of the things that helped me

Between curcumin and quercetin which one you would suggest ? I'm buying right now

 

[highserotonin90]

probably no one will answer anymore but can quercetin help in case of over-regulated GR receptors?

 

[ruprmurdoch]

over regulated ?

 

[highserotonin90]

over regulated ?

I am referring to the upregulation given by a chronically high level of acetylcholine due to a partially inhibited cholinesterase enzyme. Do you understand what I mean ? over time you have Addison's symptoms so I think GR is over regulated and it takes a huge amount of cortisol. ACTH now low. What do you think about it ?

 

[MNK99]

Ru486 and ellaone at different times helped me a lot. Ihatefin, Tubzy, and like lots of others also.
Not sure if quercetin is really helpful... The discord is more active. I can't login/ fix my login. I will try again sometime.

 

[highserotonin90]

Ru486 and ellaone at different times helped me a lot. Ihatefin, Tubzy, and like lots of others also.
Not sure if quercetin is really helpful... The discord is more active. I can't login/ fix my login. I will try again sometime.

I've been trying to reply to you privately for two days but it says "server error" or something similar while here the reply seems to work. I do not understand. Thanks for the advice regarding RU I thought it would be useful in cases of GR under regulation and not over regulation. Quercetin but also bee pollen makes me feel very ill but probably because it further increases acetylcholine.

 

[ruprmurdoch]

I am referring to the upregulation given by a chronically high level of acetylcholine due to a partially inhibited cholinesterase enzyme. Do you understand what I mean ? over time you have Addison's symptoms so I think GR is over regulated and it takes a huge amount of cortisol. ACTH now low. What do you think about it ?

if cortisol is high this means that GR is downregulated, beacuse you have low amount of GR
if cortisol is low this means that GR is upregulated, beacuse you have high amount of GR

in which point you are ?

 

[highserotonin90]

if cortisol is high this means that GR is downregulated, beacuse you have low amount of GR
if cortisol is low this means that GR is upregulated, beacuse you have high amount of GR

in which point you are ?

I think that in 3 months things have changed considerably regarding internal chemistry, now I have symptoms of both high and low cortisol, Cushing's and Addison's so I deduce that the gland is working with an abnormal signaling given the chronicity of too high acetylcholine . What do you think about it ? I also lost muscle mass, AR was probably affected by too much CO2 retention. Thank you!

 

[ruprmurdoch]

I think that in 3 months things have changed considerably regarding internal chemistry, now I have symptoms of both high and low cortisol, Cushing's and Addison's so I deduce that the gland is working with an abnormal signaling given the chronicity of too high acetylcholine . What do you think about it ? I also lost muscle mass, AR was probably affected by too much CO2 retention. Thank you!

really hard to without labs say something smart
but to jumpstart sytem you need vitamins b-b1,b2,b3,b5 that should increase your acth, cortisol levels. they create nadph, fad which create hormones.

 

[MNK99]

Pine pollen never worked for me, I am pretty sure I never tried Bee Pollen.

RU486 and ellaone possible? I used these awnd so did Ihatefin, Tubz, I think Goose, and many others as well. Like 5mg or 2.5mg of ru used ev day for a week or something. I can't remember what I did exactly there.

 

[MNK99]

Hmm. Yeah your issues are different but maybe something else can be done... Is fasting helpful for you? Have you tried?

Maybe there's something else.. TEI. I am not sure man what to do.

 

[zancek0]

It only helps with the symptoms of high acetylcholine, I think there is some type of pesticide that has irreversibly blocked the enzyme, not completely because I should already be dead. I tried fasting many years ago but it is not recommended for MS because they have faulty metabolisms especially lipids while we seem to tolerate carbohydrates well. Acidosis prevails which is why calcium helps me. Hydrogen great but I can't support it, I haven't tried other acidic things that push fat.

Sorry if you already wrote this anywhere but what's your "story"? What is your "syndrome"?

 

[ruprmurdoch]

Maybe until I unlock acetylcholinesterase it's useless for me to try to fix that receptor but I'll take note of these precious tips. I have MS so my focus is on myelin and having an efficient metabolism (I don't tolerate fats of any kind, very well with high calcium, carbs, salt, magnesium, potassium, protein...).

without labs hard to say
btw ru486 can cause big sides like minime had
i suggest labs hormones, electrolytes, aminos what can you afford
i suggest boreliosis igg, igm and toxoplasmosis igg, igm. later you can chceck diffrent parasites/ameobas

 

[ruprmurdoch]

i were on electrolyte protocol (mgcl+kcl+vit b in different dosages+ for some time whey proteins) from 10.2023, it help a lot but now-two weeks spiramycine toxoplasmosis treatment gives me the same amount of recovery like 7 months of electrolyte protocol.
beacuse tosxoplasmosis create alkalosis, (brain inflamation-encephalitis; head just grow), it create very bad ,,fork"(thats how helen call elevated prog and cortisol in the same time) thats why electrolyte protocol works.
so you see how important is testing. i would like that somebody said to me 15 yrs ago-,,mate test your igg and igm for toxoplasmosi'', it would save me a lot of everything.

in the end if you dont want to test, you can just try electrolyte protocol, but you see how important is finding a cause

i think big pharma and supplement industry know abt this. they made antitoxoplasmosis drugs very dear. it is not easy to get spiramycine in usa. one of manager said that antitoxoplasmosis drugs are ,ferrari". i agree with him. beacuse behind many disease is just toxoplasmosis. why ? thats why:
-prevalence in whole population-30%
-in some regions, like some parts of europe-50-80%
-toxo is eating folic acid- so no dna repair, no hairs, encephalitis(cfs, etc)
-toxo is sexoual route spreaded (check jaroslav flegr papers)
-many people with elevated igg have latent toxo-chronic disease

btw i prefer board than discord

 

[highserotonin90]

NAC hpa

N-acetylcysteine (NAC) supplementation can impact the hypothalamic-pituitary-adrenal (HPA) axis, which regulates the body's stress response[4][5]. Studies in mice have shown that NAC treatment induces hyperactivity of the HPA axis, leading to increased corticosterone levels[4][5]. This effect appears to be mediated by downregulation of peroxisome proliferator-activated receptor gamma (PPARγ) in the adrenal glands, which in turn upregulates adrenocorticotropic hormone (ACTH) receptors[4][5]. Activation of PPARγ with the agonist rosiglitazone was able to reverse the NAC-induced HPA axis hyperactivity and adrenal hypertrophy in mice[4][5]. These findings suggest that NAC's effects on the HPA axis may be related to its antioxidant properties and modulation of PPARγ signaling. However, further research is needed to fully elucidate the mechanisms by which NAC influences the HPA axis and stress response.

Citations:
[1] NAC | N-Acetilcisteina | Energia e difese immunitarie - HeBio Store NAC | N-Acetilcisteina | Energia e difese immunitarie
[2] Impact of N-acetylcysteine and sesame oil on lipid metabolism and ... Impact of N-acetylcysteine and sesame oil on lipid metabolism and hypothalamic-pituitary-adrenal axis homeostasis in middle-aged hypercholesterolemic mice - Scientific Reports
[3] NAC Aumentata | Integratore POTENZIATO negli Effetti ... https://www.amazon.it/Integratore-A...cetil-Cisteina-Biodisponibilità/dp/B0BV8M7SH5
[4] Activation of PPARγ reduces N-acetyl-cysteine - PubMed https://pubmed.ncbi.nlm.nih.gov/32574682/
[5] Activation of PPARγ reduces N-acetyl-cysteine -induced ... https://www.sciencedirect.com/science/article/abs/pii/S0891584920311059

 

[highserotonin90]

I was wondering in which cases NAC could help? in the case of over-regulation or under-regulation of GR?

 

[highserotonin90]

Scusa se l'hai già scritto da qualche parte ma qual è la tua "storia"? Qual è la tua "sindrome"?

Write me in PM

 

[ruprmurdoch]

> they made antitoxoplasmosis drugs very dear
A very polish mistake to make lmao

mistake ?