RU + Progesterone Cycle (PFS, PSSD)

[TubZy]

Great...I'm still feeling pretty good except libido and morning wood down just a bit today. I think it might be hard to manage all the changes but I think it could be prolactin like you said. I took some Inositol. I also have Selegiline ( they used it on Propecia help) to manage prolactin. Might be getting a little gynoco from estrogen. Not sure if I should take a little low dose of Clomid. I've tried DIM before but I think that did not work out.

My assumption is that over time progesterone will eventually lower testosterone if you stay on it for a long time, so that could be why your libido could be taking a small hit. Maybe pretty soon it could be wise to come off and see how you feel during snap back phase.

 

[bruschi11]

Great...I'm still feeling pretty good except libido and morning wood down just a bit today. I think it might be hard to manage all the changes but I think it could be prolactin like you said. I took some Inositol. I also have Selegiline ( they used it on Propecia help) to manage prolactin. Might be getting a little gynoco from estrogen. Not sure if I should take a little low dose of Clomid. I've tried DIM before but I think that did not work out.

Don’t touch clomid. Will mess with this too much.

 

[bruschi11]

What do you think causes premature ejaculation? And what helps eliminate it? I go through periods of it

Guessing prolactin here. I don’t know- RU causes such a hormonal change in so many hormones. It could be anything.

 

[brix]

Guessing prolactin here. I don’t know- RU causes such a hormonal change in so many hormones. It could be anything.

Interesting. I would imagine low prolactin would cause premature more so than elevated prolactin. Right now my **** is so sensitive that I’m ready to finish within moments of penetration. Even after low dose lisuride which suppresses prolactin and serotonin.

 

[bruschi11]

@TubZy could we rename this thread "RU/PROG together" or something in that matter? Might be smart and we can see a collection of guys who try it here.

Anyways, I crashed badly yesterday morning (day 1 post RU, day 4 prog 10mg-12mg) with major fatigue, near impotence. So I decided to stay away from prog today and doing better. Libido actually coming back right now. Still taking L-dopa (2 pills morning, night I believe 600mg each pill) and inositol (10g morning).

Will likely go back to prog tomorrow at lower dose like 5mg. Maybe take 2 full days off we'll see.

 

[bruschi11]

Gotta realize the half life of both RU and prog. RU very long. Prog also has a longer half life so its still definitely piled up in my system. Need to look up their half lives.

 

[Jack17]

@TubZy could we rename this thread "RU/PROG together" or something in that matter? Might be smart and we can see a collection of guys who try it here.

Anyways, I crashed badly yesterday morning (day 1 post RU, day 4 prog 10mg-12mg) with major fatigue, near impotence. So I decided to stay away from prog today and doing better. Libido actually coming back right now. Still taking L-dopa (2 pills morning, night I believe 600mg each pill) and inositol (10g morning).

Will likely go back to prog tomorrow at lower dose like 5mg. Maybe take 2 full days off we'll see.

My assumption is that over time progesterone will eventually lower testosterone if you stay on it for a long time, so that could be why your libido could be taking a small hit. Maybe pretty soon it could be wise to come off and see how you feel during snap back phase.

Wow... Good to keep track of these set backs. Why do you think this happened?? I'm planning to come off progesterone soon. I think the benefit peaked two days ago. Have NOT had a huge drop off. I think I got to maybe 85% normal and dropped to maybe 65%. I'm still better off right now than before starting Prog.
It's really hard to quantify but I think it helps to track.


I Agree with name change. Thanks. Would be great to have more guys trying this as I think it is a promising protocol.

 

[bruschi11]

@Jack17 RU blocks cortisol, progesterone blocks cortisol. Combination just obliterated a CFS/PFS ridden body like mine. I need cortisol for my specific subtype very badly.

 

[Jack17]

@Jack17 RU blocks cortisol, progesterone blocks cortisol. Combination just obliterated a CFS/PFS ridden body like mine. I need cortisol for my specific subtype very badly.

Hard to know but do you think it was too much RU or Progesterone or the combo. Maybe the set back is the way to improve for the snap back??? I'm stopping progesterone today. I'm going to stop Progesterone tomorrow so that would be ten days. I will not be taking RU during four day off period. I started taking more Inositol as I think has been going up, but not sure.

 

[MNK99]

Re: Half-lifes:
1. Topical Progesterone:
Acc. To WIkipedia:

"A study that investigated the pharmacokinetics of topical progesterone using a hydrophilic (gel), lipophilic, or emulsion-type base found that in all three cases the time to peak concentrations was around 4 hours and the elimination half-life was in the range of 30 to 40 hours."

Acc. To https://scholar.google.ca/scholar?hl=en&as_sdt=0,5&q="half+life"+of+"topical+progesterone"&btnG=
I think (oral) progesterone a high clearance rate 2-5mins. It also has poor bioavailability so like others said the topical's the way to go.

2. ru486:
Basic Mechanisms Controlling Term and Preterm Birth
isbn:3662216604 - Google Search
Kristof Chwalisz, ‎Robert E. Garfield - 2013 - ‎Medical

the half-life of RU486 ranges between 24–48 h (Heikinheimo, 1989)
Endogenous glucocorticoids modulate neutrophil function in a murine ...
Endogenous glucocorticoids modulate neutrophil function in a murine model of haemolytic uraemic syndrome

by SA Gómez - ‎2005 - ‎Cited by 19 - ‎Related articles

Sep 30, 2004 - The metabolic half life of Ru486 is of about 20–24 h [13], and repeated intraperitoneal administration of Ru486 daily in mice has been shown to completely deplete mice from endogenous GC effects [14]. Moreover, Ru486 is used to determine the specificity of GC-receptor mediated functions in diverse ...

-I've seen 25-28hrs elsewhere.

 

[bruschi11]

Mucuna Pruriens (l-dopa) was more potent for me than inositol for prolactin sides. Far more to be honest. I’m using both but I’m fairly positive that mucuna was what actually helped. I literally feel the dopamine from mucuna.

I think the combo of RU/prog was too much run concurrently for the days of RU and day or so afterward. I think it’s important we get RU in our system with a low amount of prog following afterward. 5mg of prog today feels better than the 10mg. I think I’m going to go even less tomorrow with 3mg.

 

[Jack17]

Re: Half-lifes:
1. Topical Progesterone:
Acc. To WIkipedia:

"A study that investigated the pharmacokinetics of topical progesterone using a hydrophilic (gel), lipophilic, or emulsion-type base found that in all three cases the time to peak concentrations was around 4 hours and the elimination half-life was in the range of 30 to 40 hours."

Acc. To https://scholar.google.ca/scholar?hl=en&as_sdt=0,5&q="half+life"+of+"topical+progesterone"&btnG=
I think (oral) progesterone a high clearance rate 2-5mins. It also has poor bioavailability so like others said the topical's the way to go.

2. ru486:
Basic Mechanisms Controlling Term and Preterm Birth
isbn:3662216604 - Google Search
Kristof Chwalisz, ‎Robert E. Garfield - 2013 - ‎Medical

the half-life of RU486 ranges between 24–48 h (Heikinheimo, 1989)
Endogenous glucocorticoids modulate neutrophil function in a murine ...
Endogenous glucocorticoids modulate neutrophil function in a murine model of haemolytic uraemic syndrome

by SA Gómez - ‎2005 - ‎Cited by 19 - ‎Related articles

Sep 30, 2004 - The metabolic half life of Ru486 is of about 20–24 h [13], and repeated intraperitoneal administration of Ru486 daily in mice has been shown to completely deplete mice from endogenous GC effects [14]. Moreover, Ru486 is used to determine the specificity of GC-receptor mediated functions in diverse ...

-I've seen 25-28hrs elsewhere.

Thanks! Half life not as long as I thought.

 

[Jack17]

I stopped progesterone Friday. I was feeling like the benefit was fading but still higher than baseline. Seemed to dip more on Saturday and Sunday. It's really hard to say for sure but I feel a little better today. Strong morning wood and libido higher than previous two day. Maybe it's the snap back. I am thinking I will stay off Progesterone for one week and then restart. I have noticed a lot more hair loss over past two weeks. It's probably related to more DHT as I also have the DHT scalp itch. So it seems like this protocol has boosted mood, libido, MW and objectively noticed hairloss all from more DHT.

 

[Jack17]

Mucuna Pruriens (l-dopa) was more potent for me than inositol for prolactin sides. Far more to be honest. I’m using both but I’m fairly positive that mucuna was what actually helped. I literally feel the dopamine from mucuna.

I think the combo of RU/prog was too much run concurrently for the days of RU and day or so afterward. I think it’s important we get RU in our system with a low amount of prog following afterward. 5mg of prog today feels better than the 10mg. I think I’m going to go even less tomorrow with 3mg.

How are you doing??? Are you still on progesterone?

 

[bruschi11]

@Jack17

I still have a few more days on it. Definitely libido increased. Probably hurt erections a little (combined with RU increasing prolactin and I didn't want to touch the metergolines, cabergolines of the world).

Prog will create hair loss per @gbolduev as you notated above. My hair is pretty great these days , but I think its shedding a little bit more.

I think prog/RU depending on the person, their subtype, and what they do along with it is something that could be done every few months and if the person is very healthy, they can get out of PFS from it. I'm just not- I'm not very healthy as I still have lingering CFS issues I need to deal with before going back to the drugs.

I'm going to stop prog Thursday but might dose it 5mg or so once a week coming up. We will see.

 

[Jack17]

@Jack17

I still have a few more days on it. Definitely libido increased. Probably hurt erections a little (combined with RU increasing prolactin and I didn't want to touch the metergolines, cabergolines of the world).

Prog will create hair loss per @gbolduev as you notated above. My hair is pretty great these days , but I think its shedding a little bit more.

I think prog/RU depending on the person, their subtype, and what they do along with it is something that could be done every few months and if the person is very healthy, they can get out of PFS from it. I'm just not- I'm not very healthy as I still have lingering CFS issues I need to deal with before going back to the drugs.

I'm going to stop prog Thursday but might dose it 5mg or so once a week coming up. We will see.

Remind me, what does CFS stand for? So you are not going to repeat the course?

 

[MNK99]

Chronic Fatigue Syndrome.

 

[bruschi11]

Remind me, what does CFS stand for? So you are not going to repeat the course?

No it was never really part of my plan to repeat the course. I did it for a quick boost before I really got into balancing. I know it definitely can increase baseline as it did in December for me. And I expect this to increase baseline even more.

I will likely do another short run late Summer or in fall. I plan on next 10 weeks working on balancing, diet, working out, aminos, betaine HCL. Then fasting most of June.

 

[Jack17]

Some data on low dose naltraxone and chronic fatigue. Have you tried it?

 

[bruschi11]

Some data on low dose naltraxone and chronic fatigue. Have you tried it?

I have a whole system right now for me that is going well, but eventually LDN is something I may use. My CFS was caused by a combination of pathogens (severe mycoplasma infection), toxins (highly elevated ammonia which was likely from the mycoplasma), heavy metals, mercury, slow oxidation it appears.

###

Woke up with strongest morning wood of PFS. No doubt. This was after having pretty much zero or bad morning/nocturnals during this whole RU/prog cycle thus far. Its weird cuz I was feeling more libido, but not getting erections.

This is on day 9 prog, day 6 post RU. I'm thinking I might run 11 days of prog here overall and take 4 days off then follow it with 8 or so days of prog. Then I'm going on vacation for 4 days so I don't want fatigue during it.

If I get such good sexual effects from cycling prog. I can't stop using it. I want my cock back 100% lol a little fatigue can't get in the way. Also, I'm drinking coffee for first time since August really to help with the fatigue and its helping a lot. I think I'm just going to do this when using prog so I don't develop a severe caffeine addiction like I had for about 10 years there haha.

I'm now using one mucuna pruriens (L-dopa) pill in the morning to help curb prolactin. I think using more than that was too much and was causing fatigue itself.

Good things this 24 hours. I was feeling really normal last night it was so cool.