RU + Progesterone Cycle (PFS, PSSD)

Jack17

Well-Known Member
Messages
321
Thanks!
This is such a complicated illness/ disorder....I continue to believe this protocol offers a (possible) path to recovery but there are pitfalls that need to be identified and addressed along the way. I feel compelled to use RU or Ella but it's unclear if that's the right thing to do. The first three times I felt a boast from it and good results from the subsequent progesterone cycle. In fact the second time I used RU 25mg for 3 days, I felt 110% of normal. I felt completely normal to better than normal. This dropped on fourth day, I believe from the rising Prolactin. This last time only took <10mg (est) of RU and then progesterone. I felt no benefit with this cycle. I think taking too much progesterone or taking too long or not giving a long enough break between cycles will likely have a neg effect. We are seeking something to reset the normal process; to fix what ever has been damaged or reset in a negative and persistent state. We know that progesterone typically will decrease libido in normal men. For us, it can help but you have to consider that at the same time there can be a potential for worsening of symptoms. There could be a regimen that will help stimulate the resetting process but over or under doing it will cause no benefit. So for now I believe that you have to keep the dose 5mg or less. Make sure you take enough time off between cycles to bounce back and control prolactin. Still not sure where RU/ Ella fits in. Except for a couple minor few day set backs, I have benefitted from this protocol for the past 2.5 months.
 

Jaxx

Well-Known Member
Messages
683
Thanks!
This is such a complicated illness/ disorder....I continue to believe this protocol offers a (possible) path to recovery but there are pitfalls that need to be identified and addressed along the way. I feel compelled to use RU or Ella but it's unclear if that's the right thing to do. The first three times I felt a boast from it and good results from the subsequent progesterone cycle. In fact the second time I used RU 25mg for 3 days, I felt 110% of normal. I felt completely normal to better than normal. This dropped on fourth day, I believe from the rising Prolactin. This last time only took <10mg (est) of RU and then progesterone. I felt no benefit with this cycle. I think taking too much progesterone or taking too long or not giving a long enough break between cycles will likely have a neg effect. We are seeking something to reset the normal process; to fix what ever has been damaged or reset in a negative and persistent state. We know that progesterone typically will decrease libido in normal men. For us, it can help but you have to consider that at the same time there can be a potential for worsening of symptoms. There could be a regimen that will help stimulate the resetting process but over or under doing it will cause no benefit. So for now I believe that you have to keep the dose 5mg or less. Make sure you take enough time off between cycles to bounce back and control prolactin. Still not sure where RU/ Ella fits in. Except for a couple minor few day set backs, I have benefitted from this protocol for the past 2.5 months.

Do you have the feeling it helps you with getting your emotions back as well?
For me it helps mainly for the sexual part, but i am only in week 2 so could be too early to tell ofc. I dont feel entirely normal yet, but my dick feels part of my body again.
 

noprop

Well-Known Member
Messages
499
I am doing intermittend fasting, too.
I have already posted the benefits.
Keep trying - let us know what you experienced. Great job! Best
 

Jack17

Well-Known Member
Messages
321
Update: I've been off progesterone for 6 days. I have felt a mild improvement over the past two days regarding libido. Mentally I'm good maybe at 90%. Libido and ED are down at about 40-60% over past week. I decided today to do a short Ella run at 5mg a day for three days. I will plan to restart Progesterone a day or two after finishing it. The reason I'm doing this is because I think the RU/ Ella may help with the progesterone effect ( I could be way off base here). I've used RU for the past couple of times and each time had a good post progesterone course. The last time only used a very small dose of RU but the following progesterone course was not beneficial. On the positive side, looking back on my notes, I have had good results for 9-10 weeks and I believe that's long enough to (hopefully) believe the benefit from this is not fading. In fact May 2nd I was feeling great.
 

Jack17

Well-Known Member
Messages
321
Do you have the feeling it helps you with getting your emotions back as well?
For me it helps mainly for the sexual part, but i am only in week 2 so could be too early to tell ofc. I dont feel entirely normal yet, but my dick feels part of my body again.
Yes, emotionally a lot better.
 

Sam90

Member
Messages
33
Yes, emotionally a lot better.

Jack how are you measuring out your RU? I have just ordered one pill but I don't think the scales I have will be sensitive enough to measure small doses.

Also - which progesterone cream are you using?

Thanks
 

Jack17

Well-Known Member
Messages
321
Jack how are you measuring out your RU? I have just ordered one pill but I don't think the scales I have will be sensitive enough to measure small doses.

Also - which progesterone cream are you using?

Thanks
Measuring RU is difficult. I don't use a scale I half the pill then half again and estimate. I am currently using the Biovea brand but am almost out. I am currently taking Ella for three days. I think it's important to let the RU get out of your system before starting Progesterone. This is my opinion but I would think you would not want both competing for the same receptor site. But there may be a benefit from using the benefits of an agonist/ antagonist drug to help reset the progesterone receptor. This may increase the sensitivity of the receptor and then use progesterone. I'm not sure if this is true but it seems reasonable. With Ella it's 6 days off then progesterone. It's probably 4 days with RU.
 

Jaxx

Well-Known Member
Messages
683
@Jack17
I notice that the effects fade out a bit in my 2nd week of the cycle. Do you experience the same? On the propecia thread they say that there are bound to be ups and downs during the cycle.
Alternative idea is that the dose is too high and the body reacts to it?
 

Jack17

Well-Known Member
Messages
321
Hi Jaxx,
You totally have to accept the ups and downs of progesterone but with that said, how much progesterone are you using ( goal dose around 2.5mg) have to stay off progesterone for at least 4 days between cycle maybe 7 days would be better. Have you tried RU/ella? Very important to control prolactin. What are you doing for that?
 

Jack17

Well-Known Member
Messages
321
Update:
I did two days of Ella 5mg last Thursday and Friday. I got a big headache Friday even with taking Caber 1/2 tab on Thursday and Friday. I think this shows that the rise in Prolactin is significant and may require more aggressive treatment than some are doing. Low libido Thursday, Friday slight elevation and Sunday night starting feeling increase. This morning had very strong morning wood and much higher libido. This is probably the bounce back from Ella, but still it's good. I think I will continue to stay off progesterone for at least 6 days to make sure Ella is out of my system. I've read an interesting idea from Joekool about estrogen and sensitizing the androgen receptor. I wonder if a very short round of pregnalone or topical DHEA to give add a little estrogen would help or hurt. This will confuse the progesterone protocol progress but it's important to consider these things.
The answer is out there we just have to find it/ figure it out!
 

bruschi11

Administrator
Staff member
Messages
2,705
If I were you, I'd do one or two more short spurts with prog and then jump off everything and see where it leaves you, Enjoy a few weeks of summer clean and see if this stuff is lasting for you. Maybe your body will shift into a cured state. Maybe it will shift backwards.

Whats longest you've gone clean now @Jack17 and what occurred during that time period?
 

Jack17

Well-Known Member
Messages
321
Good idea! I wasn't really taking anything last Oct, Nov, Dec time frame. I did the high dose clomid in August and did really well, essentially normal until the end of September then it slowly faded away. I started looking at this board in January because of the relapse or failure to hold the normal. I was intrigued with the RU/ Ella idea. I started January with a course of higher dose Zinc and felt horrible for a couple days and then normal for a couple of days. I started the electrolyte regimen after the zinc trial so I was confused about the results. At first I thought the electrolyte protocol was working but then I realized it was probably just rebounding from stopping the zinc.

Something causes this to persist. There is something that doesn't allow the 'normal" to stick. We need to identify it. Maybe it's the prolactin. Maybe some ratio between progesterone, estrogen, testosterone. Maybe what ever is helping with the receptor recovery stops. It's very frustrating.
 

Jaxx

Well-Known Member
Messages
683
Hi Jaxx,
You totally have to accept the ups and downs of progesterone but with that said, how much progesterone are you using ( goal dose around 2.5mg) have to stay off progesterone for at least 4 days between cycle maybe 7 days would be better. Have you tried RU/ella? Very important to control prolactin. What are you doing for that?
Macunu pruriens for prolactin (as i dont have selegiline) and a small piece of cream, see picture. The propeciahelp forum thread was the reference.
I have tried ella, which helped a bit for 2 days, but declined back fast. Interestingly i also tried levonorgestrel, which castrated me within a couple of hours. Shrinkage as well, but zero brain fog. Took about 2 weeks to reach back to normal.

IMG_1909.JPG
 

Jack17

Well-Known Member
Messages
321
That amount looks right. Macunu pruriens might not control Prolactin rise enough. Can you get Caber? This could be the reason for the diminished results. Interesting observations with levonorgestrel. From your symptoms, It probably dropped your Testosteron to zero! I'm not familiar with anyone having that happen with Ella/RU. It would be interesting to determine why Levonorgestrel effect is different than Ella/ RU.
 

Jaxx

Well-Known Member
Messages
683
That amount looks right. Macunu pruriens might not control Prolactin rise enough. Can you get Caber? This could be the reason for the diminished results. Interesting observations with levonorgestrel. From your symptoms, It probably dropped your Testosteron to zero! I'm not familiar with anyone having that happen with Ella/RU. It would be interesting to determine why Levonorgestrel effect is different than Ella/ RU.
My idea was it dropped my prog to zero actually (or closer to, we might just be insensitive to it, why it is high in the first place). Levonorgestrel is not a modulator
 

Jack17

Well-Known Member
Messages
321
My idea was it dropped my prog to zero actually (or closer to, we might just be insensitive to it, why it is high in the first place). Levonorgestrel is not a modulator
Right., it's not a modulator so must be important that Ru/ Ella are agonist/ antagonist. It also stimulates androgen receptor. Wonder if that is the reason for the bad out come. Anyway, think about the prolactin issue. I think it's important for me.
 

Jaxx

Well-Known Member
Messages
683
Right., it's not a modulator so must be important that Ru/ Ella are agonist/ antagonist. It also stimulates androgen receptor. Wonder if that is the reason for the bad out come. Anyway, think about the prolactin issue. I think it's important for me.
Yeah i am trying to get selegiline legally, lets see if that works out. If not i might change tactics. It is interesting, moclobemide also worked for a good week, wonder now if that effect was also prolactin. Moclobemide effects on prolactin plasma levels in healthy individuals: the hormonal increase induced by a single dose is maintained during a 4-week... - PubMed - NCBI

However, moclobemide is not associated with sexual dysfunction.
 

Jack17

Well-Known Member
Messages
321
A lot of guys thought Selegiline was important on propecia help. It's implicated in some neuro protective properties and some believe it may reverse some of the nerve damage from PFS. I actually think the benefit is mainly mitigating the rise in prolactin. If you read the propeciahelp board some of the people that had no benefit or transient benefit were not taking anything like selegiline to control prolactin. Another guy was taking progesterone and Clomid together and wasn't benefiting.
 

RuProgStack82

Member
Messages
31
I wonder if the licorice cycle has the same effect as the ru cycle. Jack did you do a licorice cycle? If so how would you compare it to the ru prog cycle?


If Prolactin is an issue so why not take very small amounts of ru like 1-2 mg for 2 weeks.
 
Last edited: