Ulcerative Colitis / IBD

[Helen]

It looks very promising. Especially for UC reg. C.difficile and E.Coli
If you say it works well, did you use it or heard of it?

I used it many times. It is a very good binder. Also very gentle , does not cause gas or anything. I thought it would fit your case the best

I used that and algin for my chelation sessions. Pecta Clear was also good but expensive. It has modified pectin plus algin.

 

[HerrFisch]

Would you recommend malic acid for UC as well, or is it too hard on the gut?

But anyways, Enterosgel is probalby a better choice. I might try it. Thanks

 

[Helen]

@HerrFisch

I think your goal is to lower free copper. That you can do thru the work of MTs. Mts need glutathione to work. So you need to support all those .

You need to be taking aminos plus HCL at all times. PLus zinc , boron, molybdenum , selenium , b6, etc. Iron is optional , I know you are really low in it now. since you bleed all the time. But if you take HCL you will absorb it ok.

PLus as a binder , use entergosgel. Also you can drink Nopal juice to get into remission with the gut problem. It does not fix UC , but at least can help sooth it to digest stuff better.

UC is a free copper problem. We have seen it on hairtests of most UC people. You need to support glutathione , plus metalothionine. If you did amino acids profile, you would see where your problem is. But you can support cysteine, glycine ,glutamic acid, folic acid. I bet if you follow the protocol for improved health, you will get cured.

this is why just minerals hardly help it and even can cause more problems. YOu need to concentrate on amino acids. Same as with Wuf, minerals, multivitamins made him worse always.

UC is a lack of amino acids. It is not some bacteria in your stomach. Since UC people get ulcers in the mouth just as often. There is also anemia and hemolysis , and free copper inhibiting G6PH.( this causes ROS) Not to have free copper inhibiting G6PH you need to keep your metabolism high. as you already know.

Most UC people as I did some research now, get UC AFTER they get mouth ULCERS first. So the gut being less exposed to oxygen goes second.


So what I would do in your case is this:

1) HCL with amino acids ( HCL after every food) plus electrolytes, could add gelatin to it also
2) Zinc , boron , b6, molybdenum, reduced GSH. folic acid selenium vit C( play with this, since if you add aminos with HCL , you might not even need all these))
I dont like synthetic minerals at all, that is why I recommend that you take in nutriplex whole food multivitamins, This is the only company I know which makes them from food so bound to an amino acid . All others just feed yeast with synthethic minerals

3) Nopal juice
4) Enterosgel to help bind stuff.

 

[wuf]

@HerrFisch In russia people use enterosgel as a binder. It works well . You might look into it.

I am back from Kiev. I bought 1 kg of that stuf...spent like 6 euros, so cheap!!
So, do you reccomend it? It was a question I had loaded in my gun, but still didn't shoot out.
If you think it is safe to run even for PFS, I can try it... I mean I am speaking about copper etc, since I am PFS and crashed from DHEA and have UC, (good state at the moment).
@gbolduev I will ask everytime before to use any supplements.
I can confirm that since I am focused on aminos etc as "health..." protocol suggest, my UC is fine.
Thank you.

 

[HerrFisch]

Focusing on amino acids was my plan,

only thing Im worried about is your suggestion to take b6.
Of course my thoughts are only bad bc of histamine and b6 connection. But actually, if HDC is 10 fold increased from ROS I tdont think that b6 will make this much of a difference.

Will this + exercise be enough to keep metabolism high or do think of anything else to add to keep it high?

 

[HerrFisch]

That is why when you dont utilize Co2 correctly , your cortisol will be up and it will retain sodium and in this case SODIUM is your saver. Since it will increase ventilation and adrenaline sensitivity in the cell.

I feel like an increase in my sodium levels helping me with IBS.
I noticed it instantely with licorice. Its probably due to adrenaline conversion or sensitivity ?

But I guess I should stop it because of cortisol burning extra potassium right? Or would potassium + adding small amount licorice be ok?

Btw right now Im still using potassium citrate + magnesium chloride hexahydrate. Should I switch to potassium chloride as well?

 

[HerrFisch]

Ok I need to ask again.., does anybody know or could guess what the connection is with caffeine, sport, nicotine and now licorice helping me?

I tried licorice days on and off and feel so much better with it. Its even better than caffeine or nicotine.

Could it be the imroved adrenal, metabolism or adrenaline sensitivity? My hair test sodium levels are not that low though.
Or just better cortisol levels?

Are there better ways to maybe get those effects I get from licorice?

I had to use cortisone in the past for UC btw, so having enough potassium and lowering free copper to maybe get some iron is my way to go right now. (cortisol sensitivity)
But I know it is said licorice will lower potassium, would it hurt adding licorice to potassium and magnesium cloride, hcl, aminos etc ?

And Im kind of unsure about iron levels in UC. Could be low from bleeding but could be high and biounavailable kind of because of pathogens?

[Im at 2g elemental potassium,~250mg elemental magnesium, 6g Betaine Hcl, 50g of hydrolized whey, active b2 1.5mg, reduced glutathione 150mg, egcg 350mg. And some lysine,glycine taurine, glutamine.]

 

[mattyb]

Doesn't licorice just increase cortisol availability?

All of those (sport, caffeine, nicotine, licorice) either increase cortisol availability or cortisol usage. Sport and nicotine have the advantage of doing this, but also diverting blood flow away from the colon, decreasing local metabolism and ROS formation there.

 

[Helen]

licorice increases cortisol, this increases sodium. When sodium is increased this lowers conversion of dopamine to adrenaline. Since adrenaline is needed less. Sodium is adrenaline receptor in the cell. Same as potassium is thyroid receptor.

 

[HerrFisch]

Probably yes, looks like metabolism local at the gut does not fit to overall metabolism.

Upregulated metabolism at center of inflammation etc but not enough adrenal thyroid etc for cortisol ... ?

So you would need to decide weather you go all low or all high.
Fasting "long term" would lower metabolism everywhere providing time to heal.
Different approach increasing metabolism with help of potassium, helping fight ROS + chelation?

I think histamine problems would be helped with fasting due to less histidine or protein in general, and if you increase metabolism, your histamine will go down because of more cortisol.

And slow metabolism with lots of protein is probably worst?

 

[HerrFisch]

licorice increases cortisol, this increases sodium. When sodium is increased this lowers conversion of dopamine to adrenaline. Since adrenaline is needed less. Sodium is adrenaline receptor in the cell. Same as potassium is thyroid receptor.

So do you think it will do harm? Even when I just stack it to electrolytes + aminos ?

 

[Helen]

I think you will need to improve metabolism thur methylation , instead of sodium. when you see that your sodium is going up in hair. that would mean that the adrenaline production is going up. ( methylation) and the body will be willing to lose sodium from the cell. this will happen when your thyroid goes up , and this will start up adrenaline side. I think you need to follow what raincoast did
he just chelated copper and used aminos and electrolyte and tons of HCL. This increased methylation and thyroid.

I think licorice is a stilt here.

 

[HerrFisch]

I think you will need to improve metabolism thur methylation , instead of sodium. when you see that your sodium is going up in hair. that would mean that the adrenaline production is going up. ( methylation) and the body will be willing to lose sodium from the cell. this will happen when your thyroid goes up , and this will start up adrenaline side. I think you need to follow what raincoast did
he just chelated copper and used aminos and electrolyte and tons of HCL. This increased methylation and thyroid.

I think licorice is a stilt here.

Would you go as far and say UC started basically as potassium deficiency? (if one could say it that "easy")
Because things like free copper etc would happen after that. Something like high cortisol demand but potassium missing after some time? And metabolism slows down = less adrenal function. Not enough cortisol -> inflammation, histamine high, copper increases, iron gets biounavailable ->free radicals (or copper / iron) gets traced as "pathogen". Maybe copper takes over because of its antibacterial abilities for "pathogens" .

Electrolyte and acid-base disorders in inflammatory bowel disease

But yes, Im trying to do what Raincoast did

 

[HerrFisch]

@mattyb maybe you can help me,

My doc always tests for calprotectin as a marker for inflammation. Now my last calprotectin was really low, and this did tell him its not colitis.
And because of that, and that my colitis and ibs is not as he wishes, he probably wants me to change from azathioprine to something like TNF alpha blockers.

I had this possibility already in mind and felt that this flare is not "normal".
I thought that this flare is not due to extremly high ROS but maybe just lower SOD or because of copper chelation or histidine / high histamine. So even normal levels of ROS can do harm.
But I think chelation of copper is still the way to go and as soon as I got perfect copper levels, I will be better. I think this is just a time with 0 bioavailable copper from chelation, so even worse than extreme high copper but better after chelation, if copper bioavailability gets better.

I think Copper toxicity is used as a mechanism to control infections / pathogens -> CU

So I looked up calprotectin and it looks like it is a protein which chelates zinc +manganese. And it is supposed to be antibacterial, fungi etc.
Is calprotectin working by increasing free copper?
And how does calprotectin levels change with lowering free copper, supplementing zinc and manganese?

I find it really interesting that calprotectin chelates both zinc and manganese, and probably induces my copper toxicity. But I wonder if its possible to draw conclusions from that on iron.
In general I would say if manganese levels decline, Iron would increase or get biounavailable. Another possible ROS source ? @gbolduev
[I read that low levels of manganese can only be increased by up to 300mg of manganese? Im wondering if I should try this 75mg manganese suggestion from ARL?]

 

[mattyb]

The role of calprotectin in withholding zinc and copper from Candida albicans. - PubMed - NCBI
The Effects of Calprotectin, A Metal Binding Protein, on the Growth of Borrelia burgdorferi

Calprotectin binds copper as well, but not as much. It has two binding sites, one for zinc, and one for copper/manganese/zinc. So it will imbalance zinc/copper, sequestering more zinc than copper.

I think histamine downregulates calprotectin.

I think you should stop screwing around with supplements and just fast. That will chelate copper faster than anything. Messing with supps has just made you worse.

Infliximab or something like that is okay, I guess. But the hard thing in starting along that treatment path is that getting off the drug is super hard - almost no one ever comes off it (I did find one girl with Crohn's, who got off it through repeated modified three week fasts). But if it's the only thing that will work, then absolutely go for it because the side effects are better than suffering severe GI problems.

 

[HerrFisch]

@mattyb Just curious, where did you find this connection between histamine and calprotectin? Cand find anything about it downregulating CP

I am going to stay on electrolytes hcl and aminos for some time now, I think I am noticing improvements and I have hopes in it.
Just wanted to point out with that post that there is one more connection between copper toxicity and UC.

About Infliximab, actually Im kind of scared of its side effects, and I did not actually have that much problems with flare ups / UC.
I just wanted to get rid of my IBS in the past, which took me into flare pretty often. But I got out as quick. I just took the wrong ways, like p5p or caffeine or palm oil.
I see now, that there was something missing. Increasing my metabolism did help, but I guess just Increasing metabolism without helping the body does make no sense.

I mean metabolism is down for a reason, so just increasing it witouth feeding things or helping to bind things probably made me worse.

 

[HerrFisch]

Little update,,

had some improvements being on the electrolytes + amino + hcl. 4-5g Potassium chloride and 1g magnesium chloride, 1g sodium chloride. Actually added some folic acid 400mcg, selenium 200, boron 3mg, zinc 25, manganese 25.

It feels like my metabolism "baseline" picked up and is a bit higher now. I feel more awake and "ready". I think my methylation went up a bit.
And it looks like that things which would give me a fast increase in metabolism like caffeine smoking or stress does not bother me that much anymore!
Thats good. Really good.

Normally smoking would pull me out of a hole, I would get dizzy and then my metabolism would go up and my IBS would be good.
Now smoking etc does not do anything and I feel like metabolism is already up. So there are less adrenaline "surges".


UC inflammation wise, there are slight improvements, but it seems like over night, it gets worse again.
I wake up, still having my histamine / diarrhea problems. After lunch digestion problems changes from diarrhea to perfect stools. No blood . Evening everything is at its best.
But over night, its starting to bubbeling in my colon and the next morning Im back to weird histamine/diarrhea and blood. Its weird that it changes so fast.

And everybody with UC will agree with me, that full day diarrhea is not as bad as the time span in which diarrhea changes back to normal. Mixed is bad and hurts LOLL

Im still using 1-2mg predisone enema in the evening. I wonder if that could make some problems over night, but am I not using it for that matter actually?...
It seems like there is still some small problem with cortisol. I wonder if I should try adding some iron. I think upping manganese seemed helping a bit as well.

I was drinking some alcohol free beer lately and it seems it was helping a bit for UC.
I read something similar to that, someone "cureing" his Crohns with beer Lol.
But on the other hand, when I was drinking friday and saturdays regularely, not careing about "health", I had 0 problems with UC.

Im seeing good improvements, maybe it just takes some more time.
And by the way, I need to pee a lot lately.

 

[Legna88]

@HerrFisch

I think your goal is to lower free copper. That you can do thru the work of MTs. Mts need glutathione to work. So you need to support all those .

You need to be taking aminos plus HCL at all times. PLus zinc , boron, molybdenum , selenium , b6, etc. Iron is optional , I know you are really low in it now. since you bleed all the time. But if you take HCL you will absorb it ok.

PLus as a binder , use entergosgel. Also you can drink Nopal juice to get into remission with the gut problem. It does not fix UC , but at least can help sooth it to digest stuff better.

UC is a free copper problem. We have seen it on hairtests of most UC people. You need to support glutathione , plus metalothionine. If you did amino acids profile, you would see where your problem is. But you can support cysteine, glycine ,glutamic acid, folic acid. I bet if you follow the protocol for improved health, you will get cured.

this is why just minerals hardly help it and even can cause more problems. YOu need to concentrate on amino acids. Same as with Wuf, minerals, multivitamins made him worse always.

UC is a lack of amino acids. It is not some bacteria in your stomach. Since UC people get ulcers in the mouth just as often. There is also anemia and hemolysis , and free copper inhibiting G6PH.( this causes ROS) Not to have free copper inhibiting G6PH you need to keep your metabolism high. as you already know.

Most UC people as I did some research now, get UC AFTER they get mouth ULCERS first. So the gut being less exposed to oxygen goes second.


So what I would do in your case is this:

1) HCL with amino acids ( HCL after every food) plus electrolytes, could add gelatin to it also
2) Zinc , boron , b6, molybdenum, reduced GSH. folic acid selenium vit C( play with this, since if you add aminos with HCL , you might not even need all these))
I dont like synthetic minerals at all, that is why I recommend that you take in nutriplex whole food multivitamins, This is the only company I know which makes them from food so bound to an amino acid . All others just feed yeast with synthethic minerals

3) Nopal juice
4) Enterosgel to help bind stuff.

@gboldue, when you say 'aminos with HCL', you mean aminos in a supplement form(powder/pills) or amino from food protein sources+HCL (because HCL will aid in the brakedown of protein into aminos)?

and it should be a full spectrum free form amino blend(both essential and non-essential ones) or only an essential free form bend?

how many grams/day of aminos(essential or full spectrum) should a non-athlete and an athlete take?

 

[HerrFisch]

Its getting better and better

Stopped with prednisone and added some more salt. Histamine and blood issues are almost gone? My doc wont believe me lol.

I stopped my magnesiumCl for some days because I thought I felt better without it. And added more salt. Felt immediately better! And even with magnesiumCl.
Im pretty sure I was low on sodium. My mom is really scared about using too much sodium. So we use table salt that is only 1/5 sodium. And we even use little of that hahah. And with me doing sport and sweating a lot--- hmm.

Actually since I upped my salt intake I sweat a lot less! And it feels like my sweat cools me down way more.
I notice a bit more breathing drive.

I need to say, that I feel best on potassium + magnesium + sodium. Definitely better than only potassium + sodium or potassium + magnesium.

 

[Orion]

I need to say, that I feel best on potassium + magnesium + sodium.

Nice, what doses are you using throughout the day?