Re: Mitochondrial problems.
<r><QUOTE author="HerrFisch" post_id="1227" time="1507901471" user_id="114"><s>
HerrFisch post_id=1227 time=1507901471 user_id=114 said:
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@mattyb <br/>
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Could it be like this?<br/>
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There are 4 Ways. 2 of those you can live with .<br/>
(mito count based on body needs or activity)<br/>
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Way1: too high mito count (high fission) = UC <br/>
Way2: too low mito count = Urgency<br/>
Way3: good mito count / normal fission = perfect <br/>
Way4: low mito count / low fission (because mito count in general is kept low) = remission<br/>
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In way2 with too low mito count if you demand energy from the body with sports and lots of food. I think it is just not capable of doing that. That would only be possible with good mito count. (therefore pyruvate cant be used up? ->lactate ->acidosis)<br/>
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I think what caffeine, palmitic acid, smoking does is pushing my metabolism up. (mito count). Right now Im feeling UC coming slightly back and my urgency is pretty good. <br/>
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I think I was in Way4 for some time when I was younger. I was always eating very litte. Now with more need for energy? the mito count is not fitting to my daily "lifestyle". It fits that my problems started with increasing food intake without beeing hungry.<br/>
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With this thoughts in Way1 / Ulcerative colitis the need for energy / resources / detoxifier / vitamins etc is increased (and more wasteproducts etc) But the body cant do that. Its just too fast metabolism. And too fast increasing one.<br/>
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So I want normal mito count which stays in place. Low fission = metabolism wont upregulate that fast. <br/>
So is it downregulation of metabolims whats missing in UC? (mitochondrial fusion) Or fission is just to high.
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Yeah you're definitely getting it!<br/>
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I like to think of things as part of stages or a cycle, so here is a pretty clear way to think about it.<br/>
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1. Original tissue injury (could be from anything - radiation, virus, toxin, etc.)<br/>
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2. Mitochondrial Fission begins in the affected tissue. Metabolism is increased in that tissue - minor to no symptoms yet. Metabolism in all other tissues remains normal.<br/>
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3. Buildup of toxic byproducts of metabolism, lack of neutralizers (SOD, catalase, etc.) - symptoms begin flaring up<br/>
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4. Immune system reacts to damage, antibodies are made, inflammation is at a peak - primary disease symptoms are at their worse. Cells are being damaged from toxic metabolic byproducts and toxic secretions from the immune system who thinks there's a pathogen causing the damage.<br/>
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5. Body releases anti-inflammatory cascade (e.g. cortisol, IL-10) to try and dampen immune response. The anti-inflammatory response helps decrease damage from the immune system, but the cortisol actually increases mitochondrial fission. Symptoms may be stagnant or improve slightly at this point.<br/>
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6. All cells become resistant to glucocorticoids (cortisol) after prolonged exposure. Body's glucose stores may be exhausted as well from enhanced immune activity, which consumes tons of glucose. The lack of stimulation from glucocorticoids and lack of glucose for energy causes metabolism to decrease in all tissues. Cells in the affected tissue reduce rate of fission, and metabolic rate in the affected tissue returns to baseline. Metabolic rate in all other healthy tissues is below baseline because they were normal beforehand. Primary symptoms go away, main disease goes into remission. But other symptoms like fatigue and lack of energy may begin to crop up. <br/>
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7. At this point, the disease is in remission. It may flare up again if there is another injury to the tissue (more radiation, toxins, stress, etc.). It may also flare up in response to increased energy load (if the person eats a ton). If either or both of these happen, the cycle restarts itself and we go back to stage 1.<br/>
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So you can see we need to play into remission. Gotta go low energy for a prolonged period of time to promote mitochondrial fusion and intracellular reorganization. Keep energy low to keep the immune system quiet. And keep energy low to resensitize the cells to cortisol (remember - cells are sensitive to hormones based off of need, not just exposure). That will break the cycle and send people into remission for a much longer period of time, and possibly even cure them (as long as they limit exposure to the things that caused the damage in the first place - like radiation, stress, toxins, virus/bacteria, etc, or find a way to protect themselves from those things if exposed).</r>
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