Ulcerative Colitis / IBD

[Helen]

One of the reviews I found.

I have posted about this several times...taking histidine literally gave me my life back. I still have to take it every day to keep down the allergic responses (food, pollen, chemicals, etc) but the amount I take varies according to my total load.

The two brands I prefer are Montiff and Jo-Mar. You can find both on the internet. If you take histidine you do need about 15-20mg zinc for every 500mg of histidine.

Eddie, while high histamine can be a problem, especially in certain types of mental illness, there's a paradoxical effect in that the higher your blood levels of histidine, the slower the mast cells are to release histamines. For the conversion to take place it also requires zinc and B6, so for that reason I suggest that people keep their zinc levels adequate, but not high and avoid the histidine supplements that include B6 unless they are trying to use it to increase histamines (this is another topic, but it affects sexual function).

I have been using histidine for about 15 years now and even wrote a paper on it for my sports nutrition certification. It's an amazingly overlooked amino acid...many of my clients with IBS improved dramatically, too, since it decreases cytokine production in the intestines and increases calcium absorption which slows smooth muscle contraction.

I took Beta alanine as pre workout 2 years ago. 5g almost every 2. day. Beta alanine lowers taurine by hypertaurinuria - loss of taurine in the urine. Taurine was the first thing to help me.

Maybe the other player is histidine.
So Taurine was missing to excrete copper.
+ And histidine is missing for stomach acid, therefore lowering bile even more
+ use of copper is lowered by low levels of histidine too.
+ high amounts of copper in pipes
+ low metabolism (UC) less use for copper

Beta alanine could be a problem in carnosine for taurine, true.

 

[mattyb]

I see tons of people taking it for low blood histamine and allergies when I look it up. That is different.

This is different from IBS. In many people with IBS you have high histamine, which means receptors are likely low or normal already. I have not heard from Herr that he has chronic hives or rhinitus or anything like that. Peripheral sensitivity is probably not an issue if that is the case.

The histamine production is not a problem just because of it's interaction with histamine receptors. The histamine itself is a signalling agent for many pro-inflammatory interleukins on T-cells, it's immunosuppressive abilities don't kick in either in IBS/UC/Crohn's because there is also too much stimulation from the tissue damage that is on-going - otherwise histamine acts as an end to the signalling cascade of inflammation. I don't see how increasing histidine intake would lower histamine production, which is what we need to lower. You fix the underlying problems to fix the high histamine, it's the only thing that will bring it down.

You can try out histidine to see if it makes things worse or better. But I have strong suspicion that it would make things worse in UC/IBD, particularly during a flare up.

 

[Helen]

I see tons of people taking it for low blood histamine and allergies when I look it up. That is different.

This is different from IBS. In many people with IBS you have high histamine, which means receptors are likely low or normal already. I have not heard from Herr that he has hives or rhinitus or anything like that. Peripheral sensitivity is probably not an issue if that is the case.

The histamine production is not a problem just because of it's interaction with histamine receptors. The histamine itself is a signalling agent for many pro-inflammatory interleukins on T-cells, it's immunosuppressive abilities don't kick in either in IBS/UC/Crohn's because there is also too much stimulation from the tissue damage that is on-going - otherwise histamine acts as an end to the signalling cascade of inflammation. I don't see how increasing histidine intake would lower histamine production, which is what we need to lower. You fix the underlying problems to fix the high histamine, it's the only thing that will bring it down.

You can try out histidine to see if it makes things worse or better. But I have strong suspicion that it would make things worse in UC/IBD, particularly during a flare up.

Did you read the post I just posted with a a pracitioner woman who treats IBS

 

[Helen]

Re: Ulcerative Colitis / IBD
Edit Report this post Quote
Post by gbolduev » Mon Dec 04, 2017 5:20 pm

One of the reviews I found.

I have posted about this several times...taking histidine literally gave me my life back. I still have to take it every day to keep down the allergic responses (food, pollen, chemicals, etc) but the amount I take varies according to my total load.

The two brands I prefer are Montiff and Jo-Mar. You can find both on the internet. If you take histidine you do need about 15-20mg zinc for every 500mg of histidine.

Eddie, while high histamine can be a problem, especially in certain types of mental illness, there's a paradoxical effect in that the higher your blood levels of histidine, the slower the mast cells are to release histamines. For the conversion to take place it also requires zinc and B6, so for that reason I suggest that people keep their zinc levels adequate, but not high and avoid the histidine supplements that include B6 unless they are trying to use it to increase histamines (this is another topic, but it affects sexual function).

I have been using histidine for about 15 years now and even wrote a paper on it for my sports nutrition certification. It's an amazingly overlooked amino acid...many of my clients with IBS improved dramatically, too, since it decreases cytokine production in the intestines and increases calcium absorption which slows smooth muscle contraction.

 

[mattyb]

My own case is much more of what you are describing gbold. Increasing stomach acid, lots of histidine rich vegetables, and then subsequent high protein intake completely got rid of my hives. I had peripheral sensitivity and transient alkalosis. Too much calcium exchange at the histamine-Ca2+ exchange, too much sensitivity release histamine.

 

[mattyb]

Okay, that is great to see some people have success. But Herr has HIGH histamine and no chronic hives/rhinitus. Why would we assume peripheral sensitivity is up in that case? Much more likely the cause is the high histamine.

I mean, whatever, he can try. It will help or it will hurt. One way or another he will find out quickly.

 

[Helen]

Okay, that is great to see some people have success. But Herr has HIGH histamine and no chronic hives/rhinitus. Why would we assume peripheral sensitivity is up in that case? Much more likely the cause is the high histamine.

I mean, whatever, he can try. It will help or it will hurt. One way or another he will find out quickly.

We need to see. May be his DAO is not working.

Yeah we just need to try 2-3 things with him until it is gone.

 

[HerrFisch]

Okay, that is great to see some people have success. But Herr has HIGH histamine and no chronic hives/rhinitus. Why would we assume peripheral sensitivity is up in that case? Much more likely the cause is the high histamine.

I mean, whatever, he can try. It will help or it will hurt. One way or another he will find out quickly.

When I scratch my skin even as little as possible, my skin swells and rises. I can paint things on my arm and it looks like cat scratches. But those hives dont appear without scratching.

I think histidine (or in my case carnosine) will help me with excess copper. And thats what I think is the case for my IBS.

"Copper toxicity is a major factor in irritable bowel syndrome because copper is excreted through the bile and certain things will cause you to suddenly dump copper. If you have been building up copper, anything that causes an increase in your metabolic rate will cause a copper dump and it comes out through the bile. If you are copper toxic and suddenly under a lot of stress, this may bring on an irritable bowel episode because suddenly excess copper is moving through your bowels and irritating them"

MY DAO is 16,3 u/ml an therefore in range (>10) [mention]gbolduev[/mention]
[My blood tests are on page 9]

 

[mattyb]

I think this is just like the PFS thing - we have two cases, one with high serum ligands and low/normal receptors or high receptor and low serum ligands.

I think the high histamine is pointing in the direction that Herr may be high serum + low/normal receptor. His DAO is normal. HCl doesn't really help. I've heard no complaints about sex drive. By the sounds of it no spontaneous hives (receptors aren't oversensitive), but does have dermatographia (receptors are functioning normally, just too much histamine around when there is stimulation).

Seriously, my case was so obviously low serum high receptor. I had low DAO, which I treated with pea shoots (which contain DAO), and then ultimately fixed with acidifying stomach and fixing transient alkalosis. My sex drive, although never horrible, certainly got more active once I fixed my hives and digestions issues. I probably could have taken histidine and improved dramatically. I just got the histidine on the back end when I increased protein intake after I could actually digest it properly.

 

[Helen]

I think this is just like the PFS thing - we have two cases, one with high serum ligands and low/normal receptors or high receptor and low serum ligands.

I think the high histamine is pointing in the direction that Herr may be high serum + low/normal receptor. His DAO is normal. HCl doesn't really help. I've heard no complaints about sex drive. By the sounds of it no spontaneous hives (receptors aren't oversensitive), but does have dermatographia (receptors are functioning normally, just too much histamine around when there is stimulation).

Seriously, my case was so obviously low serum high receptor. I had low DAO, which I treated with pea shoots (which contain DAO), and then ultimately fixed with acidifying stomach and fixing transient alkalosis. My sex drive, although never horrible, certainly got more active once I fixed my hives and digestions issues. I probably could have taken histidine and improved dramatically. I just got the histidine on the back end when I increased protein intake after I could actually digest it properly.

Matty you did all this with food, right.

Can you outline your protocol for this with food or whatever you used, to we can rec this to people. As one case.

 

[mattyb]

Matty you did all this with food, right.

Can you outline your protocol for this with food or whatever you used, to we can rec this to people. As one case.

Food and habits. I just outlined it all. Check it out.

 

[HerrFisch]

Histidine for hemoglobin, for working cortisol and glutathione.

Why does everything that [mention]gbolduev[/mention] writes always kind of fits on UC ?

UC is mostly low cortisol. Low glutathione and apparently histidine levels predicts UC relapse.
It pretty much correlates with CRP and TNFalpha. Dont know what that means yet though.

correlation but not causation?

 

[Helen]

Histidine for hemoglobin, for working cortisol and glutathione.

Why does everything that @gbolduev writes always kind of fits on UC ?

UC is mostly low cortisol. Low glutathione and apparently histidine levels predicts UC relapse.
It pretty much correlates with CRP and TNFalpha. Dont know what that means yet though.

correlation but not causation?

Low cortisol since it burned out, no protein to create it. it was high at the first alarm stage.

 

[Helen]

Histidine for hemoglobin, for working cortisol and glutathione.

Why does everything that @gbolduev writes always kind of fits on UC ?

UC is mostly low cortisol. Low glutathione and apparently histidine levels predicts UC relapse.
It pretty much correlates with CRP and TNFalpha. Dont know what that means yet though.

correlation but not causation?

We should also look at the possibility of Histidinemia in your case, if you have high histamines. and stuff

 

[HerrFisch]

We should also look at the possibility of Histidinemia in your case, if you have high histamines. and stuff

Hm only possible through blood or urine tests right?

On RPF many had succes with Cyproheptadine for all kinds of IBS.

 

[Helen]

We should also look at the possibility of Histidinemia in your case, if you have high histamines. and stuff

Hm only possible through blood or urine tests right?

On RPF many had succes with Cyproheptadine for all kinds of IBS.

Well anti histamine would do it LOL, but it sedates you . And you get fat.

I think we should look into histidine here. high or low. We need to figure it out. If high , then we have to look at ways to lowers hidistine .

May be taking high hidistine, forces the histidinase to work faster and that is how it works for IBS

Only trial and error here , if no labs.

 

[HerrFisch]

I think if I had high histidine levels, my copper in my HTA wouldnt be that high?

 

[mattyb]

I was on cypro for 3-4 months well over a year ago. It works great for digestion and for controlling hives, but the problem is it doesn't stick when you stop, everything just comes back. And you have to deal with fatigue. I did manage to lose weight on it though, but I was dieting at the time and working out 5 days a week - it wasn't easy. The weight loss I'm going through now has been much much easier comparatively - I don't really have to put any willpower into it and it's coming off slowly.

Cypro raises HCl, not sure of the mechanism, but I did find a study (paper textbook) from 1974 in my university library that tested this in animals and it showed an increase in stomach HCl.

I'm assuming the drug's nitrogen can bind a hydrogen and help retain protons in the blood that are eventually released freely into the blood stream when the drug is excreted. The body would compensate by retaining Cl- to balance charge, and then the retention of both could help with stomach acid synthesis. It has a nitrogen head and it has lots of double bonds capable of causing delocalization of electrons, which may be sufficient to bind the additional hydrogen.

 

[HerrFisch]

It has been demonstrated that inflammatory mediators such as leukotrienes and proinflammatory cytokines are involved in the pathogenesis of colitis in shigellosis. It has also been observed that ROS and nitric oxide (NO) are involved in the inflammatory response, and perhaps also involved in luminal secretion.

L-histidine is used in the management of chronic inflammatory conditions e.g. rheumatoid arthritis. It has been demonstrated that L-histidine inhibits formation of ecosanoids and it participates in anti-inflammatory activities as a scavenger of free radicals.

In vivo and in vitro experiments have shown that L-histidine inactivates molecular oxygen and hydroxyl radicals, and may thus prevent activation of inflammatory cells resulting in diminished production of inflammatory cytokines; this process may modify net transport of ions and water in acute colitis in shigellosis. L-histidine is believed to act directly with singlet oxygen by histidine imidazole ring. It might also prevent activation of chronic inflammatory cells through metal ions production of hydroxyradicals.

"A shows that histidine inhibited the hydrogen peroxide-induced secretion of IL-8 by Caco-2 cells in a dose-dependent manner, the inhibition rate reaching more than 48% at a concentration of 10 mM and over 78% inhibition at a concentration of 25 mM. "


Inhibition of 62.6% and 56.5% of IL-8 mRNA expression



L-Histidine: Inhibition of NO and Inhibition of ion secretion

L-histidine has been demonstrated to be a scavenger of ROS, more specifically it neutralizes hydroxy radical (OH-) and singlet oxygen (35). The neutralizing activity of L-histidine is achieved through interference of redox-reactions that produces OH- and a direct interaction on singlet oxygen (36). It is possible that L-histidine may inhibit increased secretion in acutely inflamed colon mucosa through RO molecules.





Inflammatory mediators such as prostaglandin, cytokines, prostacyclines and interleukins have been implicated in colitis but their roles have not been conclusively documented. In recent years, NO molecule has been implicated in vasodilatation that increases vascular permeability, and it also is cytotoxic to the gut mucosa (30;31). NOS and (ROS) are now considered important mediators of gut inflammation (32). LPS induces NO production from various cell types including macrophages, neutrophils and endothelial cells. Its excessive release during infections has linked to inflammation and inflammatory cascade. Much of this inflammation is related to the production of oxygen radical/super oxide (O2- ) and other ROS from acute inflammatory cells. Production of ROS is enhanced following priming by proinflammatory cytokines (33).

The fact that histidine can lower h2o2, ROS, and NO looks rather promising for histidine. [mention]mattyb[/mention]

Could it be that Histidine Carboxylase is upregulated? Things like NAC / Cortisol / Carnosine does seem to block this.
H. pylori increases HDC too.

I know that people with UC have problems with Vitamin b6. B6 does increase HDC.

Maybe Zinc + histidine. So there wont be free zinc which would increase histidine to histamine. ?

 

[Helen]

the only thing I am concerned with histidine about is its reaction with oxygen. Most people have hypoxia. Wouldn't that decrease oxygen bioavailability even more?