I see you're struggling so I'm gonna give you my own personal experience since I basically had to solve the copper toxicity problem twice.
I'm not pushing anything on you and you should be sceptical about anything you read.
My post here is just to give you my rationalization for my own personal successes and failures in dealing with copper.
My case is very simillar to PFS but not quite. I got sick in 2015 after eating very large amount of stinging nettle.
Beta-sitosterol in nettle and saw palmetto is basically a mild finasteride but I consumed a lot of it.
Copper toxicity was never the root problem for me but it was the biggest consequence.
The first time I almost solved this problem was during the first cycle of this forum in 2018/2019.
What I did back then was I drank Histidine-HCL around 400-500 grams in the span of 2 months and I got the copper skin shedding effect.
Althought I was shedding a lot of copper from my skin I was still very sick until I took manganese for 2 weeks in the end of 2018.
After a few cycles of zinc/manganese by health condition and digestion skyrocketed from 30% to like 70%.
But I was still kinda ignorant about these mechanics back then and basically stopped taking histidine and manganese for 5 years.
My condition didn't improve above that point. It was just very slowly sliding back. I was just enjoying biking, swimming and gaming thinking I was gonna improve naturally after that point.
But I didn't make any improvements for a while and started doing hormonal experiments which brought me nowhere.
Two years ago I stumbled on
The Copper Revolution and basically convinced myself I depleted my copper. Stupidest thing I've done lol.
I began taking 10mg copper everyday for like 2-3 months and then a lot of EDTA for chelating zinc. I was feeling very good initially but I fucked myself a bit.
Got inflamed gums, cavities and lost wisdom tooths because of this.
Luckily this year I got my senses back and refilled on zinc and manganese and stepped on the histidine again.
I consumed around 2 kilograms of histidine in the span of 3 months (HCL and base histidine. 1kg of each).
I was taking 3-4 tablespoons of histidine per day and on the 2nd week the copper shedding from the skin started and it lasted for more than 2 months.
Here's a video I made of how it looks like:
I basically went through this shedding multiple hours a days for over 2 months. So much black stuff was coming out of my skin it was insane.
The more I shedded the more my health and digestion improved. It was very bumpy initially because it made me so exhausted every day but its the best thing I've ever done for my health.
Carnosine is useful but you cant rely on it. Your brain is gonna get fucked up with beta-alanine on your 2nd week if this is your only histidine source.
After going through all this if someone tells me bile flow is how the body fixes copper toxicity I'm gonna laugh in his face lol.
With bile you can only get rid of a few milligrams of copper per day. From the skin you can detox more than 10-15mg per day.
And how do you expect to get bile flowing with no histidine and when B6 and folate are offline?
You can't really force it since if you take b6 active and methylfolate they work for a few hours and then you peed them out. Methylation is inhibited on purpose.
The body shuts it down since both of them break down histidine.
B6 makes histamine out of it and folate makes glutamate out of it. SAM-e also breaks down intracellular histamine.
No bile flow in copper toxicity is not a mistake. It is by design to save histidine.
Only after you clear out copper from liver and brain, your body asks for b2, b6 and folic acid and your methylation starts going up and it makes pancreatic enzymes and bile, not before.
Take from this post what you will. As I said I'm not pushing anything, just sharing my story.
The past few months have been the first time in 9 years I don't have to take digestive enzymes with meals and energy is great.