RU + Progesterone Cycle (PFS, PSSD)

[Goose12]

I definitely had a new all time high while on my prog ru cycle, that I still haven't reached since.

I think I would have had more of it stick if I would have done low dose ru instead of 50mgs. I think 5 mg would be better so only prog is blocked.

 

[bruschi11]

I read somewhere that men only make like 0.1mg of prog daily. So we are doing something very high with 5mg-10mg.

And it’s causing really shitty fatigue in me and I know @Goose12 had to abort prog due to the fatigue as well.

Maybe next time run prog at just 1 or 2 mg. @brongfogboy wrote on PH a few years back that 1mg did him well at times. I remember my last prog cycle I was doing better fatigue wise and even libido wise at lower doses at the end of they cycle while tapering.

Tomorrow I’ll use only 1 or 2mg. I crashed with fatigue pretty bad at end of day. Very stressful day for me. Had a bad electrolute crash that @Slayo mentions (bright lights, thirst, frequent urination, sound sensitivity, fatigue).

Might be good idea for you @Goose12 next time. Just do the RU followed by 1-2mg prog daily for the full say 10-14 days take 4 off then repeat with prog at the low dose.

 

[Jack17]

Good idea to experiment with lower progesterone doses. Failures may be related to too much progesterone. It's hard to estimate dose. Today I tried a quarter pump to get 5mg, I think. Tomorrow I'll try for 2.5mg or 1/8th of a pump. I don't typically get fatigued from progesterone but today mild fatigue/ drop in mood right after I did the progesterone.

 

[bruschi11]

I'm going to drop prog tomorrow. It will have been 10 days overall- 7 of which post RU at 5-10mg.

I will be taking 4 days off and then moving to 1 drop daily so it will be around 1.8mg I believe.

 

[Area-1255]

I definitely had a new all time high while on my prog ru cycle, that I still haven't reached since.

I think I would have had more of it stick if I would have done low dose ru instead of 50mgs. I think 5 mg would be better so only prog is blocked.

Interesting mate! Which one do you think is having a greater effect on you?

 

[Goose12]

Interesting mate! Which one do you think is having a greater effect on you?

I thinks it's the combination. Prog inhibits alpha reductase, which allows beta reductase to be upregulated. And at some time during cycle you take ru to make prog receptors more sensative, and ru works better in the presence of prog.

I have done 5 cycles of ru. I have noticed high dose ru cycles (50mgs) block prog and cortisol while lower dose (5mgs) only block prog, similar to ella. This has also been proven in studies and pointed out by @IHateFin .

On higher dose cycles I noticed it really slows my metabolism down and increases cfs but 2 to 3 weeks after my cycle my metabolism is greatly increased and cfs is reduced from baseline. I have mentioned it many time but ru helped with all pfs sides to an extent but now that my cortisol has normalized I havent received any more benifits from high dose ru.

Low dose ru and ella seems to have a greater effect on me now that my cortisol is under control. Some of the main benifits I have received so far are a return of oily skin which is a good thing, body oder, and testicles have returned to normal ( before they were always rock hard). During and directly post cycle I don't notice any effect on my metabolism or increase in cfs.

I am surprised more people with pfs dont try ru. The addition of prog just makes it better.

 

[Chapman]

I think the only reason is that's it's quite hard to get hold of and pretty expensive, but clearly it works as seemingly no one has had a bad reaction from it who has pfs!

 

[Chapman]

@Goose12 are you still running r andro as well?

 

[Jack17]

Interesting. It seems like several with PFS have CFS. The cause of CFS is unclear and I know a lot of research is focused at finding some pathogen. Some believe it's a result of a virus from the herpes family. Antivirals seem to help but this mechanism may be completely off base and in fact related to neurohormonal disregulation. And this problem is what's proposed for PFS. Seems like there has to be a connection, IMO.

 

[Goose12]

@Goose12 are you still running r andro as well?

I am on androhard from Muscle Gelz right now. I waited almost 3 weeks after my ru and prog cycle and jumped androhard, it's r andro and epi andro.

On my first cycle of r andro I added androhard half way through. All together I ran it for 4 weeks. On my first cycle I had increased vascularity, harder erections, incteased ejaculate, extreme hunger, and terrible fatigue. I didn't notice any increase in labido like I was hoping. On the snap back erection quality and ejaculate were slightly improved, and pfs anxiety decreased by 70 or 80%. I started to feel like a normal person.

This cycle is stronger. I am feeling alpha all the time and the start of some solid labido, and it's been less than a week. It took almost two weeks to feel anything on my first cycle.

 

[Jack17]

I'm going to drop prog tomorrow. It will have been 10 days overall- 7 of which post RU at 5-10mg.

I will be taking 4 days off and then moving to 1 drop daily so it will be around 1.8mg I believe.

Still feeling pretty good today. I'm trying not to overstate the benefit from this protocol but I'd say I'm 80-90% better. I started progesterone yesterday at 5 mg and planning today at 2.5mg. I've been feeling good for two solid weeks now. No significant drop off except last weekend there was a slight drop but better by Monday. 3 or so weeks ago I'd say I was like 30-40% of normal.

 

[Jack17]

I am on androhard from Muscle Gelz right now. I waited almost 3 weeks after my ru and prog cycle and jumped androhard, it's r andro and epi andro.

On my first cycle of r andro I added androhard half way through. All together I ran it for 4 weeks. On my first cycle I had increased vascularity, harder erections, incteased ejaculate, extreme hunger, and terrible fatigue. I didn't notice any increase in labido like I was hoping. On the snap back erection quality and ejaculate were slightly improved, and pfs anxiety decreased by 70 or 80%. I started to feel like a normal person.

This cycle is stronger. I am feeling alpha all the time and the start of some solid labido, and it's been less than a week. It took almost two weeks to feel anything on my first cycle.

Hi...How much RU are/have you been taking? How often do you do that? Can I ask why you stopped progesterone and started Androhard/ randro? I did three days of Ella and then started Randro beginning of February. I had tried Randro before with some benefit but typically only would feel positive results for a couple days. After Ella, totally felt great for like several days but then it faded away. My point is that for me the progesterone cycle (so far) we are doing seems much more beneficial.

 

[vicecaz]

The results you guys got with RU + prog are really interesting! congrats
Hope it sticks and gets even better
I might try it in the following weeks/months depending on the outcome of my current protocol

There hasn't been bad experiences with RU so far which is reassuring too !

 

[Goose12]

Hi...How much RU are/have you been taking? How often do you do that? Can I ask why you stopped progesterone and started Androhard/ randro? I did three days of Ella and then started Randro beginning of February. I had tried Randro before with some benefit but typically only would feel positive results for a couple days. After Ella, totally felt great for like several days but then it faded away. My point is that for me the progesterone cycle (so far) we are doing seems much more beneficial.

I have ran an ru cycle once a month since October. I have done 5 cycles including my last one with prog in February. My first cycle was 50mgs for 3 days, second was 25mgs for 3 days, third was 5mgs for 4 days, 4th was 50mgs for 3 days, and fith was 50mgs for 3 days while taking prog for 6. I also tried a 1 day of 100mgs of ru and didn't notice anything and jumped on ella for 5 days at 6mgs sometime between ru cycles.

I would like to run ru again ( I have 50mgs left) with prog but I feel like I need a break from ru, and I am enjoying my snap from ru of a fast metabolism and no cfs.

I wanted to run randro again to try an hit this pfs from another angle. My experience so far has been this is like a puzzle and we need to work on this in many different ways. I also had a good experience from my the snap back from my first cycle and I am curious how I will react to this one. While on my first cycle things weren't that great but the snap back was beneficial.

If I run prog and gain I think I will do it similar to you with 10 to 14 days at 5mgs of prog and 5mgs for 3 days of RU on my off days of prog or my last 3 days of prog.

 

[Jack17]

I have ran an ru cycle once a month since October. I have done 5 cycles including my last one with prog in February. My first cycle was 50mgs for 3 days, second was 25mgs for 3 days, third was 5mgs for 4 days, 4th was 50mgs for 3 days, and fith was 50mgs for 3 days while taking prog for 6. I also tried a 1 day of 100mgs of ru and didn't notice anything and jumped on ella for 5 days at 6mgs sometime between ru cycles.

I would like to run ru again ( I have 50mgs left) with prog but I feel like I need a break from ru, and I am enjoying my snap from ru of a fast metabolism and no cfs.

I wanted to run randro again to try an hit this pfs from another angle. My experience so far has been this is like a puzzle and we need to work on this in many different ways. I also had a good experience from my the snap back from my first cycle and I am curious how I will react to this one. While on my first cycle things weren't that great but the snap back was beneficial.

If I run prog and gain I think I will do it similar to you with 10 to 14 days at 5mgs of prog and 5mgs for 3 days of RU on my off days of prog or my last 3 days of prog.

I was just reviewing my notes, as this gets complicated but I did RU 10mg for three days end for Feb and I actually started (forgot) Randro four days later. I took it for 2 days and didn't notice anything, as I really noticed an effect( but only lasted couple days) after Ella. Anyway, that is when I joined this board. I noticed guys were using Progesterone after RU and I thought that made a lot of sense. I started progesterone 7 days after stopping RU. I stopped the Randro (only took it for two days.) To be honest for me Randro makes you feel a little better but sexual side effects only would improve for maybe one to two days then fad, if at all. Two days after starting progesterone I really noticed a huge improvement. So for the past 2 solid weeks I've been feeling really good. Totally good libido, morning wood normal, good mood and normal thinking. I thought I might add RU during the four day off period but I waited and had a good snap back and then restarted progesterone at a lower dose two days ago. I'd really like more guys to consider following this protocol. I think it's made a huge difference and I don't really see any other protocols that have made such a dramatic improvement, IMO.

 

[Goose12]

I was just reviewing my notes, as this gets complicated but I did RU 10mg for three days end for Feb and I actually started (forgot) Randro four days later. I took it for 2 days and didn't notice anything, as I really noticed an effect( but only lasted couple days) after Ella. Anyway, that is when I joined this board. I noticed guys were using Progesterone after RU and I thought that made a lot of sense. I started progesterone 7 days after stopping RU. I stopped the Randro (only took it for two days.) To be honest for me Randro makes you feel a little better but sexual side effects only would improve for maybe one to two days then fad, if at all. Two days after starting progesterone I really noticed a huge improvement. So for the past 2 solid weeks I've been feeling really good. Totally good libido, morning wood normal, good mood and normal thinking. I thought I might add RU during the four day off period but I waited and had a good snap back and then restarted progesterone at a lower dose two days ago. I'd really like more guys to consider following this protocol. I think it's made a huge difference and I don't really see any other protocols that have made such a dramatic improvement, IMO.

That's great you have seen such dramatic improvements. What do you recommend for dosages and timing for prog ru cyclem

When I first tried ru I had really good inprovements in all areas and honestly it was like r andro times 3 and in a much shorter time but improvements were less and less each time. Add in prog to it helped but and lot of it didn't stick and lots improvements think it was because I took to much ru.

For randro to lead to any improvements you have to be on it for 4 to 6 weeks. The reason is to keep 5 alpha inhibited with randro andro while 5 beta is up regulated. It's one of the reasons why prog works because it's a strong 5 alpha reductase inhibitor.

It usually takes a week or two for randro andro andro to really kick in even for people with out pfs. Everybody is different but most of the forums I have read with people cycling andro it takes while to feel it. When I first took it I noticed some improvements in the first couple of 5ays alpha another wave of improvements after a week and another after 3 weeks.

 

[Jack17]

That's great you have seen such dramatic improvements. What do you recommend for dosages and timing for prog ru cyclem

When I first tried ru I had really good inprovements in all areas and honestly it was like r andro times 3 and in a much shorter time but improvements were less and less each time. Add in prog to it helped but and lot of it didn't stick and lots improvements think it was because I took to much ru.

For randro to lead to any improvements you have to be on it for 4 to 6 weeks. The reason is to keep 5 alpha inhibited with randro andro while 5 beta is up regulated. It's one of the reasons why prog works because it's a strong 5 alpha reductase inhibitor.

It usually takes a week or two for randro andro andro to really kick in even for people with out pfs. Everybody is different but most of the forums I have read with people cycling andro it takes while to feel it. When I first took it I noticed some improvements in the first couple of 5ays alpha another wave of improvements after a week and another after 3 weeks.

I took three days of RU est 10mg a day. Like five days later I started topical progesterone at 10mg for 10 days then stopped for 4 days then restarted at 2.5mg(est) It seems the protocol should be RU dosing, wait couple days for RU to lower and then start low dose progesterone for some period of time 7-10-14 days then stop. Wait four or so days and restart progesterone. The timing for another RU dose is unclear but maybe if the benefit or effect of progesterone is waning, then re-dose RU. I think there is some sort of tolerance that can occur to most treatments, so I decided not to re-dose RU on every off period of progesterone. I still feel 80-90% better. I'm very please with the results of this protocol and I have not felt even close to this level in the past 15months.

 

[Jack17]

Some drop off since Friday... Interesting that I was doing so well but past three day I'd say dropped from 80% or so down to 40% though hard to say for sure. I am 5 days back on progesterone. Might be from too much prolactin as I haven't been consistent with Selegiline or Inositol.

 

[MNK99]

My bad if this was addressed, @Jack17, do you mean that progress/percentage completion of your PFS was 80% but now it feels like 40%?
Or do you mean: That the gains from ru + prog were 80%, but now it's 40%?

-Edit: You'll pull through man. Keep it up, maybe there will be snap-back. Perhaps you're right about the prolactin, it would make sense.

 

[Jack17]

Oh... I meant I was feeling like 80% better and for some reason over past three days it's dropped to 40%. I think it could be prolactin but not sure.