What are examples of things that lower electrolytes?
ESTRONE VS ESTRADIOL RATIO as the cause of PFS and hairloss.
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I think he was talking about dehydration. Like for example coffee enema is great for detoxification, but can really dehydrate you.. Same with drinking a lot of pure water which will flush all your electrolytes from the body trough urine(especially sodium) and you will be dry like beef jerky.. That is probably most well known bullshit from everyone fitness people, doctors etc.. That you need to drink a lot of water for hydration. But in reality if you don't add elecrolytes to the water(especially sodium) then you just dehydrate your body.. A lot of people especially older die due to this when doctors tell them don't use salt(due to blood pressure) and drink a lot of water in the summer..
I’m getting ready to start the ARL program. Should I get my amino acids checked before buying all the recommended ARL supplements?
Well if you can have some test on amino acids for sure.. I would love to. But it is not available here.. But you can always take some good quality whey protein to making sure that you are having all essential aminos in undenatured/easy to digest form...
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L-Histidine has plenty of other benefits; it converts to L-Histidine which stimulates H2-receptors - releases cAMP/decreases platelet activity/release [1], boosts nitric oxide [2] and can increase Leydig Testosterone Synthesis [3]. Histamine H1-Receptors stimulate Nitric Oxide formation as well. Histamine plays a vital role in Male Fertility due to its localization in Human Gonads.
I'm curious. What specifically happens to people when they are just simply around mold? I once heard the same thing on a podcast but they didnt elaborate other than they said they can sense their estrogen levels get high enough to make women jealous.
@supernature do you understand that i have no money ? That this shit hit me way before i had the change to get a job because ii was very young ? I know this mold stuff very well, and i know that mold itself is not a problem, people that lived in place with very little humanity found they didn't react to mold, the problem is when mold is mixed with enviromental toxins, it creates toxins that are much much worse, for example you mix mold with silver and you get silver nanoparticles.
I have to convince my parents to rent me an appartment for some months, and i did it, in September they will rent me an appartment for 4-5 months, the problem is to find an enough safe appartment.
And i don't need to die to be dead, i'm already dead
I have to convince my parents to rent me an appartment for some months, and i did it, in September they will rent me an appartment for 4-5 months, the problem is to find an enough safe appartment.
And i don't need to die to be dead, i'm already dead
Mold increases estrogens a lot, but mine are normal.
I heard many women had crazy weight gain while exposed to mold, and many bodybuilders training in moldy gym weren't able to reach a good cut till they stopped their mold exposure at the gym
How much mold are we talkin' about? Walls laced with it or just small amounts?
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I was 'gonna say that's got to be like an abandoned make-shift gym or Owners just don't give a shit at all???
Aflac94
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Throughout this I kept thinking it feels like I'm a male going through a worse version of female menopause. Bad skin, can't sleep, can't exercise and early on I had the overheating all the time, anxiety, depression. Their estrogen and progesterone ratios get screwed and so did mine I guess with finasteride
supernature
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supernature
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Another pathway here could be the Kynurenic Acid pathway. Kynurenic Acid (KYNA or KYN) is a metabolite of L-Tryptophan and can block NMDA, AMPA and Kainate Gluamate receptors [1] "technically" conferring MILD neuroprotection but also can led to Psychosis and Delirium [2] - and its levels are ELEVATED in Schizophrenia [3] and given the fact Androgens can reduce this product of Tryptophan Metabolism; probably PFS sufferers as well [4]; which may explain the Cognitive Deficits in both conditions [5]. This pathway is also associated with (when activated) "fewer days alive" in the Critically Ill. ~Exposure to Kynurenic Acid in Adolescence produces Memory Deficits in Adulthood.~ Through many mechanisms, including Alpha-7-nicotinic-antagonism, Kynurenic Acid nails the Brain into Poor Cognitive Function, potentially bordering on Insanity.
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supernature
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It is all about FAD and NADPH. not just NADPH. they recycle glutathione . pyridoxine is activated by FAD or zinc. so it is about pyridoxine. this is why I give b1 and b2. and b6 This will convert tryptophan to niacin with zero problems, chelate iron( if you have it high) , retain potassium and increase NADPH.
NADPH oxidase will be activated when there is no potassium. So potassium is important along with magnesium
In chizo there is high dopamine, since ascorbate is not recycled by glutathione. You need Fad and NADPH for that.
It is all about the balance of FAD with NADPH. One makes another work.
if there is no NADPH , FAD wont be available either, since NADPH oxidase = FAD enzyme.
Riboflavin + NADPH= reduced ribo
And b6 active( which is fad or zinc) wont be working if there is no histidine, or there is high histamine. Since they convert histidine into histamine.
This is why B2 is needed to convert folates into methylfolate. since it activates b6. Methylfolate will lower histamine, and if you have low histamine already. this will lower your copper.
And if you give b2 without b1. you will increase histamines and have crazy intercellular histamines. And lower intracellular histamine since b2 is also in DAO ( since dao needs active b6 which is b2 and zinc)
This is why in really bad histamine cases, you give b2 with methylfolate for a short time. along with all other bs and b1 and then you take away methylfolate. Methylfolate is to clear intercellular histamines basically substituting b1, and to speed up B2 availability which increases active b6 to produce more histamine and methylfolate.
We were talking about the markers how to see NADPH activity , but we need to look for the markers to see FAD and NADPH activity.
but overall, IDO TDO pathway is what matters also, some have it activated and some have the problems to activate it. And it is all about iron b2 ( b6) for this pathway.
To make NADPH you need NAD, pentose and phosphorus. to make NAD you need iron and b2.( b6)
But there are 100s of regulations of all this stuff, that is why it is so hard to lift up, since if you dont account for one connected thing, it does not work.
Androgens induce NADPH oxidase. since androgens lower potassium. After looking at @Yura it is understandable why he saw crazy oxidives stress and losing his elastic tissue. May be even heart tissue. SO androgens are not good IMO.
This is why we need to look at the balance of B vitamins here. And see which ones we are missing.
Actually in pyroluria they give zinc and b6. Those are lost in the urine. And people are wondering why are those lost in the urine.
Since glutathione is not working. And zinc and b6 will make histamine. And there is no methyl folate without glutathione to get rid of histamine intercellular.
So we have 2 histamines intra and intercelluar. intra is taken care off by DAO which is copper and active b6 and histidine.
and intercellular is taken care of by methylfolate. So obviously for the methylation to work, you need to have histamine made) And some blocks in the methylation will be because of lack of histidine also.
B6 can be activated by B2 or zinc. 2 different enzymes. So If you have low methylfolate because of low FAD. then you cant get rid of histamine. And body has to lower zinc and b6 and puts it into the urine.( and this is called pyroluria). since if it does not , then people have anxiety , since their intercellur histamines are too high. These people never really recover on zinc and b6. Since that will never increase their FAD.
SO I would assume it is more of a FAD( NAPDH) deficiency which causes zinc and B6 to be out, in pyroluria.
Hoffer cured schizo with huge doses of niacin. Basically lowering intercellular histamines .( which is what schizo is) dopamine thing is a part of it. the oxidative stress kills cerebellum , it gets smaller and smaller and smaller. So schizo is basically oxidative stress disease
And it kills cerebellum by oxidation and actually there isnt enough NDMA action there which ruins GABA reception. And slowly gaba goes down. since GABA itself ruins KCC2 transporter I would assume.
The role of the cerebellum in schizophrenia: from cognition to molecular pathways
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To have androgens working properly you need to have a balance, since only the balance has the biggest energy output. High testosterone gives you nothing. You will be powerless out of breath person.
Never understood why would anyone take steroids. The goal is to achieve max power. Max power is not testosterone. But balanced oxidation and respiration, Only in that case you will have max gains, max power , max health.
If anyone ever takes testosterone. It needs to be taken with progesterone. that is a cycle for anyone who wants to be on juice. Or DHT with progesterone.
Never understood why would anyone take steroids. The goal is to achieve max power. Max power is not testosterone. But balanced oxidation and respiration, Only in that case you will have max gains, max power , max health.
If anyone ever takes testosterone. It needs to be taken with progesterone. that is a cycle for anyone who wants to be on juice. Or DHT with progesterone.
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What about steroids that don't aromatize instead of testosterone (i.e. superdrol/methasterone.)? For example, we talked about DHT + estrogen can help reverse PFS but it won't stick when you go off it, but what about taking a steroid that doesn't aromatize or it blocks the ER so then when you come off it your estrogen will rise naturally causing DHT to become sensitive again? When I took superdrol, I didn't take anything for PCT so my estrogen was not blocked post cycle which is why my estrogen was probably high which triggered my DHT high or became super DHT sensitive, but hair fell out. Also, my actual on cycle time was short just shy of four weeks. I can't speak much to personal experiences from other steroids since superdrol was the first one I took which triggered hair loss for me so anything after that my hair was already shedding.
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I am not talking about taking testosterone and progesterone for PFS. or taking any steroids here. I just mentioned about the cycle for normal people if someone ever decides to take do steroids.
DHT and estradiol, just by pass the missing NADPH. And only for people with low DHT and low estradiol. They fix nothing. YOu just give 2 hormones which are missing.
Without NADPH you simply dont make Estradiol or DHT. Look at the chart. both of them are made with NADPH. You have high estrone. and low dht. Since estrone is converted into estradiol by NADPH. And testosterone is created and converted to DHT by NADPH.
This is one case of PFS. Low testosterone normal estradiol, high estrone. low or normal DHT.
In another case, we have high normal testosterone, high normal dht, and probably high estradiol.
So I have no idea which case you are Tubz. You need to do some bloods.
If you took superdrol, and it does not aromatize. It should increase NADPH oxidase. And it does since it lowers LH. How would you have high estrogen.
WE have 2 cases of people here
WE have a group with high DHT high estradiol. high testosterone .yes that group might benefit from going on steroid cycle. Will it fix them? Not exactly. Since from one deficiency , now you create 2 . they were missing FAD. now you are trying for them to be missing NADPH also. So FAD vs NADPH balance balances. but both are low.
This is the same as accuntane and finasteride. If you give fin for one body chemistry. you will unbalance FAD and NADPH, so now you can give accutane to that person, and FAD and NADPH will be even. But BOTH LOW.
Same with Accutane people. they have crazy acne, which is def in fat metabolism. utilization.. They take accutane. Boom , they get rid of NADPH. This turns off all sugar metabolism. Now they have to run on FAD. Boom acne goes away, but hairloss and other stuff HELLO.
Same as with steroids. You take DHT and you create , the deficiency in one vitamin. Now most people go and look for some stupid hormones and other stuff to balance it. and they create the def in another nutrient and now they are happy they fixed a problem, but they got 3 more problems.
I dont think it is about sensitivities or receptors here. I think it is about chemical balance. All the receptors are nothing but minerals. vitamins interactions.
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