Resveratrol to increase estrogen sensitivity

[JDD]

It's been mentioned that resveratrol should be cycled to increase estrogen sensitivity. Any idea how long you should cycle off for before taking again?

 

[Canari]

JDD, sorry, I have no idea why your post got "glued" to my post I moved, about HCl! When I tried to move yours back to the thread I thought it belonged to, there was no way... Then I thought there was no topic gathering all about resveratrol, and I thought it was better as a new thread than with HCl...

So, there are so many search pages about resveratrol, I do my mea culpa and copy...

No answer to your question, just the suggestion that all those who try should notify what they try and the amount.

Resveratrol

According to Peat, Reseveratrol being a stilbene, is an estrogen. Some also call it an SERM. However, on 500mg 98% pure resveratrol I experienced a complete lack of water retention, and joint pains, particularly in my knees, which according to bodybuilder lore is a clinching sign of tanking estrogen too low. My libido and EQ was also exceptionally good at the time, all seemingly on account of resveratrol. I stopped taking it a few years ago after coming under the spell of Peat's aversion to estrogen. The effects of resveratrol are somewhat reminiscent of one of gbolduev's suggestions, i.e., taking estrogen+DHT in order to reverse PFS like symptoms. Apparently, there is also some research showing that estrogen+DHT combination works. Could resveratrol be a viable contrarian endocrinology approach to solving PFS. @gbolduev?

estrogenic stuff like resveratrol, phytoestrogens. they lower your copper. So this lowers your base estrogen level.
You can read about it. arotamatase is copper dependant . Resveratrol is estrogen, it chelates copper

And in alkalosis your potassium gets disregulated. And then you have similar progesterone problems.

I think to force out of PSSD, you need to methylate. I would assume this will force the body to go into met acidosis and potassium gets back to normal. then you get off and you are fine.
I never tried it. But I would assume it will work. Make sure you use that thorne extra, since it does not have anything bad in it I checked and you can add resveratrol to it. copper deficiency is what responsible for demethylation.

taking progesterone chelates ZINC OUT and retains copper. Taking estrogen chelates copper. This is what resveratrol does , it is estrogen and it chelates copper.
Big difference between internal production and taking hormones from the outside.

this is where you mix things. Hormone high or low inside by your own production is based on the mineral level at a time. taking hormones from the outside will chelate that mineral. Estrogen chelates copper, copper is what MAO A runs on, if your copper goes down, less MAO A and more serotonin. So yes estrogen can work.

 

[Canari]

How much resveratrol did you take to lower your estrogen that much ?

500mg a day of 98% purity resverstrol daily.

Yeah, I too think the theory that progesterone/thyroid severely depleting precursors is quite plausible.

Also from gbolduev, Resveratrol might be something to experiment a cycle with:

"estrogenic stuff like resveratrol, phytoestrogens. they lower your copper. So this lowers your base estrogen level.

You can read about it. arotamatase is copper dependant . Resveratrol is estrogen, it chelates copper"

I mentioned using resveratrol plus dht, or estrogen plus dht. Resveratrol is estrogen. it is the same as using zinc plus copper pretty much. Only I doubt using estrogen with DHT will ever stick.

Zinc increases testosterone and DHT only when copper takes the pressure off the cortisol by tanking potassium and 5 alpha reductase2 goes up

I am still not sure if this will restore everthing. It should long term

Does carnosine replace resveratrol (cylcling) for those with high copper? Or can I use them together?

To Nina:

Have you tried out cold exposure?

I think resveratrol and beetroot supplements once every 3-4 days would be of benefit in your case, if my theory about post-surgical CFS being caused by mitochondrial uncouplers (NSAIDs and warfarin) is true. Resveratrol inhibits uncoupling, and beetroot supplements stimulate O2 uptake and metabolism/ATP synthesis.

 

[Canari]

Does carnosine replace resveratrol (cylcling) for those with high copper? Or can I use them together?

WUF

for you case, why dont you just jump on resveratrol and stay on it for a little while. You obviously have high free copper, which does not allow you to go back on. Since copper should never be taken without potassium and b2.

for some people copper helps. And for others resveratrol helps.

the ones with high estrogen needs to take care of their prolactin

If you feel bad on copper, try to increase estrogen signaling by resveratrol, it will chelate free copper and this will increase estrogen signaling

 

[Canari]

I’m confused. It’s stated that an increase in estrogen will increase libido. My estrogen is high above range (please see my log), my progesterone is in range and my prolactin is in range (low in range), yet my libido is virtually nothing. So what is wrong with me?
Also, resveratrol was suggested to me to help reduce Estrogen yet it appears resveratrol is being suggested here to increase Estrogen(?)

Gbold says there is a difference between being fixed and being balanced. Fixed means ‘take this and feel better’. Balanced means ‘come OFF of everything and feel better, you’re balanced’.

He himself said he is not balanced yet, just fixed...not sure if that has changed over the last week or so.

Take estrogen and dht and be ‘fixed’. Resveratrol plus haiduts 11-keto dht is like a miracle fix. All symptoms of pfs gone in 2 days. But does it balance me or does it make me worse once I come off???

He has said many times that it’s ultimately not as simple as just taking minerals.

On the other hand, zinc + mang was originally mentioned by him as a 2 month protocol to balance the body:
Lower venous co2, get co2 in to the cell, lower estrogen, chelate copper, optimise thyroid. Don’t think anyone has quite gotten that far yet in experimentation...

Anyone who wants to get fixed fast just go resveratrol plus dht route or just resveratrol.

I am still working on the mineral cure. I 'm close.

Sorry to bother Gbold.
But resveratrol seems to be an anti aromatase supplements from what I am reading in google.
Mybe the sourse is wrong.
Thanks

 

[Canari]

Is increasing estrogen signaling different from increasing estrogen? Is it ok for me to take resveratrol even when my Estrogen is already high?

I think gbolduev means to increase estrogen with resveratrol to make receptors sensitive when snap back. But maybe I'm wrong

First result when I used google scholar and the search terms "resveratrol estrogen receptor". Google scholar is amazing. Never use anything else, other than textbooks, if you want to study/understand physiology. Just using a generic search engine is a waste of time.

http://www.pnas.org/content/94/25/14138.short

That's great, thanks..I didnt know.
By the way it seems to do both, increasing estrogens signaling and also to reduce aromatase.

No problem! Happy to help. Learning good search strategies is probably the most important thing to develop if you're into research nowadays.

Yes, that is no surprise. The body would downregulate estrogen synthesis because resveratrol increases sensitivity to estrogen. The body always wants to keep balance.

Is there a difference between Japanese knotweed or say grape resveratrol? I'm assuming they both would work

I don't know much about this stuff, but it looks like knotweed is higher in the active trans-resveratrol? Most studies use trans-resveratrol from what I've seen anyway, so it's probably a better bet.

 

[Canari]

It's been mentioned that resveratrol should be cycled to increase estrogen sensitivity. Any idea how long you should cycle off for before taking again?

Maybe your answer is here...

Is there any resveratrol protocol? It seems to be a safe and easy try, so I would like to commit myself to it. I used the search but coudn't find specific information. How much should I take? How often? How long? Has anyone got cured or at least saw great improvements on it? I want to follow a protocol, so I think it would me more complex than just buying a bottle of wine and taking aleatory doses.

I'm not sure on the dosages, I don't know if gbold has really ever specified and I wouldn't expect him to. Resveratrol + DHT has been the combo he's thrown around. So something like knotweed and r-andro cycled together might be worth trying for some people. I'm not sure though. I am really not an expert on PFS.

You could use the resveratrol example though, it acts as a ER agonist but it can increase estrogen signaling and resensitize it.

There is no resveratrol protocol. He has said estrogen + dht will fix you very quickly, but it likely won’t last once you come off. In terms of balancing you longer term, he has suggested taking it with Thorne extra or even with zinc + manganese, as you’re getting the needed minerals but also keeping estrogen signalling high for libido.

I’ve taken one or two standard resveratrol pills for the last few days/week and noticed the improvements very fast.

Removing free copper and iron in the brain and getting estrogen going again seems really key in curing pfs.

 

[Canari]

Just curious...how many mg of resveratrol per day are you taking? Are you taking DHT with it? Any cofactors, or are you still on your minerals/aspirin protocol?

I then stopped taking everything and started taking 10mg of manganese and 40mg of zinc and in a day or two I returned to my previous baseline. After 3 days I added resveratrol to the mix, the idea being I needed to increase my estrogen sensitivity so my body can use copper. The next day my labido jumped up maybe 5 to 10% and I had really good morning wood. Also around this time the dark circles under my eyes went away and so did the liver pressure.

My experience so far concreted the idea that I have issues with estrogen sensitivity. I began reading through gbolduev old posts to see if there was anything that could help. I found one of his protocols recommending RU followed by resveratrol and thorn extra which sounded pretty good to me because I know I respond good to both. Gbolduev also mentioned that resveratrol is a better version of CDnuts herbs and to cycle resveratrol. I am still a believer in CDnuts protocol and believe the herbs work on more levels than just increasing estrogen sensitivity.

If you are low in estrogen you are probably sensitive to it, meaning resveratrol will do nothing for you (it's a sensitizer, better for people with high estrogen once you come off). If you are low in estrogen, you need to figure out ways to stimulate production.

For guys with high prog and low estrogen, you want to shunt that prog into cortisol synthesis. So you fast for a long time, water or breuss is probably fine. It's that simple. The stress of fasting will balance prog and estrogen and increase cortisol production (while also causing cortisol sensitization). This will also raise NAD+ which will facilitate 3b-HSD reaction. You also can't be in alkalosis when you are fasting for a long time, it's pretty much impossible.

Still to early to say but I have been seeing little spurts of labido and generally feeling good while following zinc finger protocol. I have been taking 2mg of copper, 40mg zinc, 200mg of resveratrol, 10mg of manganese, 1 pill of thrones extra for b vitamins, magnesium, and I have been taking a 1/4 teaspoon of potassium chloride with whey protein twice a day.

Problem that I found with resveratrol is that it chelates bioavailable copper.

I thought excess copper intake resulted in elevated Estrogen and resveratrol should be used to bring Estrogen back down. Is that incorrect?

 

[Minime]

I have been taking Resveratrol for the past 6 days. Its from ResVitale. The bottle says each dosage is 700mg of a Resveratrol Polyphenol Complex [Wildcrafted Japanese Knotweed extract (polygonum cuspidatum) (root & rhizome), Organic French Whole Grape (vitis vinifera) (skin, seeds, fruit, stem, vine), Organic Muscadine (vitis rotundifolia) (seed & skin)] standardized to contain 250mg of trans-Resveratrol.

So I guess I’ve been taking 250mg of trans-Resveratrol each day.
I don’t think anyone has concluded on whether or not it should be cycled so I plan to go one week on, one week off, one week on, etc.

@gbolduev mentioned the ones with high Estrogen need to take care of prolactin however my prolactin is in range so I’m not sure what that means for me.

Also a concern is that it chelates bioavailable copper.

So far a lot of hair shedding coinciding with the resveratrol. Maybe I need to be taking cofactors with it to prevent the hair shedding(?)

 

[bruschi11]

@Minime I think this is a great idea for you with your estrogen insensitivity issue. I told someone on solvepfs about this as well. Definitely worth a shot.

 

[Area-1255]

The idea of water fasting and such to balance hormones is very interesting. Especially the cortisol feedback loop. Most people just think in terms of increasing HGH/IGF-1 and balancing blood sugar levels. When in truth, fasting does a lot more than that.

 

[tanedout]

I have been taking Resveratrol for the past 6 days. Its from ResVitale. The bottle says each dosage is 700mg of a Resveratrol Polyphenol Complex [Wildcrafted Japanese Knotweed extract (polygonum cuspidatum) (root & rhizome), Organic French Whole Grape (vitis vinifera) (skin, seeds, fruit, stem, vine), Organic Muscadine (vitis rotundifolia) (seed & skin)] standardized to contain 250mg of trans-Resveratrol.

So I guess I’ve been taking 250mg of trans-Resveratrol each day.
I don’t think anyone has concluded on whether or not it should be cycled so I plan to go one week on, one week off, one week on, etc.

@gbolduev mentioned the ones with high Estrogen need to take care of prolactin however my prolactin is in range so I’m not sure what that means for me.

Also a concern is that it chelates bioavailable copper.

So far a lot of hair shedding coinciding with the resveratrol. Maybe I need to be taking cofactors with it to prevent the hair shedding(?)

Grape seed extract (which contains resveratrol) is one of things that results in a brief return of sensitivity and libido for me, and it occurred when I was supplementing it, whereas a similar effect I got from tribulus was a bounce-back. Still sounds like a good idea to cycle

 

[Minime]

It just dawned on me that I had stopped taking my thyroid medication for a week or two and I started up again about the same time I started taking resveratrol. So perhaps my recent dramatic hair loss is due to the thyroid medication rather than the resveratrol. However, my thyroid medication has never caused dramatic hair loss in the past so I’m not sure what to conclude...

 

[bruschi11]

Lose the thyroid medication. Just go resveratrol.

 

[Minime]

Not sure that is an option for me. I have severe hoshimoto’s as my antibodies are extremely elevated.

 

[Minime]

Wow I lost a lot more hair over night. At this rate I will be bald within a couple weeks. The amount of hair I have lost in the past week is crazy. Anyone have any thoughts on why Thyroid meds or resveratrol would induce extreme shedding? And how to stop it?
@gbolduev
@mattyb
Others...anyone?

 

[HerrFisch]

Why did you stop your thyroid meds if you have hashimotos?

 

[Helen]

Just stop resveratrol. I dont get when people take stuff that is making them worse. Stop it and see if you do ok on thyroid. Alone, I have no idea why people would use resveratrol, As I mentioned it many times, it fixes nothing. It does not make you sensitive to estrogen. it makes you sensitive to estrogen while you takin it since it is estrogen. And with a thyroid diseases why would you take estrogen

Res can causes copper deficiency and lower your estrogen after you come off not while you are on it. since IT IS ESTROGEN.

Come off now and see where your baseline is


Hashimoto is an autoimmune disease, And supplementing thyroid in it is worthless in my opinion.

You need to concentrate on fixing the autoimmune problem

 

[Minime]

Thanks guys. I will stop the resveratrol and continue with Thyroid meds and see how that goes.
By the way I started taking resveratrol because I have really high estrogen per my labs (everything else was in range).

 

[Minime]

Why did you stop your thyroid meds if you have hashimotos?

I was preparing to send in hair for a hair analysis and thought it would be a good idea to come off meds for a few days before collecting hair samples. Probably not a good idea(?)