ZINC FINGER THEORY DISCUSSION for PFS - 2 cases

[Shadow]

@TubZy I think you should post your update. You are experienced in this. Otherwise pe



there is no tumor , bud LOL

I dont know what he wants to see, he just requested a tomography, and Im pretty sure it isnt a tumor lol

 

[Helen]

Conn's syndrome is what he is testing for. But in your blood it shows that is not that. No idea why he is testing for it.

 

[Helen]

It is histidine cysteine zinc balance. so some can probably have high histidine, low cysteines,some high cysteine low histidine. And zinc. We will figure out how to balance these. and eventually have clean protocols. now still experimenting,

 

[Aleksandr]

Oh my god i'm speaking to a hair test practitioner now and shes saying im a fast 1 not a slow 4.. WTF after 3 months of supping slow oxidiser stuff

 

[tanedout]

Oh my god i'm speaking to a hair test practitioner now and shes saying im a fast 1 not a slow 4.. WTF after 3 months of supping slow oxidiser stuff

How has she come to that conclusion, don't the results of your Trace Minerals hair analysis say what sort of oxidiser you are?

 

[wuf]

I dont know what he wants to see, he just requested a tomography, and Im pretty sure it isnt a tumor lol

in my first years of PFS syndrome I had aldosterone more than double range, for my doctor indicated tumor as well.. did the suggested tests and no tumor (I am still alive).
But if you feel to be more relaxed on testing, get a test.

 

[wuf]

It is histidine cysteine zinc balance. so some can probably have high histidine, low cysteines,some high cysteine low histidine. And zinc. We will figure out how to balance these. and eventually have clean protocols. now still experimenting,

As you know I still have PFS and DHEA crash, I won't jump on any protocol now, but.... Do you think this protocol is fine also for me, since you told me I am a different case (cause DHEA crash).
I think I will go for resveratron soon.
Let me know please, so I can plan my next steps.
Thank you man!

 

[Canari]

Oh my god i'm speaking to a hair test practitioner now and shes saying im a fast 1 not a slow 4.. WTF after 3 months of supping slow oxidiser stuff

At least you got it right when you did not want to fast! Please update in your log! Why? what is the difference? We talked before - I remember - about similarities between some slows and fasts...

 

[TubZy]

Also have you seen this? @gbolduev

It seems to have all the aminos in free form

https://www.amazon.com/gp/aw/d/B00R...fYZAL&ref=plSrch#immersive-view_1513345426156

 

[Helen]

Also have you seen this? @gbolduev

It seems to have all the aminos in free form

https://www.amazon.com/gp/aw/d/B00R...fYZAL&ref=plSrch#immersive-view_1513345426156

It is not as easy as supping just aminos.

 

[Helen]

Everyone should read this.

http://newtreatments.org/fromweb/sulfur.html

 

[TubZy]

It is not as easy as supping just aminos.

I know.. but all the aminos you listed in your original post are included there in good forms. So instead of buying 10 different individual supplements they are all there in proper form. Also, you could take more histidine or cysteine on top of that if needed. And of course with brewers yeast for minerals/B's and extra betaine hcl for enhaced absorption if needed.

 

[Sevens]

I can say something to my experience with this whole thing.
I dont have PFS but i think im stuck in a same way as those people, I’ve used Deca ( Nandrolone) for a long Time and now im off steroids for about 4 Month. I have done the Clomid Protocol from gbolduev with no results. I ordered some aminos after reading this whole discussion here and started to take Essenital Amino Acids , Aspartic Acid and Serine from Myprotein.com. For the first time after Those couple month i started to feel libido again. I’m Taking those things for 5 days now and really got the feeling my body moves forward.I have some spontaneous and strong erections and my Testicles are a little bit bigger finally. I take all the aminos with betain HCL.
I also use Selenium, B12 sublingual 2500 IU, 1 gr Folate, Niacin 250 Mcg, 3 mg Copper, and 25 mg Zink + Vit e 400 IU, Citrulin and Arginin 4 gr each.

The Essential Aminos ( 15 gr per Day) contain :
Leucine 5gr
Valine 2.2gr
Lysine 2.2gr
Phenylalanine 1.8gr
Threoine 1.5gr
Isoleucine 890mg
Hisditine 720mg
Methionine 500mg
Tryptophan 200mg

@gbolduev
Do you think its neccary to add L Tyrosine and Beta Alanine?

 

[mattyb]

Everyone should read this.

http://newtreatments.org/fromweb/sulfur.html

This is similar to what I was looking into when I was researching multiple sclerosis religiously. I believe improper sulfur metabolism and ultimately deficiency is causing problems. Some really old research I had found showed that people with MS produced misfolded proteins that lacked disulfide bridges necessary for tertiary structure. I don't think it is as simple as a deficiency, but that the deficiency is caused by something upstream - but despite that I think some supplementation can work. When you have a ton of ROS in your system it will lead to creation of sulfur radicals and therefore sulfur wasting.

I think Ebselen is a great candidate drug for this, since it mediates the formation of disulfide bridges and selenylsulfides. Ebselen just so happens to localize into the endoplasmic reticulum, which are rich in cysteine and where these disulfide bridges are formed. And it has a secondary function of accelerating thioredoxin/glutathione recycling, which is needed to maintain a high concentration of intracellular thiols (that will inevitably be oxidized and integrated into tertiary protein structure in the ER).

 

[tanedout]

This is similar to what I was looking into when I was researching multiple sclerosis religiously. I believe improper sulfur metabolism and ultimately deficiency is causing problems. Some really old research I had found showed that people with MS produced misfolded proteins that lacked disulfide bridges necessary for tertiary structure. I don't think it is as simple as a deficiency, but that the deficiency is caused by something upstream - but despite that I think some supplementation can work. When you have a ton of ROS in your system it will lead to creation of sulfur radicals and therefore sulfur wasting.

I think Ebselen is a great candidate drug for this, since it mediates the formation of disulfide bridges and selenylsulfides. Ebselen just so happens to localize into the endoplasmic reticulum, which are rich in cysteine and where these disulfide bridges are formed. And it has a secondary function of accelerating thioredoxin/glutathione recycling, which is needed to maintain a high concentration of intracellular thiols (that will inevitably be oxidized and integrated into tertiary protein structure in the ER).

Reminded me of this study, which looks specifically at SAMe and it's use as a therapy in mitigating the effects of retionic acid (i.e. isotretinion/accutane)

http://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=4063&context=etd

 

[Helen]

This is similar to what I was looking into when I was researching multiple sclerosis religiously. I believe improper sulfur metabolism and ultimately deficiency is causing problems. Some really old research I had found showed that people with MS produced misfolded proteins that lacked disulfide bridges necessary for tertiary structure. I don't think it is as simple as a deficiency, but that the deficiency is caused by something upstream - but despite that I think some supplementation can work. When you have a ton of ROS in your system it will lead to creation of sulfur radicals and therefore sulfur wasting.

I think Ebselen is a great candidate drug for this, since it mediates the formation of disulfide bridges and selenylsulfides. Ebselen just so happens to localize into the endoplasmic reticulum, which are rich in cysteine and where these disulfide bridges are formed. And it has a secondary function of accelerating thioredoxin/glutathione recycling, which is needed to maintain a high concentration of intracellular thiols (that will inevitably be oxidized and integrated into tertiary protein structure in the ER).

Cysteine levels are elevated in MS. So the deficiency in CDO seems to be the culpit. It has to do either with low histidine OR low iron delivery.

Also it could be from carnosinase deficiency, and you know what is needed for that? MANGANESE. Without manganese I think histidine levels will be low.

May be this is the culpit for MS and iron toxicity is the cause. In this case Chlorides and salt, will be really bad for people with MS. Since chloride is anti Manganese. I remember I had people allergic to sea water. It caused eczema which is histidine deficiency. After adding Manganese it was gone.


It would be interesting to see beta alanine and histidine urine levels in MS.


I guess another possibility would be manganese toxicity and iron deficiency. So I think it is histidine iron manganese balance which should be looked in for MS

https://link.springer.com/article/10.1385/BTER:93:1-3:1

 

[mattyb]

MS is multifactorial. Exposure to tons of different things can cause the problem. Where I live (central Canada) ionizing radiation is the primary cause because we live in a conduit line where ionizing radiation from solar activity is concentrated. The province I live in has the highest rates of MS per capita in the world.

But exposure to metals can cause it as well. There are many cases, it's important to figure out each person's MS on a case by case basis, and where they live can give us hints of what those causes may be.

 

[TubZy]

@TubZy I think you should post your update. You are experienced in this.



there is no tumor , bud LOL Tell him you dont have Conn's syndrome. Waste of money to test that,

I will post it tonight

 

[TubZy]

I can say something to my experience with this whole thing.
I dont have PFS but i think im stuck in a same way as those people, I’ve used Deca ( Nandrolone) for a long Time and now im off steroids for about 4 Month. I have done the Clomid Protocol from gbolduev with no results. I ordered some aminos after reading this whole discussion here and started to take Essenital Amino Acids , Aspartic Acid and Serine from Myprotein.com. For the first time after Those couple month i started to feel libido again. I’m Taking those things for 5 days now and really got the feeling my body moves forward.I have some spontaneous and strong erections and my Testicles are a little bit bigger finally. I take all the aminos with betain HCL.
I also use Selenium, B12 sublingual 2500 IU, 1 gr Folate, Niacin 250 Mcg, 3 mg Copper, and 25 mg Zink + Vit e 400 IU, Citrulin and Arginin 4 gr each.

The Essential Aminos ( 15 gr per Day) contain :
Leucine 5gr
Valine 2.2gr
Lysine 2.2gr
Phenylalanine 1.8gr
Threoine 1.5gr
Isoleucine 890mg
Hisditine 720mg
Methionine 500mg
Tryptophan 200mg

@gbolduev
Do you think its neccary to add L Tyrosine and Beta Alanine?

Thanks you mind also making a log too? You can copy/paste. Only reason I say it because your post will eventually get drowned out in this thread.

 

[Helen]

@mattyb

Just found some soviet research on radiation and what they used for Chernobyl.

Treatment; Histidine, tryptophan. vitamins B1, B6, Р, dibazol


Lol this is what I used against my cancer basically. I increased tryptophan levels by using IDO ihibitors. plus I was taking tons of histidine. and catalitic triad.

And the funny thing, that red light that they talk about it over at Ray Peat forum. Increased my tumors by 2-3 fold. It was crazy. I could not understand what was happening. May be it was causing even more depletion of tryptophan and histidine

By the way , there is a russian guy Bolotov, who cured hundreds of thousand people from cancer , and his main ingredient was tryptophan.