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I'm not entirely sure yet as just looking into this and only just found study linking accutane to 5HT1A, but from the research both accutane and SSRI's could lead to upregulation/increased activity of 5HT1A receptors, increased activity of 5HT1A receptors has been linked to reduced sexual...

Yes but for those 3-4 days, did you get normal libido/sexual functioning? Or are you just referring to what other people have said? Yes if correct, I believe you are right about the receptor/enzymes imbalance, if side effects completly resided for for some time (I've just never been aware this...

I think its possible that both PSSD and accutane sexual dysfunction, possibly PFS also involves an issue with dopamine receptor signalling. However the reasons for this dysfunction, probably differ.

Thats interesting. So do you have PSSD? Funnily enough, I haven't read too much into PSSD. Check this link out - Serotonin 5-HT(1)A Receptor and Male Sexual Function / Motivation - Brain Health Note this article - 5-HT1A receptor agonists prevent in rats the yawning and penile erections induced...

I was convinced this had something to do with accutane affecting androgen receptors. Which made sense in the light of its activation of FOXO transcription factors which negatively regulate/block androgen receptors. Given this, increasing accutane results in increased FOXO activity and decreased...

Hi bro, just interested what kind of TRT are you taking? is it testosterone based such as Testosterone Ethanate or DHT based steroid like Masteron? I'm interested as some people have reported benefits from TRT and others have reported no benefit. It's possible DHT based give sexual benefits but...

Did this help with libido?

What do you mean by extremely aroused dopaminergic system? is that when you've taken a dopamine agonist?

Hi there, I was just wondering. Were you suffering from sexual dysfunction (low libdo etc.) before taking finasteride? and did taking the finasteride improve your libido? or did you have a normal libido before taking finasteride?

This is a great idea. I think we need to collate all the info on symptoms, treatments etc. Would be very useful.

Thanks for the reply, that interesting. I'm interested as Isotretinoin/accutane has been shown to reduce IGF-1 which acts as a potent inducer of 5 alpha reductase activity. So I'm interested in whether there is any evidence that Isotretinoin/accutane directly inhibits 5 alpha reductase activity...

I am currently researching the causes of accutane induced sexual dysfunction. I have seen on many forums, people say that accutane/isotretinoin is a 5 alpha reductase inhibitor. However I am struggling to find research papers which support this claim. Could people please link any research...

I'm still researching the theory, reading/writing it up as speak. Will let you know sometime next week bro. Yes its strange, but may be related to your usage of DHT-related steroids versus my usage of straight testosterone. It's possible that both of our 5 alpha reductase activity is...

I understand man. Its tough to deal with, but you have to fight on. The anhedonia and depersonalisation is likely related to depression. I have used things which have helped me significantly with anhedonia and depression side effects but its slightly controversial to mention as they are illegal...

Maybe it was the oxandrolone that gave the slight libido increase. It would be interesting to see if there is a difference in mental effects of taking a steroid such as testosterone versus taking DHT derivatives. The effect of your cycle is similar to mine. Its unusual, as normally a cycle...

Thank you for keeping us updated bro.

I wanted to know, is it possible due to DHT activity in the brain. For somebody who has taken Accutane or Fin to have seemingly normal androgen activity in muscles. I.e. can gain muscle strength/growth yet gain non of the mental effects of testosterone such as increased aggression, increased...

#28 Have you ever had blood tests done? If so, did you ever get growth hormone, IGF-1 or IGFBP-3 tested? Have you experimented with exogenous testosterone supplements?

Yeah thats interesting. I only used testosterone ethanate, so its possible if accutane has permanently messed with my 5 alpha reductase activity, that I still had relatively low DHT whilst on cycle. Can you remember what doses you took? and how long it took for libido to increase? So what was...