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Is this guy from acne.org?? Does he have any reason to be lying? If not this sounds like amazing news!!

Hi Tubzy, ok thats great. Thanks for the info. Do we have any idea how many people have tried this protocol and found it reversed symptoms?

Thats great to hear bro. Did it help with sexual side effects? Also could you give me info on source of estrogen and DHT? like brands/products. I want to test but I don't know what to get. I have looked at DHT based steroids such as Masteron but confused how to raise/supplement estrogen?

Just out of interest, has anyone tried the DHT + estrogen route. I know its only a temporary fix but surely it would be very useful to know whether it actually works. As surely if people tried this route and it didn't work or do anything, then all the other protocols may need to be rethought...

yeah interestingly, I think there are links between dopamine release and steroids such as testosterone but sometimes the dopamine release only occurs if estrogen is present etc. so its possible that if our problems really are related to progesterone sensitivity, this may have altered our...

What do you mean by get clear? The thing I don't understand is, progesterone can't act as an antagonist because it is the real hormone and binds to progesterone receptors, activating them. So if accutane use increases progesterone. In response the cell will downregulate the progesterone...

OK thanks for the reply, you are a legend! Just out of interest I have found that both retinol and retinoic acid significantly increased the accumulation of progesterone in rats granulosa cells compared to controls (1). Retinoic acid/all trans-RA (ATRA) increased progesterone production in...

Slightly confused here. Gbols states that progestins bind to and block the activity of the progesterone receptor. wikipedia states that progestins act as agonists, activating the progesterone receptor? Has he got this mixed up? Given this, excessive use of a progestin would result in...

Could anyone clarify the link between progesterone, progestins etc. in relation to accutane. Gbols theories make complete sense in relation to PFS but I'm confused about how it links to accutane? Would be greatly appreciated!!!

I'm really starting to think that dopamine underlies much of the sexual side effects we feel. Particularly with Accutane induced sexual dysfunction. Also possible with Fin as its been shown to damage the nucleus accumbens I think its possible that our dopamine receptors have been down regulated...

Could you do a water fast with coconut water then? And so even though you never had sexual side effects you still think you gained some sexual benefit from protocol??

Has anyone with accutane induced sexual side effects, ever used L-dopa? or a dopamine agonist. Or dopamine antagonist?

Ok so its possible fasting could help the libido sides? When you say water fast, are you literally eating nothing except water? What source of progesterone were you using?

No I haven't test progesterone, prolactin DHT, estrogen yet but I intend to. I've noticed that my head hair is thinning and I\m worried I will under go premature balding now. I did notice shedding whilst on accutane but never thought much of it. I have had no hair loss on legs, back, torso...

Yeah bro, I got blood tests for GH, IGF1 etc. expensive as hell but it all contribute to the cause I guess. Will post them soon. But all you need to know is, our problem is not IGF-1, IGFBP-3, GH, thyroid hormones, testosterone. At least not for me. THe only thing that came in low for me, for...

Anyone tried reservatrol? I know gbol says its only a temporary fix for PFS but right now, I'd be amazed if any supplement can give me a libido, even if it disappears without the supplement. Would really bring my hopes up of finding a way to treat this.

Ah, I can't believe I missed this study. I've literally been writing a whole article about possible treatment for sexual sides using growth hormone to increase IGF-1 -> increase PI3K/AKT signalling and thus remove FOXOS. Have you ever tried a 5HT1A agonist?

Hi, thats really interesting man. I've never really had a temporary recovery like this. Temporary recovery gives a sign of hope, that the damage is reversible. And you're sure that none of these one off recoveries could have been placebo or down to you being a good mood? Like was the difference...

Are there any post accutane sufferers currently experimenting with any of the protocols on this forum such as Gbols protocols? Have they noticed any improvement or found any protocols to be ineffective (not worth trying)? Would be useful to know, I'm looking to jump on a protocol or get some...