if you are not making adrenaline and noradrenaline, then your Beta -2 receptors are not activated, this causes histamine release from the mast cells.
if you are not methylating you could be down on everything serotonin, dopamine , noradrenaline, adrenaline.
Right! this may very well be a Methylation issue. If I take a b complex, I might feel good for about a day then it goes down hill from there.
And that brings me back to the blocked detox pathways, I feel good at first but then my body gets poisoned by whatever I am taking because it can't detox.
I need to go read all your old stuff about liver and glutathione and also Dr. Chris Shade's material. He talks a lot about how NRF-2 Up-regulation is a big factor here.
I think I need to fix GI problems and then Liver problems, and THEN try to improve Methylation